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Article
Open AccessS6K1 amplification confers innate resistance to CDK4/6 inhibitors through activating c-Myc pathway in patients with estrogen receptor-positive breast cancer
CDK4/6 inhibitors combined with endocrine therapy has become the preferred treatment approach for patients with estrogen receptor-positive metastatic breast cancer. However, the predictive biomarkers and mecha...
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Article
Open AccessClinical application of radiotherapy in patients with oligometastatic ovarian cancer: a sharp tool to prolong the interval of systemic treatment
With the advances of radiation technology, treatment of oligometastatic disease, with limited metastatic burden, have more chances to achieve long-term local control. Here we aim to evaluate the efficacy and s...
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Article
Life-cycle failure probability analysis of deteriorated RC bridges under multiple hazards of earthquakes and strong winds
Engineering structures may be exposed to one or more extreme hazards during their life-cycles. Current structural design specifications usually treat multiple hazards separately in designing structures and the...
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Article
Fiber-microsphere Binary Structured Composite Fibrous Membranes for Waterproof and Breathable Applications
Membranes with the functions of waterproofness and breathability are of great interest due to their huge scientific and commercial value in many practical applications. However, designing such membranes with a...
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Article
Cocrystal engineering: Tuning the charge transfer excitons for highly sensitive luminescent switching materials under multiple stimuli
This paper presents a multi-stimuli responsive cocrystal system with luminescent properties that can be dynamically controlled and demonstrates the responsive mechanism of cocrystals under multiple stimuli (ac...
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Article
Advanced single-cell pooled CRISPR screening identifies C19orf53 required for cell proliferation based on mTORC1 regulators
Multiplexed single-cell CRISPR screening has accelerated the systematic dissection of biological discoveries; however, the efficiency of CRISPR-based gene knockout has inherent limitations. Here, we present Do...
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Chapter and Conference Paper
Data Enhancement Method Based on Generative Adversarial Network for Small Transmission Line Detection
Unmanned aerial vehicle (UAV) patrol inspection is an important means of transmission line detection. However, during UAV patrol, due to the UAV or the bad weather, there may be droplets on the camera lens, wh...
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Article
Open AccessClinicopathological characteristics and survival outcomes in patients with synchronous lung metastases upon initial metastatic breast cancer diagnosis in Han population
We investigated the clinicopathological characteristics and survival of breast cancer lung metastases (BCLM) patients at initial diagnosis of metastatic breast cancer (MBC) in the Han population.
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Article
Open AccessCarboplatin versus cisplatin in combination with etoposide in the first-line treatment of small cell lung cancer: a pooled analysis
Extensive-stage small cell lung cancer (ES-SCLC) is an aggressive disease with poor survival, and platinum-etoposide chemotherapy is indicated as the mainstay of treatment. In this study, we compared the effic...
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Article
Open AccessRisk of develo** second malignant neoplasms in patients with neuroblastoma: a population study of the US SEER database
Neuroblastoma is a common extracranial malignant tumor in children. Its main treatment modality is a combination of chemotherapy, radiotherapy, and surgery. Given the advances in chemotherapy regimens and the ...
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Article
Pharmaceutical care program for ischemic stroke patients: a randomized controlled trial
Background Effective secondary prevention is essential for reducing stroke recurrence. Objective This parallel randomized-controlled study aimed to evaluate the impact of a pharmaceutical care program on risk fac...
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Article
Open AccessSubwavelength silicon photonics for on-chip mode-manipulation
On-chip mode-manipulation is one of the most important physical fundamentals for many photonic integrated devices and circuits. In the past years, great progresses have been achieved on subwavelength silicon p...
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Article
Open AccessThe molecular tumor burden index as a response evaluation criterion in breast cancer
Circulating tumor DNA (ctDNA) is a potential biomarker of prognosis and therapeutic response. We conducted this study to explore the role of the molecular tumor burden index (mTBI) in ctDNA as a therapeutic re...
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Article
A Visually Observable Copper Ion Adsorption Membrane by Electrospinning Combined with Copper Ion Probe
Heavy metal copper ion pollution has enormously threatened ecosystem and public health. So, materials for detecting and adsorbing copper ions (Cu2+) still remains challenging. Electrospinning nanomaterials have g...
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Article
Relationship between H2O2 accumulation and NO synthesis during osmotic stress: promoted somatic embryogenesis of Fraxinus mandshurica
Osmotic stress promotes somatic embryogenesis of Fraxinus mandshurica, which leads to accumulation of reactive oxygen species (ROS). The single pieces of cotyledons of F. mandshurica were used as explants to indu...
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Article
Stroke prediction from electrocardiograms by deep neural network
The brain is an energy-consuming organ that heavily relies on the heart for energy supply. Heart abnormalities detected by electrocardiogram (ECG) might provide diagnostic indicators for brain dysfunctions suc...
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Article
Progress in systemic therapy for triple-negative breast cancer
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with a heterogeneous genetic profile. Chemotherapy exhibits substantial activity in a small subset of these patients. Drug r...
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Article
Seismic response of large-span spatial structures under multi-support and multidimensional excitations including rotational components
To achieve rational and precise seismic response predictions of large span spatial structures (LSSSs), the inherent non-uniformity and multidimensionality characteristics of earthquake ground motions should be...
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Article
Research progress of rubrene as an excellent multifunctional organic semiconductor
Rubrene, a superstar in organic semiconductors, has achieved unprecedented achievements in the application of electronic devices, and research based on its various photoelectric properties is still in progress...
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Article
Oscillating shear stress mediates mesenchymal transdifferentiation of EPCs by the Kir2.1 channel
Although endothelial progenitor cells (EPCs) are considered to be an essential source of vascular endothelial repair, their bidirectional differentiation determines that they play a double-edged role in the re...
