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Article
Open AccessChronic prostatitis alters the prostatic microenvironment and accelerates preneoplastic lesions in C57BL/6 mice
Chronic prostatitis has been supposed to be associated with preneoplastic lesions and cancer development. The objective of this study was to examine how chronic inflammation results in a prostatic microenviron...
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Article
Genome-wide screening of hexokinase gene family and functional elucidation of HXK2 response to cold stress in Jatropha curcas
Hexokinase, the key rate-limiting enzyme of plant respiration and glycolysis metabolism, has been found to play a vital role in plant sugar sensing and sugar signal transduction. Using Jatropha curcas genome data...
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Article
The phytochrome-interacting family of transcription factors in maize (Zea mays L.): identification, evolution, and expression analysis
The phytochrome-interacting factor (PIF) subfamily of transcription factors is among the most important families of plant transcriptional regulators. PIFs regulate multiple biological processes, especially the...
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Article
Effects of chilling stress on the accumulation of soluble sugars and their key enzymes in Jatropha curcas seedlings
As osmolytes and signaling molecules, soluble sugars participate in the response and adaptation of plants to environmental stresses. In the present study, we measured the effect of chilling (12 °C) stress on t...
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Article
Differential influence of elevated CO2 on gas exchange and water use efficiency of four indigenous shrub species distributed in different sandy environments in central Inner Mongolia
In view of the increase in global warming and carbon dioxide (CO2) concentrations, it is essential to investigate the influences of climate change on plant growth and water use in arid and semi-arid grassland spe...
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Article
Roles of a maize phytochrome-interacting factors protein ZmPIF3 in regulation of drought stress responses by controlling stomatal closure in transgenic rice without yield penalty
ZmPIF3 plays an important role in ABA-mediated regulation of stomatal closure in the control of water loss, and can improve both drought tolerance and did not affect the grain yield in the transgenic rice.
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Article
Seaward migration behavior of juvenile second filial generation Chinese sturgeon Acipenser sinensis in the Yangtze River, China
Second filial generation (F2) Chinese sturgeon from hatcheries have been released to restock the endangered natural population of this fish ever since full-cycle artificial breeding was first achieved in 2009....
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Article
Retinoic acid ameliorates high-fat diet-induced liver steatosis through sirt1
In this study, treatment of C57BL/6J (wild type, WT) mice fed a high-fat diet (HFD) with retinoic acid (RA) decreased body weight and subcutaneous and visceral fat content, reversed the apparent hepatosteatosi...
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Article
Characterizing vertical migration of Microcystis aeruginosa and conditions for algal bloom development based on a light-driven migration model
Light-driven vertical migration is critical in dense aggregation of Microcystis aeruginosa during algal blooms under reduced turbulence conditions in natural water bodies. This study examined the vertical migrati...
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Article
Open AccessTransplanted human p75-positive stem Leydig cells replace disrupted Leydig cells for testosterone production
Previous studies have demonstrated that rodent stem Leydig cell (SLC) transplantation can partially restore testosterone production in Leydig cell (LC)-disrupted or senescent animal models, which provides a pr...
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Article
Open AccessIAPP modulates cellular autophagy, apoptosis, and extracellular matrix metabolism in human intervertebral disc cells
The pathogenic process of intervertebral disc degeneration (IDD) is characterized by imbalance in the extracellular matrix (ECM) metabolism. Nucleus pulposus (NP) cells have important roles in maintaining the ...
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Article
Open AccessPredPhos: an ensemble framework for structure-based prediction of phosphorylation sites
Post-translational modifications (PTMs) occur on almost all proteins and often strongly affect the functions of modified proteins. Phosphorylation is a crucial PTM mechanism with important regulatory functions...
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Article
Downregulation and tumor-suppressive role of XPO5 in hepatocellular carcinoma
XPO5 (Exp5, Exportin-5) is a transporter protein mainly mediating pre-microRNAs’ nuclear export. Recent studies have demonstrated that XPO5 may play crucial roles in a few of cancers. However, little is known ...
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Article
A FOXM1 related long non-coding RNA contributes to gastric cancer cell migration
Long non-coding RNAs (LncRNAs) have been reported that play important roles in the progression and metastasis of some carcinomas. In the present study, we identified a new LncRNA, FRLnc1, from a microarray ana...
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Article
MicroRNA expression profiles in conventional and micropropagated Dendrobium officinale
MicroRNA (miRNA) is defined as an endogenous ~22 nt noncoding RNA that has critical gene-regulatory functions in plants. Dendrobium officinale is among the most important herbs in traditional Chinese medicine. Ho...
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Article
A maize phytochrome-interacting factor 3 improves drought and salt stress tolerance in rice
Phytochrome-interacting factor 3 (PIF3) activates light-responsive transcriptional network genes in coordination with the circadian clock and plant hormones to modulate plant growth and development. However, ...
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Article
Open AccessAssociation study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population
Dyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling. Increasing evidence reveals that diff...
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Article
Fine map** of the qLOP2 and qPSR2-1 loci associated with chilling stress tolerance of wild rice seedlings
Using leaf osmotic potential and plant survival rate as chilling-tolerant trait indices, we identified two major quantitative trait loci qLOP2 and ...
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Article
Effects and Mechanism Analysis of Vascular Endothelial Growth Factor and Salvianolic Acid B on 125I-Low Density Lipoprotein Permeability of the Rabbit Aortary Endothelial Cells
Atherosclerosis is the common pathological basis of cardiovascular and cerebrovascular disease. This study aimed to investigate the effects of vascular endothelial growth factor (VEGF) and salvianolic acid B (...
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Article
Open AccessCharacterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction
The ability to identify and isolate lineage-specific stem cells from adult tissues could facilitate cell replacement therapy. Leydig cells (LCs) are the primary source of androgen in the mammalian testis, and ...