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Complete genome sequence of a novel amalgavirus in sponge gourd, Luffa cylindrica
A novel monopartite dsRNA virus, tentatively named “sponge gourd amalgavirus 1” (SGAV1), was discovered by high-throughput sequencing in sponge gourd...
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Metabolomic and lipidomic profiling of the spinal cord in type 2 diabetes mellitus rats with painful neuropathy
In this paper we investigated lipid and metabolite changes in diabetic neuropathy, using untargeted lipidomics and metabolomics analyses of the...
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Pharmacokinetics and Histotoxic Profile of a Novel Azithromycin-Loaded Lipid-Based Nanoformulation
Azithromycin traditional formulations possesses poor oral bioavailability which necessitates development of new formulation with enhanced...
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Lateral root enriched Massilia associated with plant flowering in maize
BackgroundBeneficial associations between plants and soil microorganisms are critical for crop fitness and resilience. However, it remains obscure...
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Distribution Clearance: Significance and Underlying Mechanisms
PurposeEvaluation of distribution kinetics is a neglected aspect of pharmacokinetics. This study examines the utility of the model-independent...
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Formulation and Antimycotic Evaluation of Colloidal Itraconazole-Loaded Metered Dose Sprays for Treating Superficial Mycoses
Commercial topical formulations containing itraconazole (poorly water soluble), for mycotic infections, have poor penetration to infection sites...
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Development of a Novel Soft Tissue Measurement Device for Individualized Finite Element Modeling in Custom-Fit CPAP Mask Evaluation
PurposeIndividual facial soft tissue properties are necessary for creating individualized finite element (FE) models to evaluate medical devices such...
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Design, Characterization and Biopharmaceutical Applications of Novel Green Boron-Carbon Quantum Dots for Quantification of Apalutamide; Greenness Evaluations
The diagnosis of prostate cancer has been evolving in the current decade, with expected mortality rates of 499,000 death by the year 2030....
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Fitness costs of Tn1546-type transposons harboring the vanA operon by plasmid type and structural diversity in Enterococcus faecium
BackgroundThis study analyzed the genetic traits and fitness costs of vancomycin-resistant Enterococcus faecium (VREfm) blood isolates carrying Tn 1546...
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Update on the Regulation and Maintenance of Epstein-Barr Virus Latency
Purpose of ReviewAs the first identified human oncogenic virus, Epstein-Barr virus (EBV) is widely circulating in humans. EBV presents mainly in...
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Drug-induced ER stress leads to induction of programmed cell death pathways of the malaria parasite
The rapid emergence of drug resistance against the mainstream antimalarial drugs has increased the need for development of novel drugs. Recent...
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Synthesis and anti-leishmanial activities of uniflorol analogues
Chromanones are a subset of the benzopyran family, and display diverse biological activities, both as natural products and synthetic derivatives....
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Controlling Alzheimer’s disease by deep brain stimulation based on a data-driven cortical network model
This work aims to explore the control effect of DBS on Alzheimer's disease (AD) from a neurocomputational perspective. Firstly, a data-driven...
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A novel betapartitivirus isolated from Cordyceps militaris, an edible-medicinal mushroom
In this study, we identified a novel partitivirus, named "Cordyceps militaris partitivirus 1" (CmPV1), in Cordyceps militaris strain RCEF7506. The...
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A quantitative modeling framework to understand the physiology of the hypothalamic-pituitary-adrenal axis and interaction with cortisol replacement therapy
Congenital adrenal hyperplasia (CAH) is characterized by impaired adrenal cortisol production. Hydrocortisone (synthetic cortisol) is the...
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Evaluation of the Transfemoral Bone–Implant Interface Properties Using Vibration Analysis
Evaluating the bone–implant interface (BII) properties of osseointegrated transfemoral (TFA) implants is important for early failure detection and...
