193 Result(s)

Article

YAP nuclear translocation induced by HIF-1α prevents DNA damage under hypoxic conditions

Maladaptive repair of acute kidney injury (AKI) is associated with a high risk of develo** chronic kidney disease deemed irremediable even in present days. When AKI arises from ischemia-reperfusion injury, h...

Heng-Ai Chang, Rui-Zhi Ou Yang, **g-Ming Su, Thi My Hang Nguyen… in Cell Death Discovery (2023)

Article

MafB regulates NLRP3 inflammasome activation by sustaining p62 expression in macrophages

Activation of the NLRP3 inflammasome is a two-step process: the priming and the activating. The priming step involves the induction of NLRP3 and pro-IL-1β, while the activating step leads to the full inflammas...

Huachun Cui, Sami Banerjee, Na **e, Tapan Dey, Rui-Ming Liu… in Communications Biology (2023)

Article

Author Correction: Genomic insights into biased allele loss and increased gene numbers after genome duplication in autotetraploid Cyclocarya paliurus

Rui-Min Yu, Ning Zhang, Bo-Wen Zhang, Yu Liang, **ao-Xu Pang, Lei Cao… in BMC Biology (2023)

Article

Structural and functional analyses of Burkholderia pseudomallei BPSL1038 reveal a Cas-2/VapD nuclease sub-family

Burkholderia pseudomallei is a highly versatile pathogen with ~25% of its genome annotated to encode hypothetical proteins. One such hypothetical protein, BPSL1038, is conserved across seven bacterial genera and ...

Sofiyah Shaibullah, Nurshahirah Shuhaimi, De-Sheng Ker… in Communications Biology (2023)

Article

Genomic insights into biased allele loss and increased gene numbers after genome duplication in autotetraploid Cyclocarya paliurus

Autopolyploidy is a valuable model for studying whole-genome duplication (WGD) without hybridization, yet little is known about the genomic structural and functional changes that occur in autopolyploids after ...

Rui-Min Yu, Ning Zhang, Bo-Wen Zhang, Yu Liang, **ao-Xu Pang, Lei Cao… in BMC Biology (2023)

Article

Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions

Protein-biomolecule interactions play pivotal roles in almost all biological processes. For a biomolecule of interest, the identification of the interacting protein(s) is essential. For this need, although man...

He-Wei Jiang, Hong Chen, Yun-**ao Zheng, Xue-Ning Wang… in Science China Life Sciences (2023)

Article

Stem cell-derived intestinal organoids: a novel modality for IBD

The organoids represent one of the greatest revolutions in the biomedical field in the past decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly similar to that of the tissu...

Cheng-mei Tian, Mei-feng Yang, Hao-ming Xu, Min-zheng Zhu… in Cell Death Discovery (2023)

Article

TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m⁷G methylation of ATF5 mRNA

The mitochondrial transmembrane (TMEM) protein family has several essential physiological functions. However, its roles in cardiomyocyte proliferation and cardiac regeneration remain unclear. Here, we detected...

**n-Zhe Chen, **n-Min Li, Shi-Jun Xu, Shen Hu, Tao Wang… in Cell Death & Differentiation (2023)

Article

RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury

Acute lung injury (ALI) is characterised by severe pulmonary inflammation, alveolar-capillary barrier disruption, and pulmonary oedema. Therefore, establishing effective therapeutic targets for ALI prevention ...

Pei-Yao Liu, Chih-Yuan Chen, Yu-Lung Lin, Chien-Ming Lin… in Cell Death & Disease (2023)

Article

Activation of HIF-1α C-terminal transactivation domain protects against hypoxia-induced kidney injury through hexokinase 2-mediated mitophagy

The transcription factor hypoxia-inducible factor-1α (HIF-1α), as a master regulator of adaptive responses to hypoxia, possesses two transcriptional activation domains [TAD, N-terminal (NTAD), and C-terminal (...

Zuo-Lin Li, Lin Ding, Rui-**a Ma, Yue Zhang, Yi-Lin Zhang… in Cell Death & Disease (2023)

Article

Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration

Human mitochondrial NAD(P)⁺-dependent malic enzyme (ME2) is well-known for its role in cell metabolism, which may be involved in cancer or epilepsy. We present potent ME2 inhibitors based on cyro-EM structures th...

Ju-Yi Hsieh, Kun-Chi Chen, Chun-Hsiung Wang, Guang-Yaw Liu… in Communications Biology (2023)

Article

Macrophages mediate psoriasis via Mincle-dependent mechanism in mice

Psoriasis is currently considered to be an immune and inflammatory disease characterized by massive immune cells infiltration including macrophages. It has been reported that macrophage-inducible C-type lectin...

Rui-zhi Tan, **a Zhong, Rang-yue Han, Ke-huan **e, Jian Jia… in Cell Death Discovery (2023)

Article

Insight into the evolutionary and domesticated history of the most widely cultivated mushroom Agaricus bisporus via mitogenome sequences of 361 global strains

Agaricus bisporus is the most widely cultivated edible mushroom in the world with a only around three hundred years known history of cultivation. Therefore, it represents an ideal organism not only to investigate...

Ming-Zhe Zhang, Jian-** Xu, Philippe Callac, Mei-Yuan Chen, Qi Wu… in BMC Genomics (2023)

Article

Author Correction: A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy

Li-Heng Che, **g-Wen Liu, Jian-** Huo, Rong Luo, Rui-Min Xu, Cai He… in Cell Discovery (2023)

Article

CD36⁺ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor

Hepatocellular carcinoma (HCC) is an immunotherapy-resistant malignancy characterized by high cellular heterogeneity. The diversity of cell types and the interplay between tumor and non-tumor cells remain to b...

Gui-Qi Zhu, Zheng Tang, Run Huang, Wei-Feng Qu, Yuan Fang, Rui Yang… in Cell Discovery (2023)