41 Result(s)

Article

Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection

A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is urgently needed to tackle the COVID-19 global pandemic. Here, we describe the development of chimpanzee adenovir...

Jiaojiao Liu, Kun Xu, Man **ng, Yue Zhuo, **gao Guo, Meng Du, Qi Wang… in Cell Discovery (2021)

Article

Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals

SARS-CoV-2 outbreak has been declared by World Health Organization as a worldwide pandemic. However, there are many unknowns about the antigen-specific T-cell-mediated immune responses to SARS-CoV-2 infection....

Lingjie Luo, Wenhua Liang, Jianfeng Pang, Gang Xu, Yingying Chen… in Cell Discovery (2021)

Article

Generation of human blastocyst-like structures from pluripotent stem cells

Human blastocysts are comprised of the first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm, all of which are essential for early development and organ formation. However, du...

Yong Fan, Zheying Min, Samhan Alsolami, Zhenglai Ma, E. Zhang, Wei Chen… in Cell Discovery (2021)

Article

Downregulated developmental processes in the postnatal right ventricle under the influence of a volume overload

The molecular atlas of postnatal mouse ventricular development has been made available and cardiac regeneration is documented to be a downregulated process. The right ventricle (RV) differs from the left ventr...

Chunxia Zhou, Sijuan Sun, Mengyu Hu, Yingying **ao, **afeng Yu… in Cell Death Discovery (2021)

Article

LncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA

Granulosa cell (GC) is a critical somatic component of ovarian follicles to support oocyte development, while the regulatory role of long noncoding RNA (lncRNA) in GCs is largely unknown. Here, we identified a...

Duan Li, **aoyan Wang, Guangyu Li, Yujie Dang, Shidou Zhao… in Cell Death Discovery (2021)

Article

Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations

Substitution of lysine 36 with methionine in histone H3.3 (H3.3K36M) is an oncogenic mutation that inhibits SETD2-mediated histone H3K36 tri-methylation in tumors. To investigate how the oncohistone mutation a...

Yingying Liu, Yanjun Zhang, Han Xue, Mi Cao, Guohui Bai, Zongkai Mu… in Cell Discovery (2021)

Article

Author Correction: Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans

A Correction to this paper has been published: https://doi.org/10.1038/s41421-021-00251-8

Tianbin Liu, Jie Li, Leqian Yu, Hai-** Sun, **g Li, Guoyi Dong… in Cell Discovery (2021)

Article

Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans

Interspecies blastocyst complementation enables organ-specific enrichment of xenogeneic pluripotent stem cell (PSC) derivatives, which raises an intriguing possibility to generate functional human tissues/orga...

Tianbin Liu, Jie Li, Leqian Yu, Hai-** Sun, **g Li, Guoyi Dong… in Cell Discovery (2021)

Article

Sensitivity and specificity of SARS-CoV-2 S1 subunit in COVID-19 serology assays

Ying Tian, Chaoyang Lian, Yingying Chen, Dong Wei, **nxin Zhang, Yun Ling… in Cell Discovery (2020)

Article

USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment

Previous studies have implicated an essential role for UHRF1-mediated histone H3 ubiquitination in recruiting DNMT1 to replication sites for DNA maintenance methylation during S phase of the cell cycle. Howeve...

Jialun Li, Rui** Wang, Jianyu **, Mengmeng Han, Zhaosu Chen… in Cell Discovery (2020)

Article

Fecal microbiota transplantation from patients with autoimmune encephalitis modulates Th17 response and relevant behaviors in mice

The significance of the microbiota-gut-brain axis has been increasingly recognized as a major modulator of autoimmunity. Here, we aim to characterize the gut microbiota of a large cohort of treatment-naïve anti-N

Hao Chen, Zhaoyu Chen, Li** Shen, **uhua Wu, Xueying Ma… in Cell Death Discovery (2020)

Article

Fate decision of satellite cell differentiation and self-renewal by miR-31-IL34 axis

Quiescent satellite cells (SCs) that are activated to produce numerous myoblasts underpin the complete healing of damaged skeletal muscle. How cell-autonomous regulatory mechanisms modulate the balance among c...

Yang Su, Yingying Yu, Chuncheng Liu, Yuying Zhang… in Cell Death & Differentiation (2020)

Article

LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury

Ischemia-reperfusion (I/R) is a common pathology when the blood supply to an organ was disrupted and then restored. During the reperfusion process, inflammation and tissue injury were triggered, which were med...

Peixing Wan, Wenru Su, Yingying Zhang, Zhidong Li… in Cell Death & Differentiation (2020)

Article

Efficient engulfment of necroptotic and pyroptotic cells by nonprofessional and professional phagocytes

Jiongcong Lu, Wenke Shi, Bo Liang, Chang’an Chen, Rui Wu, Huaipeng Lin… in Cell Discovery (2019)

Article

Hemi-methylated CpG sites connect Dnmt1-knockdown-induced and Tet1-induced DNA demethylation during somatic cell reprogramming

The relationship between active DNA demethylation induced by overexpressing Tet1 and passive DNA demethylation induced by suppressing Dnmt1 remains unclear. Here, we found that DNMT1 preferentially methylated, bu...

Songwei He, Fuhui Wang, Yixin Zhang, **long Chen, Lining Liang, Yuan Li… in Cell Discovery (2019)

Article

YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells

Aberrant activation of signal transducer and activator of transcription 3 (STAT3) plays a critical role in the proliferation and survival of multiple myeloma. And inactivation of STAT3 is considered a promisin...

Yingying Wang, Linlin Wu, Haiyan Cai, Hu Lei, Chun-Min Ma, Li Yang… in Cell Death Discovery (2018)

Article

RIP3 is an upregulator of aerobic metabolism and the enhanced respiration by necrosomal RIP3 feeds back on necrosome to promote necroptosis

**ngfeng Qiu, Yingying Zhang, Jiahuai Han in Cell Death & Differentiation (2018)

Article

Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice

SLC39A14 (also known as ZIP14), a member of the SLC39A transmembrane metal transporter family, has been reported to mediate the cellular uptake of iron and zinc. Recently, however, mutations in the SLC39A14 gene ...

Yongjuan **n, Hong Gao, Jia Wang, Yuzhen Qiang, Mustapha Umar Imam… in Cell Discovery (2017)

Article

Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation

Out of the breast cancer subtypes, triple-negative breast cancer (TNBC) has the poorest prognosis without effective targeted therapies. Metformin, a first-line drug for type 2 diabetes mellitus, was demonstrat...

Peiguo Shi, Wen**g Liu, Tala, Haixia Wang, Fubing Li, Hailin Zhang… in Cell Discovery (2017)

Article

Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity

Wnt/β-catenin signaling regulates multiple biological processes and aberration of this pathway is frequently observed in human cancers. Previously, we uncovered NC043 as a small-molecule inhibitor of Wnt/β-cat...

**aoli He, Wenjuan Zhang, Chen Yan, Fen Nie, Chen Li, **aofen Liu… in Cell Discovery (2017)