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Increasing Diversity, Equity, Inclusion, and Accessibility in Rare Disease Clinical Trials
Diversity, equity, inclusion, and accessibility (DEIA) are foundational principles for clinical trials and medical research. In rare diseases...
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Methylprednisolone Modulates the Tfr/Tfh ratio in EAE-Induced Neuroinflammation through the PI3K/AKT/FoxO1 and PI3K/AKT/mTOR Signalling Pathways
Methylprednisolone (MP) is a potent glucocorticoid that can effectively inhibit immune system inflammation and brain tissue damage in Multiple...
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Protective effects of ginsenosides on ulcerative colitis: a meta-analysis and systematic review to reveal the mechanisms of action
BackgroundUlcerative colitis (UC) is a chronic inflammatory disease of the colon. Ginsenoside may be an ideal agent for UC treatment. However, its...
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Current standards and the future role of hadrontherapy in the treatment of central nervous system tumors
IntroductionRadiation therapy is vital for treating central nervous system cancers (CNS), but traditional methods have limitations, especially in...
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An Intrusion Detection System on The Internet of Things Using Deep Learning and Multi-objective Enhanced Gorilla Troops Optimizer
In recent years, developed Intrusion Detection Systems (IDSs) perform a vital function in improving security and anomaly detection. The effectiveness...
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Androgen transition and management of hereditary angioedema long-term prophylaxis in real life: a single-center case series
BackgroundHereditary angioedema (HAE) is a rare and potentially life-threatening disease that manifests clinically as recurrent episodes of swelling...
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Measures of overnight oxygen saturation to characterize sleep apnea severity and predict postoperative respiratory depression
BackgroundSleep apnea syndrome, characterized by recurrent cessation (apnea) or reduction (hypopnea) of breathing during sleep, is a major risk...
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Enantiomeric resolution of three profen drugs using direct thin-layer chromatographic method
This study presents the enantiomeric resolution of three profen drugs, viz ., flurbiprofen (FLB), fenoprofen, and zaltoprofen by employing...
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Impacts of X-linked Retinitis Pigmentosa and Patient Pathways in European Countries: Results from the Cross-sectional EXPLORE XLRP-1 Physician Survey
IntroductionX-linked retinitis pigmentosa (XLRP) is a rare, incurable, vision-threatening, genetic disease. In this study, we aimed to reveal the...
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Increased Risk of Severe Cardiovascular Events Following Exacerbations of Chronic Obstructive Pulmonary Disease: Results of the EXACOS-CV Study in Japan
IntroductionSevere exacerbations of chronic obstructive pulmonary disease (COPD) are known to increase the risk of cardiovascular events. However,...
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Usability of the SB11 Pre-filled Syringe (PFS) in Patients with Retinal Diseases
IntroductionSB11 (Byooviz™; Samsung Bioepis Co., Ltd.) is a ranibizumab (Lucentis ® ; Genentech, Inc.) biosimilar targeting vascular endothelial...
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Dosimetric characteristics of self-expandable metallic and plastic stents for transpapillary biliary decompression in external beam radiotherapy
There is little evidence regarding radiation dose perturbation caused by the self-expandable metallic stents (SEMSs) used for transpapillary biliary...
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ENTPD1 (CD39) and NT5E (CD73) expression in human medulloblastoma: an in silico analysis
Medulloblastoma is the most common malignant tumor in the pediatric population. Its classification has incorporated key molecular variations...
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Electrically actuated peristaltic transport of viscoelastic fluid: a theoretical analysis
In this article, we discuss the bioinspired peristaltic pum** mechanism of an elastic non-Newtonian fluid whose rheology is characterized by the...
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Hinesol attenuates DSS-induced ulcerative colitis through the suppression of Src-mediated NF-κB and chemokine signaling pathway
As a common inflammatory bowel disease, ulcerative colitis (UC) is featured with inflammation, oxidative damage, and the impairment of intestinal...
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Electrochemical Immunoassay Using Diffusion Layer Dispersion Effect of Electrodes
Diffusion layer dispersed electrodes were presented for application in electrochemical immunoassays. The diffusion layer refers to the region on the...
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Extracellular Microvesicles vs. Mitochondria: Competing for the Top Spot in Cardiovascular Regenerative Medicine
Regenerative medicine aims to restore, replace, and regenerate human cells, tissues, and organs. Despite significant advancements, many cell therapy...
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Pharmacokinetics of piperaquine and its association with intermittent malaria preventive therapy outcomes during pregnancy
BackgroundDihydroartemisinin-piperaquine (DHP) recently showed superior effectiveness over sulfadoxine-pyrimethamine for malaria intermittent...
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Magnetoactive, Kirigami-Inspired Hammocks to Probe Lung Epithelial Cell Function
IntroductionMechanical forces provide critical biological signals to cells. Within the distal lung, tensile forces act across the basement membrane...
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Gait Characteristics and Adaptation Strategies of Ants with Missing Legs
This paper systematically studies the movement behavior changes of Camponotus japonicus under one or two leg injuries. Firstly, a linear motion...
