87 Result(s)
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Inhibition of drug-metabolizing enzymes by **gyin granules: implications of herb–drug interactions in antiviral therapy
**gyin granules, a marketed antiviral herbal medicine, have been recommended for treating H1N1 influenza A virus infection and Coronavirus disease 2019 (COVID-19) in China. To fight viral diseases in a more e...
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A global phosphoproteomics analysis of adult Fasciola gigantica by LC–MS/MS
Protein phosphorylation plays key roles in a variety of essential cellular processes. Fasciola gigantica is a tropical liver fluke causing hepatobiliary disease fascioliasis, leading to human health threats and h...
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Open AccessCepharanthine sensitizes human triple negative breast cancer cells to chemotherapeutic agent epirubicin via inducing cofilin oxidation-mediated mitochondrial fission and apoptosis
Inhibition of autophagy has been accepted as a promising therapeutic strategy in cancer, but its clinical application is hindered by lack of effective and specific autophagy inhibitors. We previously identifie...
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Open AccessCD98-induced CD147 signaling stabilizes the Foxp3 protein to maintain tissue homeostasis
Regulatory T cell (Treg) stability is necessary for the proper control of immune activity and tissue homeostasis. However, it remains unclear whether Treg stability must be continually reinforced or is establi...
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Open AccessMitochondrial proteome of mouse oocytes and cisplatin-induced shifts in protein profile
Mitochondria are essential organelles that provide energy for mammalian cells and participate in multiple functions, such as signal transduction, cellular differentiation, and regulation of apoptosis. Compared...
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Open AccessCorrection to: Biogeographic traits of dimethyl sulfide and dimethylsulfoniopropionate cycling in polar oceans
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Open AccessBerberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation
Accumulating evidence shows that agents targeting gut dysbiosis are effective for improving symptoms of irritable bowel syndrome (IBS). However, the potential mechanisms remain unclear. In this study we invest...
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Open AccessBiogeographic traits of dimethyl sulfide and dimethylsulfoniopropionate cycling in polar oceans
Dimethyl sulfide (DMS) is the dominant volatile organic sulfur in global oceans. The predominant source of oceanic DMS is the cleavage of dimethylsulfoniopropionate (DMSP), which can be produced by marine bact...
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Probiotics protect against RSV infection by modulating the microbiota-alveolar-macrophage axis
Respiratory syncytial virus (RSV) is leading cause of respiratory tract infections in early childhood. Gut microbiota is closely related with the pulmonary antiviral immunity. Recent evidence shows that gut dy...
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Article
6-Gingerol protects against cardiac remodeling by inhibiting the p38 mitogen-activated protein kinase pathway
6-Gingerol, a pungent ingredient of ginger, has been reported to possess anti-inflammatory and antioxidant activities, but the effect of 6-gingerol on pressure overload-induced cardiac remodeling remains incon...
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Pretreatment with chitosan oligosaccharides attenuate experimental severe acute pancreatitis via inhibiting oxidative stress and modulating intestinal homeostasis
Severe acute pancreatitis (SAP) is a severe acute abdominal disease. Recent evidence shows that intestinal homeostasis is essential for the management of acute pancreatitis. Chitosan oligosaccharides (COS) pos...
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Icariside II attenuates cerebral ischemia/reperfusion-induced blood–brain barrier dysfunction in rats via regulating the balance of MMP9/TIMP1
Cerebral ischemia/reperfusion (I/R) results in harmful consequences during ischemic stroke, especially the disruption of the blood–brain barrier (BBB), which leads to severe hemorrhagic transformation through ...
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Elevated plasma phage load as a marker for intestinal permeability in leukemic patients
Microbial translocation (MT) and altered gut microbiota have been described in acute leukemic patients and contribute to immune activation and inflammation. However, phage translocation has not been investigat...
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Open AccessBradymonabacteria, a novel bacterial predator group with versatile survival strategies in saline environments
Bacterial predation is an important selective force in microbial community structure and dynamics. However, only a limited number of predatory bacteria have been reported, and their predatory strategies and ev...
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Open AccessCorrection to: Structure and function of the Arctic and Antarctic marine microbiota as revealed by metagenomics
An amendment to this paper has been published and can be accessed via the original article.
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Mechanisms and pharmacokinetic/pharmacodynamic profiles underlying the low nephrotoxicity and ototoxicity of etimicin
Etimicin (ETM), a fourth-generation aminoglycosides (AGs), is now widely clinically used in China due to its high efficacy and low toxicity. However, the mechanisms underlying its low nephrotoxicity and ototox...
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Open AccessStructure and function of the Arctic and Antarctic marine microbiota as revealed by metagenomics
The Arctic and Antarctic are the two most geographically distant bioregions on earth. Recent sampling efforts and following metagenomics have shed light on the global ocean microbial diversity and function, ye...
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Author Correction: Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of mice
During re-read of our previously article Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of micepublished in Acta Pharmacologica Sinica, we were regretted to point ou...
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Residual platelet reactivity is preferred over platelet inhibition rate in monitoring antiplatelet efficacy: insights using thrombelastography
Although thrombelastography (TEG) has been widely implemented in the clinical setting of endovascular intervention, consensus on the optimal parameter for defining high ischemic risk patients is lacking due to...
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Somatic and germline mutations in the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells
PARK2, which encodes Parkin, is a disease-causing gene for both neurodegenerative disorders and cancer. Parkin can function as a neuroprotector that plays a crucial role in the regulation of mitophagy, and germli...
