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Article
Prostate cancer incidence varies among males from different Y-chromosome lineages
The incidence rate of prostate cancer in African-American males is two times higher than Caucasian men and ten times higher than Japanese men. The geographical specificity of Y haplogroups implies that males f...
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Article
Open AccessDiversity of Cl− Channels
Cl− channels are widely found anion pores that are regulated by a variety of signals and that play various roles. On the basis of molecular biologic findings, ligand-gated Cl− channels in synapses, cystic fibrosi...
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Article
The effect of γ-tocopherol administration on α-tocopherol levels and metabolism in humans
The bioavailability of γ-tocopherol and metabolites of vitamin E after γ-tocopherol administration is not well understood. We investigated the effect of γ-tocopherol administration on the levels and metabolism of...
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Article
Differences in MR features of the substantia innominata between dementia with Lewy bodies and Alzheimer’s disease
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Article
Unusual reactions of isolable dialkylgermylene and -stannylene with galvinoxyl radical
The reactions of isolable dialkylgermylene and -stannylene with a galvinoxyl radical were found to give rather unusual cyclic compounds in high yields via intermediate adduct radicals. The structures of the cycli...
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Article
Expression of an Artificial Cl− Channel in Microperfused Renal Proximal Tubules
To better understand the process of fluid movement driven by Cl− conductance, a Cl− channel-forming peptide was delivered to the luminal membrane of microperfused rabbit renal proximal tubules. When the peptide (...
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Article
A stable silicon-based allene analogue with a formally sp-hybridized silicon atom
Carbon chemistry exhibits a rich variety in bonding patterns, with homo- or heteronuclear multiple bonds involving sp-hybridized carbon atoms as found in molecules such as acetylenes, nitriles, allenes and carbon...
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Article
Structural Implications of Placing Cationic Residues at either the NH2- or COOH-Terminus in a Pore-forming Synthetic Peptide
Restoration of chloride conductance via introduction of an anion-selective pore, formed by a channel-forming peptide, has been hypothesized as a novel treatment modality for patients with cystic fibrosis. Deli...
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Article
Antitumor activity of a phenoxazine compound, 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one against human B cell and T cell lymphoblastoid cell lines: induction of mixed types of cell death, apoptosis, and necrosis
Abstract
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Article
Chemical diversity in lipopeptide antifungal antibiotics
In the course of screening for antifungal antibiotics, we have discovered a novel series of lipopeptide compounds structurally related to, but highly superior to, echinocandin B in terms of their water solubil...
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Article
Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family
A full-length cDNA encoding a novel protein was isolated and sequenced from a human placental cDNA library. This cDNA consists of 1735 base pairs and has a predicted open reading frame (ORF) encoding 354 amin...
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Article
Potential factors regulating serum parathyroid hormone in maintenance hemodialysis patients: 4-year retrospective study
Background. This study was carried out to evaluate potential factors affecting long-term parathyroid function in patients on maintenance hemodialysis.
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Article
Lithium activates mammalian Na+/H+ exchangers: isoform specificity and inhibition by genistein
Replacement of external NaCl with LiCl induced cytoplasmic alkalinization in CCL-39 cells and rat L6 myoblasts expressing the endogenous Na+/H+ exchanger isoform NHE1. This Li+-induced alkalinization is due to a...
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Article
Structure of the catena-bis(trimethylamine)cadmium(II)-tetra-μ-cyanonickelate(II) complex and contact self-stabilization of molecules
The [Cd(N(CH3)3)2Ni(CN)4] complex crystallizes in a tetragonal system, space group 14/mmm with two formula units per unit cell (XRD, Rigaku AFC-6A diffractometer, λ MoKα, ω/2θ scan mode, θmax = 38ℴ, 635 observed ...
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Article
Crystal structure of the Hofmann-dma type clathrate
Seven new Hofmann-dma type clathrates Cd(dma)2Ni(CN)4-xG (x = 1, G = aniline, 2,3-xylidine, 2,4-xylidine, 2,5-xylidine, 2,6-xylidine, 3,5-xylidine and x = 2, G = 2,4,6-trim ethylaniline) were prepared by replacin...
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Article
Effect of radiotherapy on anorectal function in patients with cervical cancer
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Article
Whole-cell currents from the cloned canine cardiac Na+/Ca2+ exchanger NCX1 overexpressed in a fibroblast cell CCL39
A conventional patch-clamp technique was used to record the whole-cell current from the cloned canine cardiac Na+/Ca2+ exchanger NCX1 overexpressed in a fibroblast cell. Ca2+ was extracellularly applied to the N...
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Article
Bioactivity of sol–gel derived organically modified silicates: Part I: In vitro examination
Bioactivity was investigated for several organically modified silicates (Ormosils) prepared through sol–gel processes. Ca(II)-free samples were biocompatible only, but Ca(II)containing samples were bioactive a...
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Article
Influence of Si Substrate Crystallinity on Device Performance
We have demonstrated the influence of surface microroughness on the electrical characteristics of MOS devices and investigated the influence of wafer’s manufacturing methods, such as Czochralski(Cz), floating-...
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Article
Synthesis of Bioactive Ormosils by the Sol-Gel Method
Bioactive ORMOSILS (Organically Modified Silicates) were synthesized by a sol-gel method, with tetraethoxysilane (TEOS) and polydimethylsiloxane (PDMS). Ca(II) ions were incorporated into the ormosil monoliths...
