432 Result(s)

Article

Nanoparticle delivery of si-Notch1 modulates metabolic reprogramming to affect 5-FU resistance and cell pyroptosis in colorectal cancer

Nanocarrier delivery of small interfering RNAs (siRNAs) to silence cancer-associated genes is a promising method for cancer treatment. Here, we explored the role and mechanisms of PLAG NPs-delivered si-Notch1 ...

Dan-dan Li, Jia-cheng **, Xuan-wen Liu, Shu-yang Liu, Fu-jian Ji… in Cancer Nanotechnology (2024)

Article

Clinicopathological factors predict residual lymph node metastasis in locally advanced rectal cancer with ypT0-2 after neoadjuvant chemoradiotherapy

Residual lymph node metastases (RLNM) remained a great concern in the implementation of organ-preserving strategies and led to poor prognosis in locally advanced rectal cancer (LARC). In this study, we aimed t...

Yujun Cui, Maxiaowei Song, Jian Tie… in Journal of Cancer Research and Clinical On… (2024)

Article

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

A radiomics signature derived from CT imaging to predict MSI status and immunotherapy outcomes in gastric cancer: a multi-cohort study

Accurate microsatellite instability (MSI) testing is essential for identifying gastric cancer (GC) patients eligible for immunotherapy. We aimed to develop and validate a CT-based radiomics signature to predic...

Peng-chao Zhan, Shuo Yang, **ng Liu, Yu-yuan Zhang, Rui Wang, Jia-xing Wang… in BMC Cancer (2024)

Article

Targeting TYK2 alleviates Rab27A-induced malignant progression of non-small cell lung cancer via disrupting IFNα-TYK2-STAT-HSPA5 axis

Rab27A is a small GTPase-mediating exosome secretion, which participates in tumorigenesis of multiple cancer types. Understanding the biological role of Rab27A in non-small cell lung cancer (NSCLC) is of great...

Yuanyuan Zeng, Jian Zhao, Zhengyan Wu, Yongkang Huang, Anqi Wang… in npj Precision Oncology (2024)

Article

C/EBPα-p30 confers AML cell susceptibility to the terminal unfolded protein response and resistance to Venetoclax by activating DDIT3 transcription

Acute myeloid leukemia (AML) with biallelic (CEBPA^bi) as well as single mutations located in the bZIP region is associated with a favorable prognosis, but the underlying mechanisms are still unclear. Here, we pro...

Mengbao Du, Mowang Wang, Meng Liu, Shan Fu… in Journal of Experimental & Clinical Cancer … (2024)

Article

Influential upregulation of KCNE4: Propelling cancer associated fibroblasts-driven colorectal cancer progression

Colorectal cancer (CRC) is a malignancy of remarkable heterogeneity and heightened morbidity. Cancer associated fibroblasts (CAFs) are abundant in CRC tissues and are essential for CRC growth. Here, we aimed t...

Zizhen Zhang, Shengde Liu, Zhenghang Wang, Shuo Wang… in Cancer Cell International (2024)

Article

Tet methylcytosine dioxygenase 2 (TET2) deficiency elicits EGFR-TKI (tyrosine kinase inhibitors) resistance in non-small cell lung cancer

Despite epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) have shown remarkable efficacy in patients with EGFR-mutant non-small cell lung cancer (NSCLC), acquired resistance inevitably deve...

Jian Zhang, Kejia Zhao, Wen**g Zhou, Ran Kang… in Signal Transduction and Targeted Therapy (2024)

Article

Genetic fusion of CCL11 to antigens enhances antigenicity in nucleic acid vaccines and eradicates tumor mass through optimizing T-cell response

Nucleic acid vaccines have shown promising potency and efficacy for cancer treatment with robust and specific T-cell responses. Improving the immunogenicity of delivered antigens helps to extend therapeutic ef...

Hailong Qi, Zhongjie Sun, Tianle Gao, Yanling Yao, Yu Wang, Weiwei Li… in Molecular Cancer (2024)

Article

Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

Respiratory disease caused by coronavirus infection remains a global health crisis. Although several SARS-CoV-2-specific vaccines and direct-acting antivirals are available, their efficacy on emerging coronavi...

