104 Result(s)
within
Internal Medicine
**u-**u Zhang
Chapter
Medicine & Public Health
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Chapter
Antidepressant Drugs and Phosphodiesterases
This section aims to introduce the antidepressants and phosphodiesterases (PDEs) from four aspects. First, the general principle and background information of antidepressants are introduced, and the relationsh...
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Leukocytes in the Vaso-Occlusive Process
Sickle cell disease (SCD) results from a single mutation in the β-globin gene, leading to clinical manifestations that extend far beyond the mutated hemoglobin in red blood cells (RBCs). SCD is associated with a ...
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B Cells in Cancer Immunology: For or Against Cancer Growth?
The role played by B cells in cancer immunology is complex and somewhat controversial. Depending upon their state of activation, B cells have had divergent roles in T cell differentiation and effector function...
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T Cell Immunotherapy: From Synthetic Biology to Clinical Practice
T lymphocytes have the ability to recognize, eliminate, and control cancer by means of their cytolytic potential, production of soluble mediators, and their ability to alter the tumor microenvironment. Polyclo...
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Lipoprotein(a)
Lipoprotein(a), Lp(a), a complex between a low-density lipoprotein (LDL)-like lipid moiety containing one copy of apolipoprotein (apo) B, and apo(a), a plasminogen-derived, carbohydrate-rich, hydrophilic prote...
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B Cell Regulation of Antitumor Response
While the role of CD4+ T cells, cytolytic T cells, natural killer cells, and Th1 response in antitumor immunity has been appreciated for decades, a variety of human and murine tumors are heavily infiltrated with ...
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Esophageal Cancer: Neoadjuvant and Adjuvant Therapy
The incidence of esophageal cancer has increased more than 15 % in the past 20 years. It ranks fifth in mortality rate among cancers. Squamous cell carcinoma (SCC) and adenocarcinoma (AC) account for the major...
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The Liver and Immune Tolerance
As the largest solid organ in the body, the liver plays a critical role in metabolism and detoxification. Recently, emerging evidence suggests that the liver is an immunological organ with unique properties of...
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The Development of Psychosomatic Medicine in China, Vietnam, and Laos—The ASIA-LINK Program
With the programme “ASIA-Link” the European Community supported the development and implementation of a curriculum for postgraduate psychosomatic training for medical doctors in China, Vietnam and Laos. Curren...
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Transplantation: Kidney, Kidney–Pancreas Transplant
With in-depth understanding of transplant immunology, more sensitive assays have been developed for immunological risk assessment, crossmatch, and detection of donor-specific antibodies. The discovery of poten...
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Somatoform Disorders
Patients present multiple somatic symptoms and demand for a medical extermination despite negative organic findings (dysfunctional illness behaviour). The doctor–patient relationship is often difficult. Basic ...
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Biofortified Rice to Fight Folate Deficiency
Folates are water-soluble tripartite B-vitamins (B9), which are important cofactors in C1 metabolism, where they act as one-carbon donors and acceptors [1–4]. They play an important role in DNA biosynthesis, m...
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Cardiac KATP Channels in Health and Diseases
Adenosine triphosphate (ATP)-sensitive K+ (KATP) channels were discovered in the heart almost 30 years ago. They are present in multiple tissues and link membrane excitability to the metabolic state of the cell. ...
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Flavonoids of Herba Epimedii and Bone Metabolism in Experimental Ovarian Deficiency
Key Points
Flavonoids of Herba Epimedii could preserve bone health in OVX rodents, including bone histomorphology, micro-structure and bo...
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Accidental Arterial Puncture
Accidental arterial puncture is a rare complication that may occur during central venous catheter insertion. Arterial injury may be a potentially lethal problem of serious bleeding or large hematoma. The autho...
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Thrombosis
Catheter-related thrombosis is one of the late complications of totally implantable venous access port. Until now, few studies have introduced the practice of totally implantable venous access port in the clin...
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Obstructive Sleep Apnea: Diagnosis with Polysomnography and Portable Monitors
Definition of Obstructive Sleep Apnea (OSA): OSA is the leading cause of referral to sleep laboratories worldwide, accounting for at least 75–80% of diagnoses [1, 2]. In the last few decades, there have been c...
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The Mechanisms Underlying the Effects of C-Peptide on Type 1 Diabetic Neuropathy
Diabetic polyneuropathy (DPN) is the most common chronic complication of diabetes occurring in approximately 60% of diabetic patients [1–3]. It affects somato-sensory, nociceptive and autonomic peripheral ner...
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Mitochondrial Dysfunction in Neurodegenerative Disease: Protein Aggregation, Autophagy, and Oxidative Stress
Mitochondrial dysfunction is frequently associated with neurodegenerative diseases and is thought to be a major contributor to the pathophysiology of Parkinson’s, Alzheimer’s, Huntington’s, and stroke. The mec...
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C-Peptide and Type 1 Diabetic Encephalopathy
Diabetic encephalopathies are recently recognized complications affecting both type 1 and type 2 diabetic patients [1, 2]. With the increasing incidences of both types of diabetes, the central nervous system (...
