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Open AccessNono deficiency impedes the proliferation and adhesion of H9c2 cardiomyocytes through Pi3k/Akt signaling pathway
Congenital heart disease (CHD) is the most common type of birth defect and the main noninfectious cause of death during the neonatal stage. The non-POU domain containing, octamer-binding gene, NONO, performs a va...
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Open AccessPan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment
Cancer-associated fibroblasts (CAFs) are the predominant components of the tumor microenvironment (TME) and influence cancer hallmarks, but without systematic investigation on their ubiquitous characteristics ...
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Article
Open AccessMissed Monteggia fractures in children treated by open reduction of the radial head and corrective osteotomy of the ulna
Missed Monteggia fractures in children may cause pain, deformity, decreased range of motion, neurological symptoms, and late arthritis of the elbow. Numerous surgical techniques have been advocated to reconstr...
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Open AccessSuperstretchable, yet stiff, fatigue-resistant ligament-like elastomers
Ligaments are flexible and stiff tissues around joints to support body movements, showing superior toughness and fatigue-resistance. Such a combination of mechanical properties is rarely seen in synthetic elas...
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Open AccessEffectiveness of Lymphatic Contrast Enhanced Ultrasound in the diagnosis of Cervical Lymph node metastasis from papillary thyroid carcinoma
Cervical lymph node metastasis (CLNM) is common in patients with papillary thyroid carcinoma (PTC), which is responsible for tumor staging and surgical strategy. The accurate preoperative identification of CLN...
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Open AccessLow chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk
Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear. Herein, in our retros...
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Open AccessVisible-light photoredox-catalyzed umpolung carboxylation of carbonyl compounds with CO2
Photoredox-mediated umpolung strategy provides an alternative pattern for functionalization of carbonyl compounds. However, general approaches towards carboxylation of carbonyl compounds with CO2 remain scarce. H...
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Open AccessCompeting risk model to determine the prognostic factors and treatment strategies for elderly patients with glioblastoma
The prognostic factors and optimal treatment for the elderly patient with glioblastoma (GBM) were poorly understood. This study extracted 4975 elderly patients (≥ 65 years old) with histologically confirmed GB...
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Open AccessAn immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer
Immunosuppressive molecules are extremely valuable prognostic biomarkers across different cancer types. However, the diversity of different immunosuppressive molecules makes it very difficult to accurately pre...
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Open AccessReductive dearomative arylcarboxylation of indoles with CO2 via visible-light photoredox catalysis
Catalytic reductive coupling of two electrophiles and one unsaturated bond represents an economic and efficient way to construct complex skeletons, which is dominated by transition-metal catalysis via two elec...
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Article
Atomic imaging of the edge structure and growth of a two-dimensional hexagonal ice
The formation and growth of water-ice layers on surfaces and of low-dimensional ice under confinement are frequent occurrences1–4. This is exemplified by the extensive reporting of two-dimensional (2D) ice on met...
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Open AccessTissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant
A noncoding polymorphism (rs78378222) in TP53, carried by scores of millions of people, was previously associated with moderate risk of brain tumors and other neoplasms. We find a positive association between thi...
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Open AccessDNA methylation of antisense noncoding RNA in the INK locus (ANRIL) is associated with coronary artery disease in a Chinese population
To explore the association between methylation of antisense non-coding RNA in the INK4 locus (ANRIL) and coronary artery disease (CAD) development. Methylation levels of ANRIL in 100 subjects with CAD and 100 ...
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Open AccessLatent Infection of Valsa mali in the Seeds, Seedlings and Twigs of Crabapple and Apple Trees is a Potential Inoculum Source of Valsa Canker
A real-time quantitative PCR assay using a species-specific primer pair was developed to rapidly and accurately quantify Valsa mali, the causative pathogen of apple Valsa canker (AVC), in crabapple seeds, crabapp...
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Open AccessGmSYP24, a putative syntaxin gene, confers osmotic/drought, salt stress tolerances and ABA signal pathway
As major environment factors, drought or high salinity affect crop growth, development and yield. Transgenic approach is an effective way to improve abiotic stress tolerance of crops. In this study, we compara...
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Open AccessThe genetic Creutzfeldt-Jakob disease with E200K mutation: analysis of clinical, genetic and laboratory features of 30 Chinese patients
Genetic Creutzfeldt-Jakob disease (gCJD) with E200K mutation is one of the common subtypes of human genetic prion diseases worldwide. In this study, we systematically analyzed 30 Chinese E200K gCJD cases for t...
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Publisher Correction: The effect of hydration number on the interfacial transport of sodium ions
In this Letter, the links to Supplementary Videos 5, 7, 9 and 10 were incorrect, and there were some formatting errors in the Supplementary Video legends. These errors have been corrected online.
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Open AccessHub-organized parallel circuits of central circadian pacemaker neurons for visual photoentrainment in Drosophila
Circadian rhythms are orchestrated by a master clock that emerges from a network of circadian pacemaker neurons. The master clock is synchronized to external light/dark cycles through photoentrainment, but the...
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Open AccessEvolution of thiolate-stabilized Ag nanoclusters from Ag-thiolate cluster intermediates
The synthesis of atomically precise thiolate-stabilized silver (Ag) nanoclusters is the subject of intense research interest, yet the formation mechanism of such nanoclusters remains obscure. Here, electrospra...
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The effect of hydration number on the interfacial transport of sodium ions
Ion hydration and transport at interfaces are relevant to a wide range of applied fields and natural processes1–5. Interfacial effects are particularly profound in confined geometries such as nanometre-sized chan...