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  2. BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells

    Interleukin-17 (IL-17)-producing helper T (T H 17) cells are heterogenous and consist of nonpathogenic T H 17 (npT H 17) cells that contribute to tissue...

    Pratiksha I. Thakore, Alexandra Schnell, ... Aviv Regev in Nature Immunology
    Article 15 July 2024

  3. Advancements in pathogen immunity and signaling

    Mads Gyrd-Hansen, Anna Kajaste-Rudnitski, ... Matteo Iannacone in Nature Immunology
    Article 15 July 2024

  4. A life-course multisectoral approach to precision health in LMICs

    Stefan Swartling Peterson, Olive Kobusingye, ... Peter Waiswa in Nature Medicine
    Article 15 July 2024

  5. Intracellular domain of epithelial cell adhesion molecule induces Wnt receptor transcription to promote colorectal cancer progression

    Background

    Epithelial cell adhesion molecule (EpCAM) has been widely studied as a tumor antigen due to its expression in varieties of solid tumors....

    Sushree Shankar Panda, Chi-Chiu Lee, ... Han-Chung Wu in Journal of Biomedical Science
    Article Open access 15 July 2024

  7. Peptides for microbe-induced cancers: latest therapeutic strategies and their advanced technologies

    Cancer is a significant global health concern associated with multiple distinct factors, including microbial and viral infections. Numerous studies...

    Ziqi Lin, Yehuda G. Assaraf, Hang Fai Kwok in Cancer and Metastasis Reviews
    Article 15 July 2024

  8. Isotoosendanin inhibits triple-negative breast cancer metastasis by reducing mitochondrial fission and lamellipodia formation regulated by the Smad2/3-GOT2-MYH9 signaling axis

    Triple-negative breast cancer (TNBC) is incurable and prone to widespread metastasis. Therefore, identification of key targets for TNBC progression...

    **g-nan Zhang, Ze Zhang, ... Li-li Ji in Acta Pharmacologica Sinica
    Article 15 July 2024

  9. Antibody targeting of anaerobic bacteria warms cold tumors and improves the abscopal effect of radiotherapy

    Background

    The combination of immune checkpoint inhibitors with radiotherapy can enhance the immunomodulation by RT and reduce the growth of distant...

    WeiZhou Wang, YunXue Zheng, ... **gBo Wu in Journal of Translational Medicine
    Article Open access 15 July 2024

  10. Endoplasmic reticulum stress promotes hepatocellular carcinoma by modulating immunity: a study based on artificial neural networks and single-cell sequencing

    Introduction

    Hepatocellular carcinoma (HCC) is characterized by the complex pathogenesis, limited therapeutic methods, and poor prognosis. Endoplasmic...

    Zhaorui Cheng, Shuangmei Li, ... Tong Wang in Journal of Translational Medicine
    Article Open access 15 July 2024

  12. Finite element simulation of treatment with locking plate for distal fibula fractures

    An improved Finite Element Model(FEM) is applied to compare the biomechanical stability of plates with three different options in the treatment of...

    Yafeng Li, Zichun Zou, ... **g Zhang in Physical and Engineering Sciences in Medicine
    Article 15 July 2024

  13. DBScope as a versatile computational toolbox for the visualization and analysis of sensing data from deep brain stimulation

    Different neurostimulators for deep brain stimulation (DBS) come already with the ability to chronically sense local field potentials during...

    Andreia M. Oliveira, Eduardo Carvalho, ... Paulo Aguiar in npj Parkinson's Disease
    Article Open access 15 July 2024

  14. In Memoriam: Alberto Piazza (1941–2024)

    Giuseppe Matullo, Antonio Amoroso in European Journal of Human Genetics
    Article 15 July 2024

  15. A dual-targeting approach with anti-IL10R CAR-T cells engineered to release anti-CD33 bispecific antibody in enhancing killing effect on acute myeloid leukemia cells

    Background

    Immunotherapies, including chimeric antigen receptor (CAR) T cells and bispecific antibodies (BsAbs), encounter several challenges in the...

    Zhifeng Yan, Runxia Gu, ... Jianxiang Wang in Cellular Oncology
    Article 15 July 2024

  16. Circadian rhythm disruption upregulating Per1 in mandibular condylar chondrocytes mediating temporomandibular joint osteoarthritis via GSK3β/β-CATENIN pathway

    Background

    Temporomandibular joint osteoarthritis (TMJOA) has a high incidence rate, but its pathogenesis remains unclear. Circadian rhythm is an...

    Jiaming Wei, Yuxuan Wang, ... Zheng Chen in Journal of Translational Medicine
    Article Open access 15 July 2024

  19. Early depletion of gut microbiota shape oligodendrocyte response after traumatic brain injury

    White matter injury (WMI) is thought to be a major contributor to long-term cognitive dysfunctions after traumatic brain injury (TBI). This damage...

    Kirill Shumilov, Allen Ni, ... Stuart H. Friess in Journal of Neuroinflammation
    Article Open access 15 July 2024

  20. Synthesis and Neurobehavioral Evaluation of a Potent Multitargeted Inhibitor for the Treatment of Alzheimer’s Disease

    Alzheimer’s disease (AD) poses a significant health challenge worldwide, affecting millions of individuals, and projected to increase further as the...

    Mohd Shahnawaz Khan, Zuber Khan, ... Shams Tabrez in Molecular Neurobiology
    Article 15 July 2024
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