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Enhanced deep leaning model for detection and grading of lumbar disc herniation from MRI
Lumbar disc herniation is one of the most prevalent orthopedic issues in clinical practice. The lumbar spine is a crucial joint for movement and...
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Tear Fluid as a Matrix for Biomonitoring Environmental and Chemical Exposures
PurposeExposures to hazardous chemicals have been linked to many detrimental health effects and it is therefore critical to have effective...
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Carvacrol prevents D-( +)-galactose-induced aging-associated erectile dysfunction by improving endothelial dysfunction and oxidative stress in rats
Aging is one of the risk factors involved in the development of erectile dysfunction (ED). Growing evidence suggests that oxidative stress is the...
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Reinforcing effects of fentanyl analogs found in illicit drug markets
RationaleThe potent synthetic opioid fentanyl, and its analogs, continue to drive opioid-related overdoses. Although the pharmacology of fentanyl is...
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Development of an HPLC method using relative molar sensitivity for the measurement of blood concentrations of nine pharmaceutical compounds
We developed a reliable high-performance liquid chromatographic analysis method using a relative molar sensitivity (RMS) technique that does not...
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Likelihood comparisons in bounded outcome score analysis must be internally consistent
Clinical trial endpoints are often bounded outcome scores (BOS), which are variables having restricted values within finite intervals. Common...
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Clinical significance of TROAP in endometrial cancer and the antiproliferative and proapoptotic effects of TROAP knockdown in endometrial cancer cells: integrated utilization of bioinformatic analysis and in vitro test verification
Trophinin-associated protein (TROAP), a cytoplasmic protein essential for spindle assembly and centrosome integrity during mitosis, has been reported...
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Unraveling psilocybin’s therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression
RationaleOur study aimed to unravel the unknown mechanisms behind the exceptional efficacy of Psilocybin (PSI) in treating treatment-resistant...
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Impact of CYP2D6*2, CYP2D6*35, rs5758550, and related haplotypes on risperidone clearance in vivo
PurposeThe CYP2D6 gene exhibits significant polymorphism, contributing to variability in responses to drugs metabolized by CYP2D6. While CYP2D6*2 ...
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Synthesis, structure-activity relationship and evaluation of antifungal activity of tryptanthrin derivatives against drug-resistant Candida albicans
With the increasing of Candida albicans infections year by year, and the widespread use of azole drugs, especially fluconazole has led to the...
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Fisetin ameliorates polycystic ovary syndrome in rats via a mechanistic modulation of AMP-activated protein kinase and SIRT1 molecular pathway
Fisetin , a polyphenolic flavonoid, exhibits numerous pharmacological activities against metabolic syndromes. The present research aims to explore the...
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DNN-BP: a novel framework for cuffless blood pressure measurement from optimal PPG features using deep learning model
AbstractContinuous blood pressure (BP) provides essential information for monitoring one’s health condition. However, BP is currently monitored using...
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Sodium Houttuyfonate Ameliorates DSS-induced Colitis Aggravated by Candida albicans through Dectin-1/NF-κB/miR-32-5p/NFKBIZ Axis Based on Intestinal microRNA Profiling
Our previous research indicated that Sodium houttuyfonate (SH) can effectively ameliorate dextran sulfate sodium (DSS)-induced colitis exacerbated by C...
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Real-world safety and effectiveness of pirfenidone and nintedanib in the treatment of idiopathic pulmonary fibrosis: a systematic review and meta-analysis
Background and objectiveMultiple randomized controlled studies have shown that pirfenidone and nintedanib are effective and safe for treating...
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Chemical composition and studying the possible neuroprotective effect of iridoids-rich fraction from Pentas lanceolata leaves using rotenone model of Parkinson’s disease in mice
Parkinsonism is an age-related neurodegenerative illness that affects motor coordination leading to loss of dopaminergic neurons. Many medications...
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Kinin B1 receptor and TLR4 interaction in inflammatory response
ObjectiveWe aimed to broaden our understanding of a potential interaction between B1R and TLR4, considering earlier studies suggesting that...
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The 60-year evolution of lipid nanoparticles for nucleic acid delivery
Delivery of genetic information to the interior of target cells in vivo has been a major challenge facing gene therapies. This barrier is now being...
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Cerebral White Matter Alterations Associated With Oligodendrocyte Vulnerability in Organic Acidurias: Insights in Glutaric Aciduria Type I
The white matter is an important constituent of the central nervous system, containing axons, oligodendrocytes, and its progenitor cells, astrocytes,...
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Demystifying the potential of lipid-based nanocarriers in targeting brain malignancies
Drug targeting for brain malignancies is restricted due to the presence of the blood–brain barrier (BBB) and blood–brain tumor barrier (BBTB), which...
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Preparation of poly(vinyl alcohol) nanofibers containing disulfiram-copper complex by electrospinning: a potential delivery system against melanoma
BackgroundMelanoma poses a significant threat to human health, making the development of a safe and effective treatment a crucial challenge....
