9,440 Result(s)
within
Jian-**ao Liu
English
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Article
Design and optimization of carbon materials as anodes for advanced potassium-ion storage
With the swift advancement of renewable energy and escalating demands for energy storage, potassium-ion batteries (PIBs) are increasingly recognized as a potent energy storage technology. Various carbon anode ...
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Article
Clinical features, disease progression, and nuclear imaging in ATXN2-related parkinsonism in a longitudinal cohort
Spinocerebellar ataxia 2 (SCA2) with a low range of CAG repeat expansion of ATXN2 gene can present with predominant or isolated parkinsonism that closely resembles Parkinson’s disease (PD). This study is aimed at...
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Article
Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses
Major depressive disorder, a prevalent and severe psychiatric condition, necessitates development of new and fast-acting antidepressants. Genetic suppression of astrocytic inwardly rectifying potassium channel...
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Open AccessUnderstanding the genetic complexity of puberty timing across the allele frequency spectrum
Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, th...
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Synthesis and pharmacological evaluation of polyamine-diarylidenyl piperidone derivatives as potent antitumor agents
Two polyamine-diarylidenyl piperidone (DAP) derivatives, dimer polyamine-H-4073 and tetrameric polyamine-H-4073, were designed and synthesized as antitumor agents by coupling the bifluoro-substituted DAP STAT3...
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Article
A deep learning model for translating CT to ventilation imaging: analysis of accuracy and impact on functional avoidance radiotherapy planning
Radiotherapy planning incorporating functional lung images has the potential to reduce pulmonary toxicity. Free-breathing 4DCT-derived ventilation image (CTVI) may help quantify lung function. This study intro...
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Study on the Characteristics of Slurry Support Efficiency on Excavation Face Induced by Shield Cutterhead Cutting in Sand Stratum
During the slurry shield machine tunnelling in sand stratum with strong permeability, it can be challenging to achieve the filter cake formation on the excavation face in time. The continuous damage of shield ...
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Single-cell transcriptomics across 2,534 microbial species reveals functional heterogeneity in the rumen microbiome
Deciphering the activity of individual microbes within complex communities and environments remains a challenge. Here we describe the development of microbiome single-cell transcriptomics using droplet-based s...
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Perpendicularly assembled oriented electrospinning nanofibers based piezoresistive pressure sensor with wide measurement range
With the rapid development of wearable electronics, flexible pressure sensors have attracted wide attention in human-computer interaction and intelligent machines. However, it is a challenge to achieve a senso...
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Article
A data-driven approach for predicting the fatigue life and failure mode of self-piercing rivet joints
In lightweight automotive vehicles, the application of self-piercing rivet (SPR) joints is becoming increasingly widespread. Considering the importance of automotive service performance, the fatigue performanc...
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Article
Observation of robust anisotropy in WS2/BP heterostructures
Two-dimensional (2D) anisotropic materials have garnered significant attention in the realm of anisotropic optoelectronic devices due to their remarkable electrical, optical, thermal, and mechanical properties...
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Observation on the Analgesic Effect of Different Doses of a Combination of Esketamine and Dexmedetomidine Administered for Percutaneous Endoscopic Transforaminal Discectomy: A Randomized, Double-Blind Controlled Trial
Percutaneous endoscopic transforaminal discectomy (PETD) is an effective method for treating lumbar disc herniation, and is typically performed under local anesthesia. However, inadequate analgesia during the ...
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Article
The marine-derived compound TAG alleviates Parkinson’s disease by restoring RUBCN-mediated lipid metabolism homeostasis
Parkinson’s disease (PD) is the second most common neurodegenerative disease, and its prevalence is increasing. Currently, no effective therapies for PD exist. Marine-derived natural compounds are considered i...
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Article
Recurrent neural network robust curvature tracking control of tendon-driven continuum manipulators with simultaneous joint stiffness regulation
Continuum manipulators, despite their prominent flexibility and compliance, possess relatively low inherent stiffness and weak load capacity. Realizing simultaneous curvature tracking control and joint stiffne...
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Article
Hemorrhagic Shock and Resuscitation Causes Excessive Dopaminergic Signaling in the mPFC and Cognitive Dysfunction
Peri-operative hemorrhagic shock and resuscitation (HSR), a severe traumatic stress, is closely associated with post-operative anxiety, depression, and cognitive dysfunction, subsequently causing a serious bur...
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Article
Clinical translation of a novel FAPI dimer [68Ga]Ga-LNC1013
Fibroblast activation protein (FAP) has emerged as a highly promising target for cancer diagnostic imaging and targeted radionuclide therapy. To exploit the therapeutic potential of suitably radiolabeled FAP i...
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Article
An Experimental Study on Fracturing Response and Slurry Flow of High-Pressure Grouting in Fractured Rock
Grouting has been commonly used for structure controlling in mining engineering. To investigate the mechanism of fracturing grouting, an experiment was conducted under constant flowing conditions. Through the ...
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Article
Microstructures and mechanical properties of laser-directed energy deposited CrCoNi medium-entropy alloy
The distinctive intrinsic heat treatment (IHT) originating from cyclic reheating in the laser-directed energy deposition (LDED) has attracted growing attention in recent years. In this investigation, simulatio...
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Article
Open AccessSystematic assessment of long-read RNA-seq methods for transcript identification and quantification
The Long-read RNA-Seq Genome Annotation Assessment Project Consortium was formed to evaluate the effectiveness of long-read approaches for transcriptome analysis. Using different protocols and sequencing platf...
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Article
Imbalanced instance selection based on Laplacian matrix decomposition with weighted k-nearest-neighbor graph
Data are an essential component for building machine learning models. Linearly separable high-quality data are conducive to building efficient classification models. However, the collected dataset is not of hi...
