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Article
Open AccessThe association between polypharmacy and late life deficits in cognitive, physical and emotional capability: a cohort study
Background Polypharmacy is a growing health concern for older adults and is associated with poorer clinical outcome. Objective This study aim is to investigate the association between polypharmacy and impairment ...
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Article
Open AccessDevelopment of a core outcome set for effectiveness trials aimed at optimising prescribing in older adults in care homes
Prescribing medicines for older adults in care homes is known to be sub-optimal. Whilst trials testing interventions to optimise prescribing in this setting have been published, heterogeneity in outcome report...
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Article
Open AccessPre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis
Pre-eclampsia is a pregnancy-specific multisystem disorder and a state of physiological insulin resistance. Our aim was to systematically evaluate and quantify the evidence on the relationship between pre-ecla...
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Article
Open AccessFeasibility of a randomized controlled trial of functional strength training for people between six months and five years after stroke: FeSTivaLS trial
Functional Strength Training (FST) could enhance recovery late after stroke. The aim of this study was to evaluate the feasibility of a subsequent fully powered, randomized controlled trial.
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Article
Open AccessThe use of carer assisted adherence therapy for people with Parkinson's disease and their carers (CAAT-PARK): study protocol for a randomised controlled trial
Pharmacological intervention is essential for managing the symptoms of Parkinson's disease. Adherence to medication regimens however is a major problem. Poor adherence leads to significant motor deterioration ...
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Article
Open AccessA Dep ression Re cognition and T reatment package for families living with Stroke (DepReT-Stroke): study protocol for a randomised controlled trial
Depression occurs in up to 50% of patients after stroke and limits rehabilitation and recovery. Mood disorders are also highly prevalent in carers; their mental health intertwined with the physical and mental ...
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Article
Open AccessEvaluation of stroke services in Anglia stroke clinical network to examine the variation in acute services and stroke outcomes
Stroke is the third leading cause of death in developed countries and the leading cause of long-term disability worldwide. A series of national stroke audits in the UK highlighted the differences in stroke car...
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Article
Open AccessNature or nurture; BMI and blood pressure at 90. Findings from the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST)
Hypertension is a key risk factor for stroke, cardiovascular disease and dementia. Although the link between weight, sodium and hypertension is established in younger people, little is known about their inter-...
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Article
Open AccessDelayed transfer of care from NHS secondary care to primary care in England: its determinants, effect on hospital bed days, prevalence of acute medical conditions and deaths during delay, in older adults aged 65 years and over
The delay in discharge or transfer of care back to the community following an acute admission to the hospital in older adults has long been a recognized challenge in the UK. We examined the determinants and ou...
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Article
Open AccessAccuracy of death certification and hospital record linkage for identification of incident stroke
There is little information on the validity of using record linkage with routinely collected data for case ascertainment of stroke in large population-based studies in the UK. We examined the accuracy of these...
