139 Result(s)
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Open AccessA randomized clinical trial for comparing the efficacy of desensitizing toothpastes on the relief of dentin hypersensitivity
The 4-week double-blind clinical trial to manage dentin hypersensitivity (DH) using different desensitizing toothpastes was conducted. 53 participants with DH were enrolled in this trial. The participants were...
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Open AccessMolecular mechanisms of coronary artery disease risk at the PDGFD locus
Genome wide association studies for coronary artery disease (CAD) have identified a risk locus at 11q22.3. Here, we verify with mechanistic studies that rs2019090 and PDGFD represent the functional variant and ge...
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Open AccessSafety and effectiveness of anticoagulation with non-vitamin K antagonist oral anticoagulants and warfarin in patients on tuberculosis treatment
Anti-tuberculosis treatment can cause significant drug-drug interaction and interfere with effective anticoagulation. However, there is a lack of evidence and conflicting data on the optimal oral anticoagulati...
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Open AccessLive probiotic bacteria administered in a pathomimetic Leaky Gut Chip ameliorate impaired epithelial barrier and mucosal inflammation
Here, we report a pathomimetic Leaky Gut Chip that recapitulates increased epithelial permeability and intestinal inflammation to assess probiotic intervention as live biotherapeutics. We leveraged a mechanody...
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Open AccessDifferential diagnosis of common etiologies of left ventricular hypertrophy using a hybrid CNN-LSTM model
Differential diagnosis of left ventricular hypertrophy (LVH) is often obscure on echocardiography and requires numerous additional tests. We aimed to develop a deep learning algorithm to aid in the differentia...
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Open AccessG protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis
Human genetics has been instrumental in identification of genetic variants linked to type 2 diabetes. Recently a rare, putative loss-of-function mutation in the orphan G-protein coupled receptor 151 (GPR151) was ...
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Open AccessCHIP ameliorates neuronal damage in H2O2-induced oxidative stress in HT22 cells and gerbil ischemia
Carboxyl terminus of Hsc70-interacting protein (CHIP) is highly conserved and is linked to the connection between molecular chaperones and proteasomes to degrade chaperone-bound proteins. In this study, we syn...
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Open AccessAuthor Correction: Frozen section utilization to omit systematic biopsy in diagnosing high risk prostate cancer
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Open AccessCholecystectomy reduces the risk of myocardial and cerebral infarction in patients with gallstone-related infection
We compared the risk of myocardial infarction (MI) or cerebral infarction (CI) in patients with or without-gallstone-related infection (GSI) and change in the risk following cholecystectomy. GSI (n = 84,467) a...
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Open AccessBell-Evans model and steered molecular dynamics in uncovering the dissociation kinetics of ligands targeting G-protein-coupled receptors
Recently, academic and industrial scientific communities involved in kinetics-based drug development have become immensely interested in predicting the drug target residence time. Screening drug candidates in ...
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Open AccessAugmented risk of ischemic stroke in hypertrophic cardiomyopathy patients without documented atrial fibrillation
Although atrial fibrillation (AF) is a well-established risk factor for ischemic stroke (IS) in hypertrophic cardiomyopathy (HCM), the risk of IS in HCM patients without documented AF is less recognized. This ...
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Open AccessFrozen section utilization to omit systematic biopsy in diagnosing high risk prostate cancer
The current guidelines for targeted prostate biopsy recommend an additional systematic biopsy regardless of clinical risk assessment. To evaluate frozen section biopsy utilization in targeted prostate biopsy ...
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Open AccessLimbal epithelial stem cell sheets from young donors have better regenerative potential
To investigate the stemness of limbal epithelial stem cell sheets in relation to the donor’s age. Human limbal explants from cadaveric donors were set on human amniotic membrane scaffolds with the xeno-free me...
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Open AccessSpatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2hi macrophages in infarcted hearts
Heart failure (HF) is a frequent consequence of myocardial infarction (MI). Identification of the precise, time-dependent composition of inflammatory cells may provide clues for the establishment of new biomar...
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Open AccessClassification of severe aortic stenosis and outcomes after aortic valve replacement
Aortic valve calcium scoring by cardiac computed tomographic (CT) has been recommended as an alternative to classify the AS (aortic stenosis) severity, but it is unclear that whether CT findings would have add...
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Open AccessDevelopment of computational design for reliable prediction of dielectric strengths of perfluorocarbon compounds
The development of robust computational protocols capable of accurately predicting the dielectric strengths of eco-friendly insulating gas candidates is crucial; however, it lacks relevant efforts significantl...
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Open AccessComparison of mortality and cause of death between adults with and without hypertrophic cardiomyopathy
Insufficient evidence is available comparing mortality and cause of death between general hypertrophic cardiomyopathy (HCM) and general non-HCM populations. We aimed to investigate how causes of death and mort...
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Open AccessMelatonin reduces the endoplasmic reticulum stress and polyubiquitinated protein accumulation induced by repeated anesthesia exposure in Caenorhabditis elegans
Endoplasmic reticulum (ER) stress has been linked to anesthesia-induced neurotoxicity, but melatonin seems to play a protective role against ER stress. Synchronized Caenorhabditis elegans were exposed to isoflura...
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Article
Open AccessLC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy
LC3/ATG8 has long been appreciated to play a central role in autophagy, by which a variety of cytoplasmic materials are delivered to lysosomes and eventually degraded. However, information on the molecular fun...
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Open AccessEmergency department utilization in patients with hypertrophic cardiomyopathy: a nationwide population-based study
Despite the increasing burden of hypertrophic cardiomyopathy (HCM) on healthcare resources, data on emergency department (ED) utilization in HCM are lacking. This nationwide population-based study extracted 14...
