111 Result(s)

Article

Aminoprocalcitonin protects against hippocampal neuronal death via preserving oxidative phosphorylation in refractory status epilepticus

Refractory status epilepticus (RSE) is a neurological emergency where sustaining seizure causes severe neuronal death. Currently, there is no available neuroprotectant effective in RSE. Aminoprocalcitonin (NPC...

Changgeng Song, **g**g Zhao, Jianmin Hao, Dan Mi, Jiajia Zhang… in Cell Death Discovery (2023)

Article

Correction to: NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

Yi Wang, Yuxin Zan, Yingying Huang, **aoyun Peng, Shinan Ma, Ji Ren… in Cell Death Discovery (2023)

Article

JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a chronic disorder characterized by hyperproliferation of pulmonary arterial smooth muscle cells (PASMCs). JMJD1C, a member of the Jumonji domain containing C (JMJC) hi...

Chen Zhang, Yue Sun, Yingying Guo, **g**g Xu, Haiyan Zhao in Cell Death Discovery (2023)

Article

Correction to: LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury

Peixing Wan, Wenru Su, Yingying Zhang, Zhidong Li… in Cell Death & Differentiation (2023)

Article

Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection

Bo Gao, Liheng He, Yujie Bao, Yingying Chen, Guanzhu Lu, Yu Zhang… in Cell Research (2023)

Article

NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

Doxorubicin (DOX) is a commonly used antitumor drug, but its application has been limited because of its strong cardiac damage. This study aims to explore the role of NSUN2 in DOX-induced heart injury. C57BL/6...

Yi Wang, Yuxin Zan, Yingying Huang, **aoyun Peng, Shinan Ma, Ji Ren… in Cell Death Discovery (2023)

Article

Hepatocyte-specific TMEM16A deficiency alleviates hepatic ischemia/reperfusion injury via suppressing GPX4-mediated ferroptosis

Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major complication of liver transplantation. Transmembrane member 16A (TMEM16A), a component of hepatocyte Ca²⁺-activated chloride chann...

Jiawei Guo, Zihao Song, Jie Yu, Chengyi Li, Chenchen **, Wei Duan… in Cell Death & Disease (2022)

Article

Role of peripheral immune cells in spinal cord injury

Secondary spinal cord injury is caused by an inflammatory response cascade, and the process is irreversible. The immune system, as a mediator of inflammation, plays an important role in spinal cord injury. The...

Cong Li, Wu **ong, Bowen Wan, Guang Kong… in Cellular and Molecular Life Sciences (2022)

Article

Oxidative degradation of dihydrofolate reductase increases CD38-mediated ferroptosis susceptibility

High expression of CD38 in tissues is a characteristic of aging, resulting in a decline in nicotinamide adenine dinucleotide (NAD) and increasing cellular reactive oxygen species (ROS). However, whether CD38 i...

Yingying Ma, Meiqi Yi, Weixuan Wang, **aohui Liu, Qingtao Wang… in Cell Death & Disease (2022)

Article

Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop

Triple-negative breast cancer (TNBC), an aggressive histological subtype of breast cancer, exhibits a high risk of early recurrence rate and a poor prognosis, and it is primarily associated with the abundance ...

Yingying Shen, Qingyun Zhu, Maoyu **ao, Liyang Yin, Wenjie Feng… in Cell Death & Disease (2022)

Article

Human-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest

Exploring the functions of human-specific genes (HSGs) is challenging due to the lack of a tractable genetic model system. Testosterone is essential for maintaining human spermatogenesis and fertility, but the...

Chao Li, Yuming Feng, Zhenxin Fu, Junjie Deng, Yue Gu, Hanben Wang… in Cell Death Discovery (2022)

Article

FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia

Hypoxic pulmonary hypertension (PH) is a progressive disease characterized by hyper-proliferation of pulmonary vascular cells including pulmonary artery smooth muscle cells (PASMCs) and can lead to right heart...

Ruxia Liu, Chunling Xu, Weilin Zhang, Yangpo Cao, **g**g Ye… in Cell Death & Disease (2022)

Article

Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression

Prostate cancer (PCa) is a malignant tumor that seriously threatens men’s health worldwide. Recently, stromal cells in the tumor microenvironment (TME) have been reported to contribute to the progression of PC...

Tianqi Wu, Wenfeng Wang, Guohai Shi, Mingang Hao, Yingying Wang… in Cell Death & Disease (2022)

Article

RBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator

The mechanisms by which the tumor behaviors of hepatocellular carcinoma (HCC) support growth and metastasis remain largely unknown, and it has become increasingly apparent that molecular dysregulation is of co...

Tao Guo, Ke You, ** Chen, Yuqi Sun, Ying Wu, ** Wu… in Cell Death Discovery (2022)

Article

Gankyrin modulated non-small cell lung cancer progression via glycolysis metabolism in a YAP1-dependent manner

Non-small cell lung cancer (NSCLC) is highly malignant and heterogeneous form of lung cancer and involves various oncogene alterations. Glycolysis, an important step in tumor metabolism, is closely related to ...

Tong Yu, Yanyan Liu, Junwen Xue, **ang Sun, Di Zhu, Lu Ma… in Cell Death Discovery (2022)

Article

Z-DNA is remodelled by ZBTB43 in prospermatogonia to safeguard the germline genome and epigenome

Mutagenic purine–pyrimidine repeats can adopt the left-handed Z-DNA conformation. DNA breaks at potential Z-DNA sites can lead to somatic mutations in cancer or to germline mutations that are transmitted to th...

Yingying Meng, Guliang Wang, Hongjuan He, Kin H. Lau, Allison Hurt… in Nature Cell Biology (2022)

Article

Systematic analyses identify the anti-fibrotic role of lncRNA TP53TG1 in IPF

Long non-coding RNA (lncRNA) was reported to be a critical regulator of cellular homeostasis, but poorly understood in idiopathic pulmonary fibrosis (IPF). Here, we systematically identified a crucial lncRNA, ...

Jian Sun, Yingying Guo, Tingting Chen, Tongzhu **, Lu Ma… in Cell Death & Disease (2022)

Article

DNAJC24 is a potential therapeutic target in hepatocellular carcinoma through affecting ammonia metabolism

Evolutionarily conserved heat shock proteins are involved in the heat shock response of cells in response to changes in the external environment. In normal tissues, heat shock proteins can help cells survive i...

Guangtao Li, Yuchao He, Hui Liu, Dongming Liu, Lu Chen, Yi Luo… in Cell Death & Disease (2022)

Article

Hypoxia-induced NFATc3 deSUMOylation enhances pancreatic carcinoma progression

The transcriptional regulator nuclear factor of activated T-cells, cytoplasmic 3 (NFATc3) is constitutively activated in several cancer types and plays important roles in cancer development and progression. He...

Yingying Tong, Zheng Zhang, Yurong Cheng, **g Yang, Cong Fan… in Cell Death & Disease (2022)

Article

Reticulon 2 promotes gastric cancer metastasis via activating endoplasmic reticulum Ca²⁺ efflux-mediated ERK signalling

Gastric cancer ranks fourth for mortality globally among various malignant tumours, and invasion and metastasis are the major reason leading to its poor prognosis. Recently, accumulating studies revealed the r...

Shushu Song, Bo Liu, **aoqing Zeng, Yingying Wu, Hao Chen, Hao Wu… in Cell Death & Disease (2022)