56 Result(s)
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Stem Cells
Rui-** **ao
Life Sciences
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Article
Open AccessIdentification of oligosaccharyltransferase as a host target for inhibition of SARS-CoV-2 and its variants
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Open AccessThe METTL3/MALAT1/PTBP1/USP8/TAK1 axis promotes pyroptosis and M1 polarization of macrophages and contributes to liver fibrosis
Pro-inflammatory M1 macrophages, via activating hepatic stellate cells, contribute to liver fibrosis. In this study, we examined the mechanism and the significance of a signaling axis, METTL3/MALAT1/PTBP1/USP8...
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Open AccessA single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy
Metastasis is the primary cause of cancer-related mortality in colorectal cancer (CRC) patients. How to improve therapeutic options for patients with metastatic CRC is the core question for CRC treatment. Howe...
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Open AccessDipeptidyl peptidase-4 (DPP4) inhibitor sitagliptin alleviates liver inflammation of diabetic mice by acting as a ROS scavenger and inhibiting the NFκB pathway
As a common chronic metabolic disease, the development of diabetes mellitus (DM) may also be accompanied by liver damage and inflammatory disorders. Sitagliptin is an inhibitor of dipeptidyl peptidase-4 (DPP4,...
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Open AccessGlycemic control by umbilical cord-derived mesenchymal stem cells promotes effects of fasting-mimicking diet on type 2 diabetic mice
Hepatic steatosis is a big hurdle to treat type 2 diabetes (T2D). Fasting-mimicking diet (FMD) has been shown to be an effective intervention in dyslipidemia of T2D. However, fasting may impair the normal gluc...
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Open AccessSARS-CoV-2 infection in the mouse olfactory system
SARS-CoV-2 infection causes a wide spectrum of clinical manifestations in humans, and olfactory dysfunction is one of the most predictive and common symptoms in COVID-19 patients. However, the underlying mecha...
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Open AccessClinical-grade human dental pulp stem cells suppressed the activation of osteoarthritic macrophages and attenuated cartilaginous damage in a rabbit osteoarthritis model
Although increasing evidence has demonstrated that human dental pulp stem cells (hDPSCs) are efficacious for the clinical treatment of skeletal disorders, the underlying mechanisms remain incompletely understo...
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Open AccessMesenchymal stem cells regulate the Th17/Treg cell balance partly through hepatocyte growth factor in vitro
Mesenchymal stem cells (MSCs) exert immunomodulatory functions by inducing the development and differentiation of naive T cells into T cells with an anti-inflammatory regulatory T cell (Treg) phenotype. Our pr...
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CaMKII-δ9 promotes cardiomyopathy through disrupting UBE2T-dependent DNA repair
Ca2+/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase family, and its δ isoform is predominant in the heart. Excessive CaMKII activation plays a pivotal role in the pathogenesi...
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Open AccessCorrection to: Prof. Huan-Yong Chen: a leading botanist and taxonomist, one of the pioneers and founders of modern plant taxonomy in China
In the original publication, there are some incorrect information.
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Open AccessAuthor Correction: CRISPR-Cas12a-assisted nucleic acid detection
In the original version of the Supplementary Information file associated with this Article, the site ‘rs5082’ was incorrectly given and should be corrected to ‘rs5028’.
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Open AccessA chemical approach for global protein knockdown from mice to non-human primates
Although conventional genetic modification approaches for protein knockdown work very successfully due to the increasing use of CRISPR/Cas9, effective techniques for achieving protein depletion in adult animal...
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Open AccessA two-microRNA-based signature predicts first-line chemotherapy outcomes in advanced colorectal cancer patients
Prognostic and predictive markers are needed to predict the clinical outcomes of patients with advanced colorectal cancer (CRC) who receive standard first-line treatments. We performed a prospective cohort stu...
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Open AccessArchitecture of SWI/SNF chromatin remodeling complex
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Open AccessADRB2 polymorphism Arg16Gly modifies the natural outcome of heart failure and dictates therapeutic response to β-blockers in patients with heart failure
We sought to investigate the association of single nucleotide polymorphisms (SNPs) of the genes involved in βAR signaling with the response of patients to βAR blockers. A total of 2403 hospitalized patients wi...
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Open AccessCorrection to: Treatment of periodontal intrabony defects using autologous periodontal ligament stem cells: a randomized clinical trial
The original article [1] contains a major error carried across the captions of Tables 1, 2, and 3. In each table caption, the data were expressed as “mean ± standard deviation (SD)”; unfortunately, the authors...
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Open AccessPolycomb protein family member CBX7 regulates intrinsic axon growth and regeneration
Neurons in the central nervous system (CNS) lose their intrinsic ability and fail to regenerate, but the underlying mechanisms are largely unknown. Polycomb group (PcG) proteins, which include PRC1 and PRC2 co...
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Open AccessSimulating the ion permeation and ion selection for a eukaryotic voltage-gated sodium channel NaVPaS
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Open AccessCRISPR-Cas12a-assisted nucleic acid detection
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Open Access2-aminopurine suppresses the TGF-β1-induced epithelial–mesenchymal transition and attenuates bleomycin-induced pulmonary fibrosis
The epithelial–mesenchymal transition (EMT) is a multifunctional cell process involved in the pathogenesis of numerous conditions, including fibrosis and cancer. Idiopathic pulmonary fibrosis (IPF) is a progre...
