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BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells
Interleukin-17 (IL-17)-producing helper T (T H 17) cells are heterogenous and consist of nonpathogenic T H 17 (npT H 17) cells that contribute to tissue...
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MHC class II proteins mediate sialic acid independent entry of human and avian H2N2 influenza A viruses
Influenza A viruses (IAV) pose substantial burden on human and animal health. Avian, swine and human IAV bind sialic acid on host glycans as...
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Intracellular domain of epithelial cell adhesion molecule induces Wnt receptor transcription to promote colorectal cancer progression
BackgroundEpithelial cell adhesion molecule (EpCAM) has been widely studied as a tumor antigen due to its expression in varieties of solid tumors....
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HMGB1 as an extracellular pro-inflammatory cytokine: Implications for drug-induced organic damage
Drug-induced organic damage encompasses various intricate mechanisms, wherein HMGB1, a non-histone chromosome-binding protein, assumes a significant...
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Genomic representativeness and chimerism in large collections of SAGs and MAGs of marine prokaryoplankton
BackgroundSingle amplified genomes (SAGs) and metagenome-assembled genomes (MAGs) are the predominant sources of information about the coding...
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Association of ambient temperature on acute ischemic stroke in Yancheng, China
BackgroundAcute ischemic stroke (AIS) is a major global public health issue. There is limited research on the relationship between ambient...
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Isotoosendanin inhibits triple-negative breast cancer metastasis by reducing mitochondrial fission and lamellipodia formation regulated by the Smad2/3-GOT2-MYH9 signaling axis
Triple-negative breast cancer (TNBC) is incurable and prone to widespread metastasis. Therefore, identification of key targets for TNBC progression...
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Antibody targeting of anaerobic bacteria warms cold tumors and improves the abscopal effect of radiotherapy
BackgroundThe combination of immune checkpoint inhibitors with radiotherapy can enhance the immunomodulation by RT and reduce the growth of distant...
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Endoplasmic reticulum stress promotes hepatocellular carcinoma by modulating immunity: a study based on artificial neural networks and single-cell sequencing
IntroductionHepatocellular carcinoma (HCC) is characterized by the complex pathogenesis, limited therapeutic methods, and poor prognosis. Endoplasmic...
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An Indigenous-informed sco** review study methodology: advancing the science of sco** reviews
BackgroundHistorically, Indigenous voices have been silent in health research, reflective of colonial academic institutions that privilege Western...
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Finite element simulation of treatment with locking plate for distal fibula fractures
An improved Finite Element Model(FEM) is applied to compare the biomechanical stability of plates with three different options in the treatment of...
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DNA methylation, but not microRNA expression, is affected by in vitro THC exposure in bovine granulosa cells
BackgroundA global increase in cannabis use has led to questions about its effects on fertility. The rise in consumption amongst women of...
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From traditional to transactional: exploration of khat use in Ethiopia through an interpretative phenomenological analysis
Khat, a naturally growing stimulant, has seen a significant increase in both consumption and cultivation in eastern Ethiopia. This reliance on khat...
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Predicting pharmaceutical prices. Advances based on purchase-level data and machine learning
BackgroundIncreased costs in the health sector have put considerable strain on the public budgets allocated to pharmaceutical purchases. Faced with...
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Detection and characterization of H5N1 HPAIV in environmental samples from a dairy farm
The recent expansion of HPAIV H5N1 infections in terrestrial mammals in the Americas, most recently including the outbreak in dairy cattle,...
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Peptides for microbe-induced cancers: latest therapeutic strategies and their advanced technologies
Cancer is a significant global health concern associated with multiple distinct factors, including microbial and viral infections. Numerous studies...
