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Open AccessSMRT sequencing revealed to be an effective method for ADTKD-MUC1 diagnosis through follow-up analysis of a Chinese family
We reported a large Chinese family diagnosed with autosomal dominant tubulointerstitial kidney disease caused by MUC1 mutation (ADTKD-MUC1). Cytosine duplication within a string of 7 cytosines in the variable-num...
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Article
Open Access3D-printed model-guided endoscopic evacuation for basal ganglia hemorrhage
The purpose of this study was to investigate the effectiveness and practicality of 3D-printed model-guided endoscopic surgery for the treatment of basal ganglia hemorrhage. The authors retrospectively analyzed...
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Open AccessCare Practices, Morbidity and Mortality of Preterm Neonates in China, 2013–2014: a Retrospective study
This retrospective cohort study aimed to investigate the prevalence, morbidity, mortality and the maternal/neonatal care of preterm neonates and the perinatal risk factors for mortality. We included data on 13...
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Open AccessBTLA suppress acute rejection via regulating TCR downstream signals and cytokines production in kidney transplantation and prolonged allografts survival
Acute rejection is a major risk for renal transplant failure. During this adverse process, activated T cells are considered the main effectors. Recently, B and T lymphocyte attenuator (BTLA), a member of the C...
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Article
Open AccessThe SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression
The interactions between tumor cells with their microenvironments, including hypoxia, acidosis and immune cells, lead to the tumor heterogeneity which promotes tumor progression. Here, we show that SIAH2-NRF1 ...
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Open AccessContributions of modern Gobi Desert to the Badain Jaran Desert and the Chinese Loess Plateau
It is well known that the Gobi Desert is the dominant source area of the Badain Jaran Desert (BJD) and the Chinese Loess Plateau (CLP). However, due to the absence of quantitative analyses, there are nearly no...
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Article
Open AccessThe dynamic transcriptome and metabolomics profiling in Verticillium dahliae inoculated Arabidopsis thaliana
Verticillium wilt caused by the soil-borne fungus Verticillium dahliae is a common, devastating plant vascular disease notorious for causing economic losses. Despite considerable research on plant resistance gene...
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Open AccessAuthor Correction: An intercross population study reveals genes associated with body size and plumage color in ducks
In the original version of this Article, there was an error in the legend for Figure 2, whereby the descriptions of panels a, b and c were presented in a different order to the corresponding figure panels. The...
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Open AccessAn intercross population study reveals genes associated with body size and plumage color in ducks
Comparative population genomics offers an opportunity to discover the signatures of artificial selection during animal domestication, however, their function cannot be directly revealed. We discover the select...
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Article
Open AccessaPKCζ-dependent Repression of Yap is Necessary for Functional Restoration of Irradiated Salivary Glands with IGF-1
Xerostomia and salivary hypofunction often result as a consequence of radiation therapy for head and neck cancers, which are diagnosed in roughly 60,000 individuals every year in the U.S. Due to the lack of ef...
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Open AccessPublisher Correction: Role of outer surface probes for regulating ion gating of nanochannels
The original version of this Article contained an error in Fig. 3. The scale bars in Figs 3c and 3d were incorrectly labelled as 50 μA. In the correct version, the scale bars are labelled as 0.5 μA. This has n...
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Open AccessAssociation of S100B polymorphisms and serum S100B with risk of ischemic stroke in a Chinese population
The levels of serum S100B were elevated in patients with ischemic stroke (IS), which may be a novel biomarker for diagnosing IS. The aim of this study was to investigate the association of S100B polymorphisms and...
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Article
Open AccessBiochemical and genetic characterization of a novel metallo-β-lactamase from marine bacterium Erythrobacter litoralis HTCC 2594
Metallo-β-lactamases (MBLs) are a group of enzymes that can inactivate most commonly used β-lactam-based antibiotics. Among MBLs, New Delhi metallo-β-lactamase-1 (NDM-1) constitutes an urgent threat to public ...
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Open AccessRole of outer surface probes for regulating ion gating of nanochannels
Nanochannels with functional elements have shown promise for DNA sequencing, single-molecule sensing, and ion gating. Ionic current measurement is currently a benchmark, but is focused solely on the contributi...
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Open AccessDemonstration of ultra-high recyclable energy densities in domain-engineered ferroelectric films
Dielectric capacitors have the highest charge/discharge speed among all electrical energy devices, but lag behind in energy density. Here we report dielectric ultracapacitors based on ferroelectric films of Ba(Zr
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Open AccessGenome characterization of two bile-isolated Vibrio fluvialis strains: an insight into pathogenicity and bile salt adaption
Vibrio fluvialis is recognized as an emerging pathogen. However, not much is known about the mechanism of its pathogenesis, and its adaptation to a special niche such as the gall bladder....
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Open AccessModern dust aerosol availability in northwestern China
The sources of modern dust aerosols and their emission magnitudes are fundamental for linking dust with climate and environment. Using field sample data, wind tunnel experiments and statistical analysis, we de...
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Open AccessKey driving forces of desertification in the Mu Us Desert, China
The temporal trends and key driving forces of desertification in the Mu Us Desert are representatives of most arid regions of Asia with a high risk of desertification. We analyzed the significance of Aeolian t...
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Open AccessIn–situ XRD and EDS method study on the oxidation behaviour of Ni–Cu sulphide ore
The oxidation mechanism of sulfides is the key issue during the sulphide–metallurgy process. In this study, the phase transformation and element migration were clearly demonstrated by in–situ laboratory–based ...
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Open AccessImpact of genotype on endocrinal complications of Children with Alpha-thalassemia in China
Alpha-thalassemia occurs with high frenquency in China. Four common α-globin gene deletion mutations (–SEA, -α3.7, and -α4.2, Haemoglobin Constant Spring (CS) mutation) were identified in Chinese patients. Ind...