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Article
Investigation of the mutual crosstalk between ER stress and PI3K/AKT/mTOR signaling pathway in iron overload-induced liver injury in chicks
Iron is an essential element for the normal functioning of living organisms, but excessive iron deposition can lead to organ damage. This study aims to investigate the interaction between the endoplasmic retic...
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Article
Synergistically enhancing electrocatalysis and non-enzymatic sensing for glucose by iridium single-atom/nickel oxide/N-doped graphene
The development of novel catalyst with high catalytic activity is important for electrochemical non-enzymatic glucose sensing. Here, iridium single-atom/nickel oxide nanoparticle/N-doped graphene nanosheet (Ir1/N...
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Article
Open AccessFull-waveform tomography reveals iron spin crossover in Earth’s lower mantle
Three-dimensional models of Earth’s seismic structure can be used to identify temperature-dependent phenomena, including mineralogical phase and spin transformations, that are obscured in 1-D spherical average...
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Article
Open AccessChallenges and strategies associated with CAR-T cell therapy in blood malignancies
Cellular immunotherapy, particularly CAR-T cells, has shown potential in the improvement of outcomes in patients with refractory and recurrent malignancies of the blood. However, achieving sustainable long-ter...
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Article
Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β signaling
Tumor-derived exosomes (TEXs) enriched in immune suppressive molecules predominantly drive T-cell dysfunction and impair antitumor immunity. Chimeric antigen receptor (CAR) T-cell therapy has emerged as a prom...
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Article
Effect of exposures to multiple metals on blood pressure and hypertension in the elderly: a community-based study
A chronic disease, hypertension (HTN) is prevalent among the elderly. Exploring the factors that influence HTN and blood pressure (BP) changes is of great public health significance. However, mixed exposure to...
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Article
Open AccessA nonhuman primate model with Alzheimer’s disease-like pathology induced by hippocampal overexpression of human tau
Alzheimer’s disease (AD) is one of the most burdening diseases of the century with no disease-modifying treatment at this time. Nonhuman primates (NHPs) share genetic, anatomical, and physiological similaritie...
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Article
Open AccessPrediction of positive pulmonary nodules based on machine learning algorithm combined with central carbon metabolism data
Lung cancer causes a huge disease burden, and early detection of positive pulmonary nodules (PPNs) as an early sign of lung cancer is extremely important for effective intervention. It is necessary to develop ...
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Article
High incidence of EDNRB gene mutation in seven southern Chinese familial cases with Hirschsprung’s disease
Hirschsprung’s disease (HSCR) is the leading cause of neonatal functional intestinal obstruction, which has been identified in many familial cases. HSCR, a multifactorial disorder of enteric nervous system (EN...
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Article
Open AccessReduced thoracic skeletal muscle size is associated with adverse outcomes in diabetes patients with heart failure and reduced ejection fraction: quantitative analysis of sarcopenia by using cardiac MRI
Sarcopenia is frequently found in patients with heart failure with reduced ejection fraction (HFrEF) and is associated with reduced exercise capacity, poor quality of life and adverse outcomes. Recent evidence...
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Article
Open AccessSafety and feasibility of anti-CD19 CAR T cells expressing inducible IL-7 and CCL19 in patients with relapsed or refractory large B-cell lymphoma
Although CD19-specific chimeric antigen receptor (CAR) T cells are curative for patients with relapsed or refractory large B-cell lymphoma (R/R LBCL), disease relapse with tumor antigen-positive remains a chal...
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Article
Open AccessEfficacy, safety, and predictive model of Palbociclib in the treatment of HR-positive and HER2-negative metastatic breast cancer
This research designeded to: 1. Analyze the efficacy and safety of Palbociclib treatment in HR-positive and HER2-negative (HR + /HER2-) metastatic breast cancer(MBC) patients. 2. Establish and validate a nomog...
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Chapter and Conference Paper
Application of Adaptive VMD Algorithm in High-Speed Rail Seismic Signal Extraction
When a high-speed train is in motion, it causes vibrations in the railway tracks, resulting in seismic waves. However, the actual collected data also includes background noise from the Earth and various human ...
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Chapter and Conference Paper
Elastic Full Waveform Inversion Based on the High-Speed Rail Seismic Source
With the establishment of a widely distributed and dense high-speed rail network, high-speed rail will be spread all over China in the near future. Research shows that high-speed rail seismic waves contain ric...
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Chapter and Conference Paper
An Improved DBO Algorithm Applying for Numerical Modelling Under the Asymmetric Wave Equations
The asymmetric wave equation encompasses the influence of the actual fine structure inside the medium on the wave field, which can better represent the complex seismic wavefield excited by the complex source a...
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Chapter
Defect Engineering in Epitaxially Grown Cd(Zn)Te Thin Films on Lattice-Mismatch Substrates
II–VI (Hg)(Cd)(Zn)Te semiconductors are significant materials with a wide range of applications in high-end infrared (IR) sensing/imaging, radiation detectors, and solar cells. However, due to the soft and bri...
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Chapter and Conference Paper
Design and Fabricated on 0.67-THz Folded Waveguide Circuit
In this paper, a 0.67-THz folded waveguide (FW) circuit has been simulated and tested. The slow wave structure (SWS) has been optimized for working in the frequency range of 0.66–0.68THz. The performance of th...
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Article
A Highly Transparent Self-Powered Touch Sensor Based on Hierarchical (Micro-Nano) Cu Grid on Polyethylene Terephthalate Composite Electrodes for Smart Wear
With the expansion of the applications of sensors, requirements such as flexibility, visual transparency, and self-powering have become critical. In this work, firstly we have adopted photoetch and hierarchica...
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Article
Biosensors based on potent miniprotein binder for sensitive testing of SARS-CoV‑2 variants of concern
The miniprotein binder TRI2-2 was employed as an antibody alternative to build a single antibody-coupled TRI2-2 based gold nanoparticle-based lateral flow immunoassay (AT–GLFIA) biosensor. The biosensor provid...
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Article
A Hybrid Dung Beetle Optimization Algorithm with Simulated Annealing for the Numerical Modeling of Asymmetric Wave Equations
In the generalized continuum mechanics (GCM) theory framework, asymmetric wave equations encompass the characteristic scale parameters of the medium, accounting for microstructure interactions. This study inte...
