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Comparing the Proteomic Profiles of Extracellular Vesicles Isolated using Different Methods from Long-term Stored Plasma Samples
BackgroundThe lack of standardized protocols for isolating extracellular vesicles (EVs), especially from biobank-stored blood plasma, translates to...
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Exploring the Significance of Somaclonal Variations in Horticultural Crops
Genetic and epigenetic variations produced via cell and tissue culture open up new sources of variability intra-species which can be used to improve...
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Apolipoprotein E in Alzheimer’s disease trajectories and the next-generation clinical care pathway
Alzheimer’s disease (AD) is a complex, progressive primary neurodegenerative disease. Since pivotal genetic studies in 1993, the ε4 allele of the...
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Reward prediction error neurons implement an efficient code for reward
We use efficient coding principles borrowed from sensory neuroscience to derive the optimal neural population to encode a reward distribution. We...
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High-throughput volumetric map** of synaptic transmission
Volumetric imaging of synaptic transmission in vivo requires high spatial and high temporal resolution. Sha** the wavefront of two-photon...
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DNA simulation benchmarks revealed with the accumulation of high-resolution structures
DNA carries more than the list of biochemical instructions that drive the basic functions of living systems. The sequence of base pairs includes a...
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Novel fabrication of macromolecular multi-functional hydrogel encapsulated with HUCB-derived mesenchymal stem cells to effective regeneration of cardiac repair after acute myocardial infarction
Acute myocardial infarction (AMI) has been treated via injectable hydrogels and biomaterial patches invented using tissue engineering advancements...
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Permittivity tensor imaging: modular label-free imaging of 3D dry mass and 3D orientation at high resolution
The dry mass and the orientation of biomolecules can be imaged without a label by measuring their permittivity tensor (PT), which describes how...
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Quantifying cell-state densities in single-cell phenotypic landscapes using Mellon
Cell-state density characterizes the distribution of cells along phenotypic landscapes and is crucial for unraveling the mechanisms that drive...
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Pupal Exuviae of Culex Pipiens L. (Diptera: Culicidae) Can be Utilised as a Non-Invasive Method of Biotype Differentiation
BackgroundCulex pipiens L. is a principal vector of zoonotic arboviruses in Europe, acting in both an amplification role in enzootic transmission...
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Multi-Segment Foot Kinematics during Gait in Adults with Asymptomatic and Symptomatic Flatfoot
PurposeTo investigate the differences in foot kinematics during gait between adults with asymptomatic and symptomatic flatfoot.
Methods ...
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Electro-elution-based purification of covalent DNA–protein cross-links
Covalent DNA–protein cross-links (DPCs) are pervasive DNA lesions that challenge genome stability and can be induced by metabolic or chemotherapeutic...
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Computational Analysis of Albaflavenone Interaction with SlMAPK1 for Drought Resistance in Tomato
As global agricultural challenges intensify, particularly drought stress, the exploration of innovative strategies for crop resilience has become...
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Haplotype Inference Using Long-Read Nanopore Sequencing: Application to GSTA1 Promoter
Recovering true haplotypes can have important clinical consequences. The laboratory process is difficult and is, therefore, most often done through...
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Assessing RNA atomistic force fields via energy landscape explorations in implicit solvent
Predicting the structure and dynamics of RNA molecules still proves challenging because of the relative scarcity of experimental RNA structures on...
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High-throughput single-cell transcriptomics of bacteria using combinatorial barcoding
Microbial split-pool ligation transcriptomics (microSPLiT) is a high-throughput single-cell RNA sequencing method for bacteria. With four...
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The HADDOCK2.4 web server for integrative modeling of biomolecular complexes
Interactions between macromolecules, such as proteins and nucleic acids, are essential for cellular functions. Experimental methods can fail to...
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Quantifying DNA replication speeds in single cells by scEdU-seq
In a human cell, thousands of replication forks simultaneously coordinate duplication of the entire genome. The rate at which this process occurs...
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An Automatic Approach of Video-Based Landmark Detection and Movement Analysis for Assessing Symptoms of Bradykinesia in Parkinson’s Disease
PurposeParkinson’s disease (PD) is a complex neurodegenerative disorder characterized by diverse symptoms. Diagnosis relies on established criteria...
