558 Result(s)
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Article
Open AccessSqualene epoxidase promotes the chemoresistance of colorectal cancer via (S)-2,3-epoxysqualene-activated NF-κB
While de novo cholesterol biosynthesis plays a crucial role in chemotherapy resistance of colorectal cancer (CRC), the underlying molecular mechanism remains poorly understood.
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Article
The activation of P38MAPK Signaling Pathway Impedes the Delivery of the Cx43 to the Intercalated Discs During Cardiac Ischemia–Reperfusion Injury
Ischemic heart disease is caused by coronary artery occlusion. Despite the increasing number and success of interventions for restoring coronary artery perfusion, myocardial ischemia–reperfusion (I/R) injury r...
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Article
Strategy of endophytic bacterial communities in alfalfa roots for enhancing plant resilience to saline–alkali stress and its application
Soil salinization is an abiotic stress factor that can harm plant growth. Root endophytic bacteria may be associated with the resilience of plants to saline–alkaline stress. This study investigated the diversi...
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Article
Red Fluorescent Molecule with Aggregation-Induced Emission Based on Dehydroabietic Acid Diarylamine for Bioimaging
In this paper, molecules with AIE red light properties were designed by coupling dehydroabietic acid diarylamine and 2,3-diphenylfumaronitrile, which were designated 2DTPA-CN and 2TPA-CN. The emission waveleng...
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Article
Open AccessEvaluation of the consistency of the MRI- based AI segmentation cartilage model using the natural tibial plateau cartilage
The study aims to evaluate the accuracy of an MRI-based artificial intelligence (AI) segmentation cartilage model by comparing it to the natural tibial plateau cartilage.
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Article
Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization
The obesity epidemic continues to worsen worldwide, driving metabolic and chronic inflammatory diseases. Thiazolidinediones, such as rosiglitazone (Rosi), are PPARγ agonists that promote ‘M2-like’ adipose tiss...
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Article
Rolling V-groove microstructures on glass using a modified PDMS mold
Unlike polymers, glass is prone to fracturing under localized stress during roll embossing. Molds traditionally used for glass embossing are rigid and unsuitable for roll embossing. In this investigation, we u...
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Article
Open AccessLow pressure reversibly driving colossal barocaloric effect in two-dimensional vdW alkylammonium halides
Plastic crystals as barocaloric materials exhibit the large entropy change rivalling freon, however, the limited pressure-sensitivity and large hysteresis of phase transition hinder the colossal barocaloric ef...
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Article
Open AccessAssociation of emotional and behavioral problems with the development of the substantia nigra, subthalamic nucleus, and red nucleus volumes and asymmetries from childhood to adolescence: A longitudinal cohort study
The substantia nigra (SN), subthalamic nucleus (STN), and red nucleus (RN) have been widely studied as important biomarkers of degenerative diseases. However, how they develop in childhood and adolescence and ...
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Article
Open AccessImaging the state-to-state charge-transfer dynamics between the spin-orbit excited Ar+(2P1/2) ion and N2
Ar++N2 → Ar+N2+ has served as a paradigm for charge-transfer dynamics studies during the last several decades. Despite significant experimental and theoretical efforts on this model system, state-resolved experim...
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Article
Polymer coated γ-aminopropyltriethoxysilane-modified α-alumina non-spherical nanocomposite abrasives and their chemical mechanical polishing behavior on glass-ceramic substrate
This study aimed to overcome limitations associated with the use of alumina nanoparticles in the semiconductor manufacturing industry, including high hardness, inadequate dispersion, and substandard post-polis...
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Article
Open AccessStructural connectome architecture shapes the maturation of cortical morphology from childhood to adolescence
Cortical thinning is an important hallmark of the maturation of brain morphology during childhood and adolescence. However, the connectome-based wiring mechanism that underlies cortical maturation remains uncl...
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Chapter and Conference Paper
Sentiment Analysis of Teaching Evaluation Based on Complex Semantic Analysis
In the era of digital education, student evaluations of teachers constitute a crucial component of digital education. They serve as a driving force for promoting teaching reforms and are the fundamental basis ...
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Chapter and Conference Paper
A Novel Approximation Algorithm for Max-Covering Circle Problem
We study the efficient approximation algorithm for max-covering circle problem. Given a set of weighted points in the plane and a circle with specified size, max-covering circle problem is to find the proper p...
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Article
Open AccessIdentification of constrained sequence elements across 239 primate genomes
Noncoding DNA is central to our understanding of human gene regulation and complex diseases1,2, and measuring the evolutionary sequence constraint can establish the functional relevance of putative regulatory ele...
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Article
A comparative evaluation of mechanically reinforced and heat-resistant organic powder/polyurethane elastomer hybrid composites
Polyurethane elastomers are widely utilized in various engineering applications due to their favorable properties. However, their high surface energy and internal heat generation limit their potential use unde...
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Chapter and Conference Paper
Diversity and Freshness-Aware Regret Minimizing Set Queries
Multi-criteria decision-making often involves selecting a small representative set from a database. A recently proposed method is the regret minimization set (RMS) queries. It aims to rectify the shortcomings ...
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Article
Effects of CuO mass concentrations on water-based CuO nanofluid heat pipe for thermal energy extraction: inhibition of coal spontaneous combustion
To inhibit coal spontaneous combustion (CSC) effectively, the heat pipe (HP) technology has been employed for extracting thermal energy. Nanofluids are a new type of working fluid with special properties that ...
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Article
Open AccessExploring Gender Differences in Computational Thinking Learning in a VR Classroom: Develo** Machine Learning Models Using Eye-Tracking Data and Explaining the Models
Understanding existing gender differences in the development of computational thinking skills is increasingly important for gaining valuable insights into bridging the gender gap. However, there are few studie...
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Article
Open AccessRapid surveillance of New York City healthcare center egress behaviors during the 2020 COVID-19 lockdown
This rapid response surveillance project was funded by the National Science Foundation (NSF) to collect “perishable” data on egress behaviors and neighborhood conditions surrounding healthcare centers (HCCs) i...
