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Article
Open AccessDownregulated developmental processes in the postnatal right ventricle under the influence of a volume overload
The molecular atlas of postnatal mouse ventricular development has been made available and cardiac regeneration is documented to be a downregulated process. The right ventricle (RV) differs from the left ventr...
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Article
Open AccessLncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA
Granulosa cell (GC) is a critical somatic component of ovarian follicles to support oocyte development, while the regulatory role of long noncoding RNA (lncRNA) in GCs is largely unknown. Here, we identified a...
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Article
Open AccessFecal microbiota transplantation from patients with autoimmune encephalitis modulates Th17 response and relevant behaviors in mice
The significance of the microbiota-gut-brain axis has been increasingly recognized as a major modulator of autoimmunity. Here, we aim to characterize the gut microbiota of a large cohort of treatment-naïve anti-N
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Article
Open AccessFate decision of satellite cell differentiation and self-renewal by miR-31-IL34 axis
Quiescent satellite cells (SCs) that are activated to produce numerous myoblasts underpin the complete healing of damaged skeletal muscle. How cell-autonomous regulatory mechanisms modulate the balance among c...
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Article
Open AccessLncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury
Ischemia-reperfusion (I/R) is a common pathology when the blood supply to an organ was disrupted and then restored. During the reperfusion process, inflammation and tissue injury were triggered, which were med...
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Article
Open AccessYL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells
Aberrant activation of signal transducer and activator of transcription 3 (STAT3) plays a critical role in the proliferation and survival of multiple myeloma. And inactivation of STAT3 is considered a promisin...
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Article
Open AccessRIP3 is an upregulator of aerobic metabolism and the enhanced respiration by necrosomal RIP3 feeds back on necrosome to promote necroptosis