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Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development
The immunological mechanisms underlying chronic colitis are poorly understood. T follicular helper (T FH ) cells are critical in hel** B cells during...
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Effects of acetate-producing Blautia wexlerae on oxidative stress and NLRP3 inflammasome in obesity-associated male infertility
Background: Obesity-associated male infertility is a common complication of obesity and has been increasing in prevalence. Blautia wexlerae has...
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Novel insights into the glucose metabolic alterations of freshwater snails: a pathway to molluscicide innovation and snail control strategies
As ecosystem disruptors and intermediate hosts for various parasites, freshwater snails have significant socioeconomic impacts on human health,...
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BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells
Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in pancreatic cancer (PC) progression. However, driver...
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Associations between immune cell traits and autoimmune thyroid diseases: a bidirectional two-sample mendelian randomization study
Autoimmune thyroid diseases (AITDs), mainly including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), are common autoimmune disorders...
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Systemic treatment options for non-small cell lung cancer after failure of previous immune checkpoint inhibitors: a bayesian network meta-analysis based on randomized controlled trials
BackgroundAlthough immune checkpoint inhibitors (ICIs) have brought survival benefits to non-small cell lung cancer (NSCLC), disease progression...
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Immune-mediated inflammatory diseases and periodontal disease: a bidirectional two-sample mendelian randomization study
BackgroundPrevious observational studies have shown a bidirectional association between immune-mediated inflammatory disorders (IMID) and periodontal...
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Integrated One-Health approach for prevention and control of Opisthorchis viverrini infection in rural Thailand: a 3-year study
Opisthorchis viverrini infection is a pressing health issue in rural Southeast Asia and is associated with the risk of cholangiocarcinoma. Despite...
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Plasma H3Cit-DNA Discriminates Between Cancer and Inflammation in a Cohort of Patients with Unspecific Cancer Symptoms
Cancer detection is challenging, especially in patients with unspecific cancer symptoms. Biomarkers could identify patients at high risk of cancer....
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Transcriptomics-based liquid biopsy panel for early non-invasive identification of peritoneal recurrence and micrometastasis in locally advanced gastric cancer
BackgroundThis study aimed to develop a novel six-gene expression biomarker panel to enhance the early detection and risk stratification of...
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Oncoprotein LAMTOR5-mediated CHOP silence via DNA hypermethylation and miR-182/miR-769 in promotion of liver cancer growth
C/EBP homologous protein (CHOP) triggers the death of multiple cancers via endoplasmic reticulum (ER) stress. However, the function and regulatory...
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Lipid droplet accumulation mediates macrophage survival and Treg recruitment via the CCL20/CCR6 axis in human hepatocellular carcinoma
Metabolic changes play a crucial role in determining the status and function of macrophages, but how lipid reprogramming in macrophages contributes...
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The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to severe COVID-19 in the Iranian population
BackgroundVariations in the innate and adaptive immune response systems are linked to variations in the severity of COVID-19. Natural killer cell...
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Induced expression of rabies glycoprotein in the dorsal hippocampus enhances hippocampal dependent memory in a rat model of Alzheimer’s disease
The Rabies virus is a neurotropic virus that manipulates the natural cell death processes of its host to ensure its own survival and replication....
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Limited HIV-associated neuropathologies and lack of immune activation in sub-saharan African individuals with late-stage subtype C HIV-1 infection
Although previous studies have suggested that subtype B HIV-1 proviruses in the brain are associated with physiological changes and immune activation...
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Exploring CCR5 + T regulatory cell subset dysfunction in type 1 diabetes patients: implications for immune regulation
T regulatory lymphocytes (Treg) expressing CCR5 exhibit strong suppression activity in various autoimmune disorders. However, there remains a lack of...
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4-1BB-encoding CAR causes cell death via sequestration of the ubiquitin-modifying enzyme A20
CD28 and 4-1BB costimulatory endodomains included in chimeric antigen receptor (CAR) molecules play a critical role in promoting sustained antitumor...
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Evaluation of the effects of the Zika Virus-Immunoglobulin G+ complex on murine microglial cells
After the Zika virus (ZIKV) epidemic in Brazil, ZIKV infections were linked to damage to the central nervous system (CNS) and congenital anomalies....
