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Chromosome Bandings and Recognition
Chromosome banding can be defined as the lengthwise variation in staining properties along a chromosome stained with a dye. Chromosome banding became...
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The Importance of Monitoring Non-clonal Chromosome Aberrations (NCCAs) in Cancer Research
Cytogenetic analysis has traditionally focused on the clonal chromosome aberrations, or CCAs, and considered the large number of diverse non-clonal...
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Single-Cell MTT: A Simple and Sensitive Assay for Determining the Viability and Metabolic Activity of Polyploid Giant Cancer Cells (PGCCs)
Solid tumors and tumor-derived cell lines commonly contain highly enlarged (giant) cancer cells that enter a state of transient dormancy (active...
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Quantitative FISHing: Implications for Chromosomal Analysis
Quantifying signals substantially increases the efficiency of fluorescence in situ hybridization (FISH). Quantitative FISH analysis or QFISHing may...
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Generation of Polyploid Giant Cancer Cells (PGCCs) from Hey Ovarian Cancer Cells and Analysis of Embryonic Properties
Polyploid giant cancer cells (PGCCs) play a fundamental role in tumor initiation, dormancy, drug resistance, and metastasis, although the detailed...
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Multitarget Fluorescence In Situ Hybridization Diagnostic Applications in Tumors
Multitarget fluorescence in situ hybridization (mFISH) is a technique that allows the detection of multiple target sequences on the same sample using...
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A Paradoxical Role for Somatic Chromosomal Mosaicism and Chromosome Instability in Cancer: Theoretical and Technological Aspects
Somatic chromosomal mosaicism, chromosome instability, and cancer are intimately linked together. Addressing the role of somatic genome variations...
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Distribution of Small RNAs Along Transposable Elements in Vitis vinifera During Somatic Embryogenesis
Metaviridae is a family of reverse-transcribing viruses, closely related to retroviruses; they exist within their host’s DNA as transposable...
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Enrichment, Sequencing, and Identification of DNA Bacteriophages from Fecal Samples
Research on individual viruses and phages, as well as viral populations (viromes), is greatly expanding. Phages and viromes are increasingly...
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Viromes of Plants Determined by High-Throughput Sequencing of Virus-Derived siRNAs
Plants growing in open airfields can be infected by several viruses even as a multiple infection. Virus infection in crops can lead to a serious...
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Metagenomic Analyses of Viruses in the Orchid Mycorrhizal Interaction Using Improved Assemble Tools
In nature, mycorrhizal association with soil-borne fungi is indispensable for orchid species. Compatible mycorrhizal fungi form endo-mycorrhizal...
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From Metagenomics to Ecogenomics: NGS-Based Approaches for Discovery of New Circular DNA Single-Stranded Viral Species
Viruses comprise the most abundant genetic material in the biosphere; however, global viral genomic population (virome) has been largely...
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Identification of DNA Viruses in Ancient DNA from Herbarium Samples
Herbaria encompass millions of plant specimens, mostly collected in the nineteenth and twentieth centuries that can represent a key resource for...
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Application of Nanopore-Based Sequencing to Identify Virus Infections in Woody Plants
Plant viruses threaten the yield and quality of crops. Efficient and affordable pathogen diagnosis is crucial to regulate the trade of plant...
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Exploring the Archaeal Virosphere by Metagenomics
During the past decade, environmental research has demonstrated that archaea are abundant and widespread in nature and play important ecological...
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Liquid Biopsy in Coronary Heart Disease
Cardiovascular disease (CVD) remains the major cause of morbidity and mortality globally. Accumulating evidence indicates that coronary heart disease...
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The Value of Cell-Free Circulating DNA Profiling in Patients with Skin Diseases
Liquid biopsy, also known as fluid biopsy or fluid-phase biopsy, is the sampling and analysis of the blood, cerebrospinal fluid, saliva, pleural...
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The Implication of Liquid Biopsy in the Non-small Cell Lung Cancer: Potential and Expectation
Nowadays, lung cancer has remained the most lethal cancer, despite great advances in diagnosis and treatment. However, a large proportion of patients...
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Liquid Biopsy in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the most deadly neoplasms with a poor prognosis. Due to the significant tumor heterogeneity of HCC,...