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Article
Open AccessEarly pathophysiology-driven airway pressure release ventilation versus low tidal volume ventilation strategy for patients with moderate-severe ARDS: study protocol for a randomized, multicenter, controlled trial
Conventional Mechanical ventilation modes used for individuals suffering from acute respiratory distress syndrome have the potential to exacerbate lung injury through regional alveolar overinflation and/or rep...
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Article
Open AccessEstablishment of an efficient regeneration system of ‘ZiKui’ tea with hypocotyl as explants
Zikui (Camellia sinensis cv. Zikui) is a recently discovered cultivar of local purple tea in Guizhou, China. It is a purple leaf bud mutation material of Meitan Taicha (Camellia sinensis cv. ‘Meitan-taicha’) ‘N61...
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Article
SPG21, a potential oncogene targeted by miR-128-3p, amplifies HBx-induced carcinogenesis and chemoresistance via activation of TRPM7-mediated JNK pathway in hepatocellular carcinoma
Chronic hepatitis B virus (HBV) infection is the primary risk factor for the malignant progression of hepatocellular carcinoma (HCC). It has been reported that HBV X protein (HBx) possesses oncogenic propertie...
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Article
Open AccessA time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues
High-altitude hypoxia acclimatization requires whole-body physiological regulation in highland immigrants, but the underlying genetic mechanism has not been clarified. Here we use sheep as an animal model for ...
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Article
Open AccessIntegrative analyses of bulk and single-cell transcriptomics reveals the infiltration and crosstalk of cancer-associated fibroblasts as a novel predictor for prognosis and microenvironment remodeling in intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICC) is a highly malignant neoplasm and characterized by desmoplastic matrix. The heterogeneity and crosstalk of tumor microenvironment remain incompletely understood.
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Article
Trajectory patterns and cumulative burden of CEA during follow-up with non-small cell lung cancer outcomes: A retrospective longitudinal cohort study
Previous studies of non-small cell lung cancer (NSCLC) focused on CEA measured at a single time point, ignoring serial CEA measurements.
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Article
Performance on adsorption of toluene by ionic liquid-modified AC in high-humidity exhaust gas
Volatile organic compounds (VOCs) frequently pose a threat to the biosphere, impacting ecosystems, flora, fauna, and the surrounding environment. Industrial emissions of VOCs often include the presence of wate...
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Article
Open AccessA retrospective clinical analysis of 11 cases of PEComa from different sites
The objective of this paper is to offer a thorough examination of the clinical presentations, etiology, and treatment strategies associated with perivascular epithelioid cell tumors (PEComas).
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Article
Open AccessGenetic introgression from commercial European pigs to the indigenous Chinese Lijiang breed and associated changes in phenotypes
Gene flow is crucial for enhancing economic traits of livestock. In China, breeders have used hybridization strategies for decades to improve livestock performance. Here, we performed whole-genome sequencing o...
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Article
Open AccessA comprehensive review of pedestrian re-identification based on deep learning
Pedestrian re-identification (re-ID) has gained considerable attention as a challenging research area in smart cities. Its applications span diverse domains, including intelligent transportation, public securi...
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Article
Open AccessFerroptosis contributing to cardiomyocyte injury induced by silica nanoparticles via miR-125b-2-3p/HO-1 signaling
Amorphous silica nanoparticles (SiNPs) have been gradually proven to threaten cardiac health, but pathogenesis has not been fully elucidated. Ferroptosis is a newly defined form of programmed cell death that i...
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Article
Long Non-Coding RNA ANRIL Regulates Inflammatory Factor Expression in Ulcerative Colitis Via the miR-191-5p/SATB1 Axis
Ulcerative colitis, an inflammatory bowel disease, manifests with symptoms such as abdominal pain, diarrhea, and mucopurulent feces. The long non-coding RNA (lncRNA) ANRIL exhibits significantly reduced expres...
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Article
Root cause of corrosion failure of tin coating on wire clamp in marine atmosphere
The failure cause of a tinned copper wire clamp in marine atmosphere was studied systematically by X-ray photoelectron spectroscopy, scanning electron microscopy with energy dispersive spectroscopy and electro...
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Article
Development and application of a fully automatic multi-function cassette module Mortenon M1 for radiopharmaceutical synthesis
Functions of existing automatic module systems for synthesis of radiopharmaceuticals mainly focus on the radiolabeling of small molecules. There are few modules which have achieved full-automatic radiolabeling...
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Article
Open AccessEffect of hydroxychloroquine blood concentration on the efficacy and ocular toxicity of systemic lupus erythematosus
In the absence of evidence-based guidance on the impact of hydroxychloroquine (HCQ) blood concentration on efficacy and ocular toxicity in systemic lupus erythematosus (SLE), the clinical monitoring of HCQ blo...
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Article
A review: recent advances in the application of 3D printing biomaterials in breast reconstruction research
Breast reconstruction is an indispensable component of surgical treatment for breast cancer. Currently, implant-based breast reconstruction (IBBR) has become a primary method, utilizing prosthetic implants. Th...
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Article
Two-partite entanglement purification assisted by quantum-dot spins inside single-sided optical microcavities
Entanglement purification is an important and useful tool in quantum communications that allows parties to enhance the entanglement of a set of less-entangled particles using local operations and classical com...
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Article
Open AccessOptimizing LI-RADS: ancillary features screened from LR-3/4 categories can improve the diagnosis of HCC on MRI
To determine the high-efficiency ancillary features (AFs) screened from LR-3/4 lesions and the HCC/non-HCC group and the diagnostic performance of LR3/4 observations.
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Article
Open AccessIntegrative metagenomic and metabolomic analyses reveal the potential of gut microbiota to exacerbate acute pancreatitis
Early dysbiosis in the gut microbiota may contribute to the severity of acute pancreatitis (AP), however, a comprehensive understanding of the gut microbiome, potential pathobionts, and host metabolome in indi...
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Article
Open AccessProteomic characterization of esophageal squamous cell carcinoma response to immunotherapy reveals potential therapeutic strategy and predictive biomarkers
Immunotherapy is the first-line therapy for esophageal squamous cell carcinoma (ESCC), yet many patients do not respond due to drug resistance and the lack of reliable predictive markers. We collected 73 ESCC ...
