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Article
Open AccessCell graph neural networks enable the precise prediction of patient survival in gastric cancer
Gastric cancer is one of the deadliest cancers worldwide. An accurate prognosis is essential for effective clinical assessment and treatment. Spatial patterns in the tumor microenvironment (TME) are conceptual...
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Article
Nanoindentation characteristics of nanocrystalline B2 CuZr shape memory alloy via large-scale atomistic simulation
Nanoindentation tests are performed by molecular dynamics simulation to explore the mechanical properties of nanocrystalline B2 CuZr shape memory alloys with average grain sizes ranging from 6 to 18 nm. Some p...
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Article
Open AccessPenile surgery for patients with Peyronie’s disease initially treated with collagenase clostridium histolyticum or surgery: a claims database analysis
Collagenase clostridium histolyticum (CCH) is an injectable therapy targeting collagen present in penile plaques in Peyronie’s disease (PD). Data comparing CCH to penile surgery are limited, and long-term ther...
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Article
TESC promotes differentiated thyroid cancer development by activating ERK and weakening NIS and radioiodine uptake
Most differentiated thyroid cancer (DTC) patients have a good prognosis after surgery, but radioiodine refractory differentiated thyroid cancer (RAIR-DTC) patients have a significantly reduced 5-year survival ...
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Article
Fracture toughness and destructive mechanism of ductile nanoporous metallic glass and its crystal-impregnated nanocomposite
Nanoporous metallic glasses (NPMGs) and crystalline/amorphous nanocomposites exhibit superior ductility over bulk macroscopic metallic glasses (MGs). Their fracture behaviors remain a mystery due to experiment...
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Article
Open AccessInflammasome activity is controlled by ZBTB16-dependent SUMOylation of ASC
Inflammasome activity is important for the immune response and is instrumental in numerous clinical conditions. Here we identify a mechanism that modulates the central Caspase-1 and NLR (Nod-like receptor) ada...