**ong **e, Qiaoshuai Lan, **yi Zhao… in Signal Transduction and Targeted Therapy (2024)

Article

Evaluating the comprehensive diagnosis efficiency of lung cancer, including measurement of SHOX2 and RASSF1A gene methylation

Methylation of the promoters of SHOX2 and RASSF1A (LungMe®) exhibits promise as a potential molecular biomarker for diagnosing lung cancer. This study sought to assess the aberrant methylation of SHOX2 and RAS...

Jian Liu, Tingting Bian, Bin She, Lei Liu, Hui Sun, Qing Zhang, Jun Zhu… in BMC Cancer (2024)

Article

Treatment for locally resectable stage IIIC1r cervical cancer: surgery or chemoradiotherapy?

The aim of this study was to compare the therapeutic value and treatment-related complications of radical hysterectomy with those of concurrent chemoradiotherapy (CCRT) for locally resectable (T1a2–T2a1) stage...

Mei-ling Zhong, Yin-chuan Liu, Jian-tong Yang, Ya-nan Wang, Mei-hong Ao… in BMC Cancer (2024)

Article

From glioma gloom to immune bloom: unveiling novel immunotherapeutic paradigms-a review

In tumor therapeutics, the transition from conventional cytotoxic drugs to targeted molecular therapies, such as those targeting receptor tyrosine kinases, has been pivotal. Despite this progress, the clinical...

Moksada Regmi, Yingjie Wang, Weihai Liu… in Journal of Experimental & Clinical Cancer … (2024)

Article

Author Correction: Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial

Shu-Qiang Yuan, Run-Cong Nie, Ying **, Cheng-Cai Liang, Yuan-Fang Li… in Nature Medicine (2024)

Article

Prediction of positive pulmonary nodules based on machine learning algorithm combined with central carbon metabolism data

Lung cancer causes a huge disease burden, and early detection of positive pulmonary nodules (PPNs) as an early sign of lung cancer is extremely important for effective intervention. It is necessary to develop ...

Jian-jun Liu, Wen-bin Shen, Qi-rong Qin… in Journal of Cancer Research and Clinical On… (2024)

Article

Spatial and temporal heterogeneity of tumor immune microenvironment between primary tumor and brain metastases in NSCLC

Brain metastasis is a common outcome in non-small cell lung cancer, and despite aggressive treatment, its clinical outcome is still frustrating. In recent years, immunotherapy has been develo** rapidly, howe...

**-Sheng Liu, Yu-**ang Cai, Yong-Ze He, Jian Xu, Su-Fang Tian, Zhi-Qiang Li in BMC Cancer (2024)

Article

The dopamine receptor D1 inhibitor, SKF83566, suppresses GBM stemness and invasion through the DRD1-c-Myc-UHRF1 interactions

Extensive local invasion of glioblastoma (GBM) cells within the central nervous system (CNS) is one factor that severely limits current treatments. The aim of this study was to uncover genes involved in the in...

Zhiyi Xue, Yan Zhang, Ruiqi Zhao… in Journal of Experimental & Clinical Cancer … (2024)

Article

Hypofractionated radiotherapy for refractory or relapsed aggressive B-cell lymphoma in the rituximab era

Radiotherapy (RT) is an effective and available local treatment for patients with refractory or relapsed (R/R) aggressive B-cell lymphomas. However, the value of hypofractionated RT in this setting has not bee...

Cheng Huang, Tian-Lan Tang, Yan-Yan Qiu, Yu-** Lin, Si-Lin Chen… in BMC Cancer (2024)

Article

GLUD1 inhibits hepatocellular carcinoma progression via ROS-mediated p38/JNK MAPK pathway activation and mitochondrial apoptosis

Glutamate dehydrogenase 1 (GLUD1) is an important enzyme in glutamine metabolism. Previously, we found GLUD1 was down-regulated in tumor tissues of hepatocellular carcinoma (HCC) patients by proteomics study. ...

Qianwei Zhao, Mengdan Yu, **xia Li, Yaoyu Guo, Zexuan Wang, Kefei Hu… in Discover Oncology (2024)

Article

Prognostic value of baseline neutrophil/lymphocyte ratio in HER2-positive metastatic breast cancer: exploratory analysis of data from the CLEOPATRA trial

This study aimed to evaluate the prognostic role of the baseline neutrophil/lymphocyte ratio (NLR) in HER2-positive metastatic breast cancer (MBC) patients treated with trastuzumab/pertuzumab.

Nianhua Ding, Jian Pang, Xuan Liu, **ongbin He, Wei Zhou… in Breast Cancer Research (2024)