5,263 Result(s)
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Zhen-** Zhang
English
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Article
Open AccessNicotinate-curcumin improves NASH by inhibiting the AKR1B10/ACCα-mediated triglyceride synthesis
Nonalcoholic steatohepatitis (NASH) is a prevalent chronic liver condition. However, the potential therapeutic benefits and underlying mechanism of nicotinate-curcumin (NC) in the treatment of NASH remain unce...
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Open AccessDevelopment of a Pt(II) compound based on indocyanine green@human serum albumin nanoparticles: integrating phototherapy, chemotherapy and immunotherapy to overcome tumor cisplatin resistance
Cisplatin resistance is the main cause for the failure of cancer therapy. To solve the problem, we proposed to develop a novel human serum albumin (HSA) nanoplatform to integrate chemotherapy, photothermal the...
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Ensemble successor representations for task generalization in offline-to-online reinforcement learning
In reinforcement learning (RL), training a policy from scratch with online experiences can be inefficient because of the difficulties in exploration. Recently, offline RL provides a promising solution by givin...
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Two new aromatic tenvermectins from mutant Streptomyces avermitilis HU02-06
Two new aromatic tenvermectins (TVMs), 13-oleandrosyl-oleandrosyloxy ST906 (1) and aromatic TVM B (2), were isolated from the fermentation broth of Streptomyces avermitilis HU02-06. Their structures were establis...
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Predictive models for functional cure in patients with CHB receiving PEG-IFN therapy based on HBsAg quantification through meta-analysis
The efficacy of achieving HBsAg clearance through pegylated interferon (PEG-IFNα) therapy in patients with chronic hepatitis B (CHB) remains uncertain, especially regarding the probability of achieving functio...
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Open AccessIdentification of bladder cancer subtypes and predictive signature for prognosis, immune features, and immunotherapy based on immune checkpoint genes
Immunotherapy based on immune checkpoint genes (ICGs) has recently made significant progress in the treatment of bladder cancer patients, but many patients still cannot benefit from it. In the present study, w...
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SimAC: simulating agile collaboration to generate acceptance criteria in user story elaboration
In agile requirements engineering, Generating Acceptance Criteria (GAC) to elaborate user stories plays a pivotal role in the sprint planning phase, which provides a reference for delivering functional solutio...
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Open AccessMechanisms underlying neutrophils adhesion to triple-negative breast cancer cells via CD11b-ICAM1 in promoting breast cancer progression
Triple-negative breast cancer (TNBC) is recognized as the most aggressive and immunologically infiltrated subtype of breast cancer. A high circulating neutrophil-to-lymphocyte ratio (NLR) is strongly linked to...
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Effect of microalloying on wettability and interface characteristics of Zr-based bulk metallic glasses with W substrate
The infiltration casting method is widely employed for the preparation of ex-situ composite materials. However, the production of composite materials using this method must necessitates a comprehensive underst...
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Open AccessComparison of tacrolimus with or without prednisone therapy in primary membranous nephropathy: a retrospective clinical study
Previous studies showed tacrolimus monotherapy and dual therapy with tacrolimus and prednisone as effective treatment modalities in managing membranous nephropathy. However, few studies have compared these the...
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Application of optimized random forest regressors in predicting the maximum principal stress of aseismic tunnel lining
Using flexible dam** technology to improve tunnel lining structure is an emerging method to resist earthquake disasters, and several methods have been explored to predict mechanical response of tunnel lining...
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Open AccessNovel radiopaque ethanol injection: physicochemical properties, animal experiments, and clinical application in vascular malformations
Despite the efficacy of absolute ethanol (EtOH), its radiolucency introduces several risks in interventional therapy for treating vascular malformations. This study aims to develop a novel radiopaque ethanol i...
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One-neutron strip** process in the 209Bi(6Li, 5Li)210Bi* reaction reaction
One-neutron strip** process between \(^{6}\) 6 ...
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Open AccessTMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling
Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find that TMC6, a membrane protein of unknown function, is highly ...
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Microwave excited hyperthermy and catalysis of heterostructured Au/Cu–BTA for effective bacteria killing by accelerating charge separation
Deep tissue infections caused by pathogenic bacteria seriously threat the lives of patients. In this study, a smart heterostructured Au/Cu–BTA (BTA = 1,2,4,5-benzenetetramine) with microwave (MW) response is s...
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The role of soil microorganisms and physicochemical properties in determining the germinate of invasive Solidago canadensis L.
Several studies have shown that soil microorganisms and physicochemical properties are crucial for the successful colonisation of invasive plants. However, most researchers have focused merely on the impacts o...
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Open AccessCustomizable and stable multilocus chromosomal integration: a novel glucose-dependent selection system in Aureobasidium spp.
Non-conventional yeasts hold significant potential as biorefinery cell factories for microbial bioproduction. Currently, gene editing systems used for these yeasts rely on antibiotic and auxotrophic selection ...
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The Protective Role of Transcript-Induced in Spermiogenesis 40 in Cerebral Ischemia–Reperfusion Injury
Prompt reperfusion after cerebral ischemia is important to maintain neuronal survival and reduce permanent disability and death. However, the resupply of blood can induce oxidative stress, inflammatory respons...
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Antibonding orbital tailor and stress relief engineering for FeS2 complex toward superior sodium storage
The sluggish kinetics behaviors and vast volume variations of Na+ hosts to FeS2 anode involved intercalation, and conversion reactions plague its applicability of sodium-ion batteries (SIBs). Here, a significantl...
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Open AccessPrognostic value of the Naples prognostic score in patients with intrahepatic cholangiocarcinoma after hepatectomy
The Naples Prognostic Score (NPS), integrating inflammatory and nutritional biomarkers, has been reported to be associated with the prognosis of various malignancies, but there is no report on intrahepatic cho...
