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Article
Open AccessTarget discovery for T cell therapy: next steps to advance Immunotherapies
Investigators from academia and industry gathered on August 14, 2014, in Boston at the Inaugural ImVacS conference entitled “Target Discovery for T Cell Therapy: Next Step to Advance Immunotherapies”. Novel ta...
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Article
Open AccessToward cell transfer immunotherapy against patient-specific mutations in gastrointestinal cancers
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Open AccessIndividual cultures of melanoma tumor infiltrating lymphocytes possess distinct patterns of reactivity with mutated antigens identified by whole exome sequencing of autologous tumors
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Article
Open AccessMelanoma-associated B cells are distinct from peripheral blood-derived B cells, and may serve as a source of tumor-targeting antibodies
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Article
Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
Identifying tumor-associated T cell epitopes can be laborious. Robbins et al. now report that they used whole-exome sequence data to identify mutated peptides from tumor antigens that are recognized by tumor-infi...
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Article
Recognition of NY-ESO-1+ tumor cells by engineered lymphocytes is enhanced by improved vector design and epigenetic modulation of tumor antigen expression
The therapeutic use of T cell receptor (TCR)-transduced peripheral blood lymphocytes (PBL) targeting tumor-associated antigens is emerging as a promising investigational treatment for patients with cancer. Ini...
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Article
Enforcement Authority and Vegetation Change at Kumbhalgarh Wildlife Sanctuary, Rajasthan, India
Land cover change in protected areas is often associated with human use, especially illicit extraction, but the direction and spatial distribution of such effects and their drivers are poorly understood. We an...
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Tumor Associated Antigens
The results of an extensive series of studies that were first carried out in the early 1990s have revealed that human tumor reactive T cells recognize a diverse array of antigens. These include antigens expres...
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Article
MHC class I and class II presentation of tumor antigen in retrovirally and adenovirally transduced dendritic cells
The unique antigen-presenting capabilities of dendritic cells (DCs) make them an attractive means with which to initiate an antitumor immune response. Using DCs transduced with tumor antigens for immunotherapy...
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Article
A listing of human tumor antigens recognized by T cells
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Article
Evaluation of human carcinoembryonic-antigen (CEA)-transduced and non-transduced murine tumors as potential targets for anti-CEA therapies
The MC-38 C57BL/6 mouse colon adenocarcinoma cell line has been transduced with a retroviral construct containing cDNA encoding the human carcinoembryonic antigen (CEA) gene [Robbins PF, Kantor JA, Salgaller M...
