Resistance to Proteasome Inhibitors in Cancer
Molecular Mechanisms and Strategies to Overcome Resistance
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Proteasome inhibitors induce AMPK activation via CaMKKβ in human breast cancer cells
The purpose of present study is to examine the mechanism of the 5′-AMP-activated protein kinase (AMPK) activation induced by proteasome inhibitors. AMPK activation and ubiquitin proteasome system (UPS) inhibit...
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Article
l-Ornithine Schiff base–copper and –cadmium complexes as new proteasome inhibitors and apoptosis inducers in human cancer cells
Ubiquitin–proteasome system (UPS) plays a crucial role in many cellular processes such as cell cycle, proliferation and apoptosis. Aberrant activation of UPS may result in cellular transformation or other alte...
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Article
Gene–environment interactions between JAZF1 and occupational and household lead exposure in prostate cancer among African American men
A single nucleotide polymorphism, rs10486567, in JAZF1 has consistently been associated with increased risk of prostate cancer. The physical interaction of zinc finger proteins, such as JAZF1, with heavy metals m...
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Article
Open AccessA novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases
The successful development of bortezomib-based therapy for treatment of multiple myeloma has established proteasome inhibition as an effective therapeutic strategy and both 20S proteasome peptidases and 19S de...
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Article
Prostate Tissue Metal Levels and Prostate Cancer Recurrence in Smokers
Although smoking is not associated with prostate cancer risk overall, smoking is associated with prostate cancer recurrence and mortality. Increased cadmium (Cd) exposure from smoking may play a role in progre...
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Chapter
Proteasome Inhibitors and Lessons Learned from Their Mechanisms of Action and Resistance in Human Cancer
Selective protein degradation by the ubiquitin–proteasome pathway (UPP) is critical to cellular homeostasis, and dysregulation of the UPP has been associated with human diseases including cancer. Proteasome in...
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Reference Work Entry In depth
Gallium(III) Complexes, Inhibition of Proteasome Activity
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Chapter
Proteasome Inhibition as a Novel Strategy for Cancer Treatment
The proteasome is a multi-subunit protease complex, responsible for the degradation of misfolded, damaged, or short-lived proteins. Indeed, more than 90 % of intracellular proteins are degraded through the ubi...
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Article
1,10-Phenanthroline promotes copper complexes into tumor cells and induces apoptosis by inhibiting the proteasome activity
Indole-3-acetic acid and indole-3-propionic acid, two potent natural plant growth hormones, have attracted attention as promising prodrugs in cancer therapy. Copper is known to be a cofactor essential for tumo...
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Article
Association of Metals and Proteasome Activity in Erythrocytes of Prostate Cancer Patients and Controls
Information is lacking on the effects toxic environmental metals may have on the 26S proteasome. The proteasome is a primary vehicle for selective degradation of damaged proteins in a cell and due to its role ...
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Article
Transcriptional activation of breast cancer-associated gene 2 by estrogen receptor
RNF115, or Breast Cancer-Associated Gene 2 (BCA2), encodes a RING-finger ubiquitin E3 ligase, expression of which was associated with estrogen receptor (ER)-positive status in human breast tumors. Although the...
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Chapter
Nutritional Compounds as Chemopreventive Agents by Proteasome Inhibition
Nutritional phytochemicals, distributed throughout the plant kingdom, possess anticancer activities associated with their consumption. This chapter will focus on the cellular activities of phytochemicals, thei...
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Article
Molecular characterization and phylogenetic analysis of a yak (Bos grunniens) κ-casein cDNA from lactating mammary gland
κ-Casein is one of the major proteins in the milk of mammals. It plays an important role in determining the size and specific function of milk micelles. We have previously identified and characterized a geneti...
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Article
Physiological levels of ATP negatively regulate proteasome function
Intracellular protein degradation by the ubiquitin-proteasome system is ATP dependent, and the optimal ATP concentration to activate proteasome function in vitro is ∼100 μM. Intracellular ATP levels are generally...
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Article
Targeted proteasome inhibition by Velcade induces apoptosis in human mesothelioma and breast cancer cell lines
Thoracic malignancies and human breast cancer (HBC) continue to be aggressive solid tumors that are poor responders to the existing conventional standard chemotherapeutic approaches. Malignant pleural mesothel...
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Article
Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells
We have previously reported that when mixed with copper, 8-hydroxyquinoline (8-OHQ) and its analog clioquinol (CQ) inhibited the proteasomal activity and proliferation in cultured human cancer cells. CQ treatm...
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Chapter and Conference Paper
Abrasion-Resistant Technology and its Prospect for CFB Boilers
In recent years, CFB boilers (CFBB) have been widely used in the commercial power plants due to its environmental benefits, high combustion efficiency, wide coal flexibility, and some other advantages. At the ...
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Article
Fluorocurcumins as Cyclooxygenase-2 Inhibitor: Molecular Docking, Pharmacokinetics and Tissue Distribution in Mice
The purpose of the current study was to assess the effect of newly synthesized Curcumin analogs on COX-2 protein by molecular docking studies and by assessments of the effect of one such analog (CDF) on nuclea...
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Article
New Difluoro Knoevenagel Condensates of Curcumin, Their Schiff Bases and Copper Complexes as Proteasome Inhibitors and Apoptosis Inducers in Cancer Cells
Emerging evidence clearly suggests the potential chemopreventive and anti-tumor activity of a well known “natural agent” curcumin. However, studies have shown that curcumin is not readily bioavailable, and thu...
