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Article
Open AccessAssociation of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not with ANCA-associated vasculitis in a Japanese population
Genome-wide association studies of systemic lupus erythematosus (SLE) in Chinese and Korean populations demonstrated strong association of single nucleotide polymorphisms (SNPs) located in the GTF2I-NCF1 region, ...
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Article
Open AccessRole of deleterious single nucleotide variants in the coding regions of TNFAIP3 for Japanese autoimmune hepatitis with cirrhosis
Autoimmune hepatitis (AIH) is an autoimmune liver disease and cirrhosis is sometimes complicated with AIH at diagnosis, influencing its prognosis. TNFAIP3 gene encodes A20, an inhibitor of nuclear factor-κB pathw...
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Article
Open AccessExpression of minor cartilage collagens and small leucine rich proteoglycans may be relatively reduced in osteoarthritic cartilage
In osteoarthritis (OA), cartilage matrix is lost despite vigorous chondrocyte anabolism. In this study, we attempted to determine whether altered matrix synthesis is involved in this paradox in disease progres...
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Article
Initial clinical evaluation of preoperative frailty in surgical patients with Stanford type A acute aortic dissection
We retrospectively assessed the initial clinical role of preoperative frailty in surgical patients with Stanford type A acute aortic dissection (AAAD).
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Article
Performance evaluation of an adaptive self-organizing frequency reuse approach for OFDMA downlink
Orthogonal frequency division multiple access (OFDMA) is extensively utilized for the downlink of cellular systems such as long term evolution (LTE) and LTE advanced. In OFDMA cellular networks, orthogonal res...
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Article
Hydroxyobtustyrene protects neuronal cells from chemical hypoxia-induced cell death
Hydroxyobtustyrene is a derivative of cinnamyl phenol isolated from Dalbergia odorifera T. Chen. The heartwood, known as ‘Jiang**ang’, is a traditional Chinese medicine. Previous studies showed that hydroxyobtust...
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Article
Surgical management of extensive dissecting thoracic aortic aneurysm via the semi-clamshell approach
We retrospectively evaluated the initial clinical experience of the surgical management of extensive dissecting thoracic aortic aneurysm (TAA) via the semi-clamshell approach.
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Article
Correction to: Multicenter phase II study of trastuzumab plus S-1 alone in elderly patients with HER2-positive advanced gastric cancer (JACCRO GC‑06)
The correct name of the twelfth author should be ‘‘Yasuhiro Yuasa”, and not ‘‘Yasuhiko Yuasa’’ as given in the original publication of the article.
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Article
Open AccessMulticenter phase II study of trastuzumab plus S-1 alone in elderly patients with HER2-positive advanced gastric cancer (JACCRO GC-06)
S-1 plus cisplatin is a standard regimen for advanced gastric cancer (AGC) in Asia. The ToGA trial established a fluoropyrimidine plus cisplatin and trastuzumab as a standard treatment for human epidermal grow...
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Chapter and Conference Paper
A Qualitative Model to Estimate Users’ Fear of Environmental Conditions for Evacuation Route Guidance
Fear has a great impact on a decision-making phase of evacuees in hazardous situations. Even if it is a safe route, evacuees may find difficulty in passing there. The aim of this study is to clarify physical c...
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Article
Open AccessEffects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still’s disease
HLA-DRB1 alleles are major determinants of genetic predisposition to rheumatic diseases. We assessed whether DRB1 alleles are associated with susceptibility to particular clinical feat...
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Article
Gastric cancer treated by endoscopic submucosal dissection or endoscopic mucosal resection in Japan from 2004 through 2006: JGCA nationwide registry conducted in 2013
The Japanese Gastric Cancer Association (JGCA) initiated a new nationwide gastric cancer registry in 2008 and reported the treatment outcomes of patients with primary gastric cancer who underwent surgical ther...
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Article
Dominant lymph drainage patterns in the occipital and parietal regions: evaluation of lymph nodes in patients with skin cancer of the head
The purpose of this study was to evaluate the superficial lymph drainage patterns of primary skin cancers of the head arising from the occipital or parietal region.
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Article
WLAN Channel Assignment Based on Minimizing the Worst-Case Interference
An optimization model for solving the channel assignment problem in multi-cell WLANs which is based on minimizing the maximum interference at access points in the network is proposed. The channel assignment pr...
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Article
Review and proposal of regional surgical management for melanoma: revisiting of integumentectomy and incontinuity dissection in treatment of skin melanoma
Past studies showed that integumentectomy and incontinuity could be effective procedures in the surgical management of melanoma patients. The present study reports on the historical background of these procedu...
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Article
Open AccessPhase 1b study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in Japanese patients with advanced melanoma (KEYNOTE-041)
This phase I b study evaluated the safety and anti-tumor activity of pembrolizumab in Japanese patients with advanced melanoma.
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Article
Open AccessThe 23-valent pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis: a double-blinded, randomized, placebo-controlled trial
Pneumococcal pneumonia is the most frequent form of pneumonia. We herein assessed the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) in the prevention of pneumonia overall in rheum...
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Article
Open AccessPlasma miRNA expression profiles in rheumatoid arthritis associated interstitial lung disease
Interstitial lung disease (ILD) is frequently associated with rheumatoid arthritis (RA), and is designated RA-associated ILD (RA-ILD). RA-ILD has a large impact on the prognosis of RA. Here, we investigated th...
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Chapter and Conference Paper
Network-Based Pedestrian Tracking System with Densely Placed Wireless Access Points
Demand for care services, especially for children and the elderly, has been increasing. Several GPS-based pedestrian tracking systems have been researched and developed, but GPS cannot provide accurate positio...
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Article
Preimplantation genetic diagnosis/screening by comprehensive molecular testing
Although embryo screening by preimplantation genetic diagnosis (PGD) has become the standard technique for the treatment of recurrent pregnancy loss in couples with a balanced gross chromosomal rearrangement, ...
