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Article
Open AccessLinking alterations in estrogen receptor expression to memory deficits and depressive behavior in an ovariectomy mouse model
The high risk of neurological disorders in postmenopausal women is an emerging medical issue. Based on the hypothesis of altered estrogen receptors (ERα and β) after the decline of estrogen production, we inve...
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Article
Open AccessHeart-brain axis: low blood pressure during off-pump CABG surgery is associated with postoperative heart failure
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Article
Open AccessConcurrent spontaneous coronary dissection and reversible cerebral vasoconstriction syndrome during postnatal care
Pregnancy-associated spontaneous coronary artery dissection (SCAD) and reversible cerebral vasoconstriction syndrome (RCVS) are rare conditions that may occur during pregnancy and the postpartum period. The co...
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Article
Open AccessLactiplantibacillus plantarum K8 lysates regulate hypoxia-induced gene expression
Hypoxic responses have been implicated in critical pathologies, including inflammation, immunity, and tumorigenesis. Recently, efforts to identify effective natural remedies and health supplements are increasi...
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Article
Open AccessLeaf traits of prickly ash and its correlation with ecological and geographical factors of origin
The morphological, physiological, and biochemical characteristics of leaves result from the long-term adaptation of plants to their environment and are closely related to plant growth and development. In this ...
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Article
Open AccessCancer cell-specific and pro-apoptotic SMAC peptide-doxorubicin conjugated prodrug encapsulated aposomes for synergistic cancer immunotherapy
Immunogenic cell death (ICD) is a crucial approach to turn immunosuppressive tumor microenvironment (ITM) into immune-responsive milieu and improve the response rate of immune checkpoint blockade (ICB) therapy...
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Article
Open AccessFloat-stacked graphene–PMMA laminate
Semi-infinite single-atom-thick graphene is an ideal reinforcing material that can simultaneously improve the mechanical, electrical, and thermal properties of matrix. Here, we present a float-stacking strateg...
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Article
Open AccessAssociation between brain amyloid deposition and longitudinal changes of white matter hyperintensities
Growing evidence suggests that not only cerebrovascular disease but also Alzheimer’s disease (AD) pathological process itself cause cerebral white matter degeneration, resulting in white matter hyperintensitie...
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Article
Open AccessNationwide incidence of congenital and infantile cataract requiring surgery in Korea
Congenital and infantile (CI) cataract is one of the most important and preventable cause of blindness in children, but the incidence has not been studied in Korea. We collected data from the national claims d...
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Article
Open AccessDynamic chloride ion adsorption on single iridium atom boosts seawater oxidation catalysis
Seawater electrolysis offers a renewable, scalable, and economic means for green hydrogen production. However, anode corrosion by Cl- pose great challenges for its commercialization. Herein, different from conven...
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Article
Open AccessThe Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress
Mitophagy induction upon mitochondrial stress is critical for maintaining mitochondrial homeostasis and cellular function. Here, we found that Mst1/2 (Stk3/4), key regulators of the Hippo pathway, are required...
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Article
Open AccessGenetic drivers of heterogeneity in type 2 diabetes pathophysiology
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic c...
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Article
Open AccessPrmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy
Protein arginine methyltransferases (PRMTs) modulate diverse cellular processes, including stress responses. The present study explored the role of Prmt7 in protecting against menopause-associated cardiomyopat...
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Article
Open AccessSex-dependent different clinicopathological characterization of Epstein–Barr virus-associated gastric carcinoma: a large-scale study
Epstein–Barr virus (EBV)-associated gastric cancer (EBVaGC) has been reported to account for approximately 5–16% of all GCs with good prognosis compared to EBV-negative GC. We evaluated the clinicopathological...
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Open AccessAlcohol and the risk of all-cause death, atrial fibrillation, ventricular arrhythmia, and sudden cardiac arrest
The risk of having atrial fibrillation (AF) is associated with alcohol intake. However, it is not clear whether sudden cardiac arrest (SCA) and ventricular arrhythmia (VA) including ventricular tachycardia, fl...
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Open AccessLow pressure reversibly driving colossal barocaloric effect in two-dimensional vdW alkylammonium halides
Plastic crystals as barocaloric materials exhibit the large entropy change rivalling freon, however, the limited pressure-sensitivity and large hysteresis of phase transition hinder the colossal barocaloric ef...
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Open AccessReading of small bowel capsule endoscopy after frame reduction using an artificial intelligence algorithm
Poorly visualized images that appear during small bowel capsule endoscopy (SBCE) can confuse the interpretation of small bowel lesions and increase the physician’s workload. Using a validated artificial intell...
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Article
Open AccessCT whole lung radiomic nomogram: a potential biomarker for lung function evaluation and identification of COPD
Computed tomography (CT) plays a great role in characterizing and quantifying changes in lung structure and function of chronic obstructive pulmonary disease (COPD). This study aimed to explore the performance...
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Article
Open AccessMental imagery scaffolding: The effects of detail richness and text load on geography learning
The growing importance of 3D animations in current teaching approaches becomes increasingly apparent, offering an effective way to visualize complex spatial concepts and processes in geography learning through...
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Open AccessComparative estimation of the effects of antihypertensive medications on schizophrenia occurrence: a multinational observational cohort study
The association between antihypertensive medication and schizophrenia has received increasing attention; however, evidence of the impact of antihypertensive medication on subsequent schizophrenia based on larg...
