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Magnesium malate-modified calcium phosphate bone cement promotes the repair of vertebral bone defects in minipigs via regulating CGRP
Active artificial bone substitutes are crucial in bone repair and reconstruction. Calcium phosphate bone cement (CPC) is known for its...
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Efficient molecular conformation generation with quantum-inspired algorithm
ContextConformation generation, also known as molecular unfolding (MU), is a crucial step in structure-based drug design, remaining a challenging...
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Structural and electronic properties of clathrate-like hydride: MH6 and MH9 (M = Sc, Y, La)
ContextThe addition of central metal atoms to hydrogen clathrate structures is thought to provide a certain amount of “internal chemical pressure” to...
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Diagnosis and treatment status of inoperable locally advanced breast cancer and the application value of inorganic nanomaterials
Locally advanced breast cancer (LABC) is a heterogeneous group of breast cancer that accounts for 10–30% of breast cancer cases. Despite the ongoing...
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Microneedle delivery system with rapid dissolution and sustained release of bleomycin for the treatment of hemangiomas
Hemangioma of infancy is the most common vascular tumor during infancy and childhood. Despite the proven efficacy of propranolol treatment, certain...
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M6A demethylase FTO-stabilized exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell damage via the miR-642a-5p/FOXO1 axis
BackgroundPremature ovarian insufficiency (POI) is an important cause of female infertility and seriously impacts the physical and psychological...
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Microfluidics-enabled mesenchymal stem cell derived Neuron like cell membrane coated nanoparticles inhibit inflammation and apoptosis for Parkinson’s Disease
Parkinson’s disease (PD) is the second largest group of neurodegenerative diseases, and its existing drug treatments are not satisfactory. Natural...
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Breaking barriers: bacterial-microalgae symbiotic systems as a probiotic delivery system
The gut microbiota is one of the essential contributors of the pathogenesis and progress of inflammatory bowel disease (IBD). Compared with...
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Potentiating dual-directional immunometabolic regulation with nanomedicine to enhance anti-tumor immunotherapy following incomplete photothermal ablation
Photothermal therapy (PTT) is a promising cancer treatment method due to its ability to induce tumor-specific T cell responses and enhance...
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Computational explorations about the solvent-polarity-associated excited state proton transfer behaviors for the novel F-BSD compound
ContextInspired by the excellent potential application prospects from the precisely controlled attributes displayed by...
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Lumacaftor as a potential repurposed drug in targeting breast cancer stem cells: insights from in silico study
ContextBreast cancer stem cells (BCSCs) are a small subset of cells within breast tumors with characteristics similar to normal stem cells. Despite...
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Mechanistic and kinetic insights of the formation of allene and propyne from the C3H3 reaction with water
ContextAllene (H 2 C = C = CH 2 ) and propyne (CH 3 -C≡CH) are important compounds in the combustion chemistry. They can be created from the reaction of...
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Nanoscale insights into hematology: super-resolved imaging on blood cell structure, function, and pathology
Fluorescence nanoscopy, also known as super-resolution microscopy, has transcended the conventional resolution barriers and enabled visualization of...
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Macrophage biomimetic nanoparticle-targeted functional extracellular vesicle micro-RNAs revealed via multiomics analysis alleviate sepsis-induced acute lung injury
Patients who suffer from sepsis typically experience acute lung injury (ALI). Extracellular vesicles (EVs) contain miRNAs, which are potentially...
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Cold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy
Recently, environmental temperature has been shown to regulate bone homeostasis. However, the mechanisms by which cold exposure affects bone mass...
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Cargo-eliminated osteosarcoma-derived small extracellular vesicles mediating competitive cellular uptake for inhibiting pulmonary metastasis of osteosarcoma
Osteosarcoma (OS) derived small extracellular vesicles (OS-sEVs) have been shown to induce the formation of cancer-associated fibroblasts (CAFs),...
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Harnessing synergistic effects in GQD@Pt(II) nanocomposites for enhanced photovoltaic performance: a computational study
ContextThe development of efficient solar energy conversion technologies is crucial for addressing global energy challenges and reducing reliance on...
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Triangular graphene nanosheets, structures with extraordinary bending behavior
ContextSometimes, manipulating the geometry or creating a defect can help the engineering of the nanostructured properties, such as increasing the...
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Thermal decomposition mechanism of HMX/HTPB hybrid explosives studied by reactive molecular dynamics
ContextThe thermal decomposition process of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine/hydroxyl-terminated polybutadiene (HMX/HTPB) hybrid...
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Sonodynamic and sonomechanical effect on cellular stemness and extracellular physicochemical environment to potentiate chemotherapy
BackgroundHypoxia-activated prodrug (HAP) is a promising candidate for highly tumor-specific chemotherapy. However, the oxygenation heterogeneity and...
