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8,699 Result(s)
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Article
Open AccessDesign of 3D printing osteotomy block for foot based on triply periodic minimal surface
The ankle joint, which connects the lower limbs and the sole of the foot, is prone to sprain during walking and sports, which leads to ankle arthritis. Supratroleolar osteotomy is an ankle preserving operation...
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Open AccessDeep Learning–Based Localization and Detection of Malpositioned Nasogastric Tubes on Portable Supine Chest X-Rays in Intensive Care and Emergency Medicine: A Multi-center Retrospective Study
Malposition of a nasogastric tube (NGT) can lead to severe complications. We aimed to develop a computer-aided detection (CAD) system to localize NGTs and detect NGT malposition on portable chest X-rays (CXRs)...
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Open AccessSerum matrix metalloproteinase-7 for discriminating biliary atresia: a diagnostic accuracy and validation study
Prompt and precise differential diagnosis of biliary atresia (BA) among cholestatic patients is of great importance. Matrix metalloproteinase-7 (MMP-7) holds great promise as a diagnostic marker for BA. This s...
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Open AccessPeroxiredoxin 1 inhibits streptozotocin-induced Alzheimer’s disease-like pathology in hippocampal neuronal cells via the blocking of Ca2+/Calpain/Cdk5-mediated mitochondrial fragmentation
Oxidative stress plays an essential role in the progression of Alzheimer’s disease (AD), the most common age-related neurodegenerative disorder. Streptozotocin (STZ)-induced abnormal brain insulin signaling an...
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STED Imaging of Vesicular Endocytosis in the Synapse
Endocytosis is a fundamental biological process that couples exocytosis to maintain the homeostasis of the plasma membrane and sustained neurotransmission. Super-resolution microscopy enables optical imaging o...
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Open AccessMulti-omics differences in the bone marrow between essential thrombocythemia and prefibrotic primary myelofibrosis
Essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (pre-PMF) are Philadelphia chromosome-negative myeloproliferative neoplasms. These conditions share overlap** clinical presentations; howe...
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Improving the ORR catalytic performance of hollow porous carbon derived from F127 assembled in ethanol-hexane mixture containing Fe3+ ion
To reduce the cost of fuel cell oxygen reduction reaction catalysts, the gels of polyethylene oxide-polypropylene oxide-polyethylene oxide (PEO-PPO-PEO) triblock copolymer (F127) and Fe(NO3)3·9H2O, formed in etha...
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Open AccessTelomere-to-telomere genome assembly of the goose Anser cygnoides
Our study presents the assembly of a high-quality Taihu goose genome at the Telomere-to-Telomere (T2T) level. By employing advanced sequencing technologies, including Pacific Biosciences HiFi reads, Oxford Nan...
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Open AccessAggregation promotes charge separation in fullerene-indacenodithiophene dyad
Fast photoinduced charge separation (CS) and long-lived charge-separated state (CSS) in small-molecules facilitate light-energy conversion, while simultaneous attainment of both remains challenging. Here we ac...
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Open AccessGenome-wide analysis of MYB transcription factor family and AsMYB1R subfamily contribution to ROS homeostasis regulation in Avena sativa under PEG-induced drought stress
The myeloblastosis (MYB) transcription factor (TF) family is one of the largest and most important TF families in plants, playing an important role in a life cycle and abiotic stress.
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Open AccessATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8+ T cells
Obesity shapes anti-tumor immunity through lipid metabolism; however, the mechanisms underlying how colorectal cancer (CRC) cells utilize lipids to suppress anti-tumor immunity remain unclear. Here, we show th...
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Open AccessDeep learning for multi-type infectious keratitis diagnosis: A nationwide, cross-sectional, multicenter study
The main cause of corneal blindness worldwide is keratitis, especially the infectious form caused by bacteria, fungi, viruses, and Acanthamoeba. The key to effective management of infectious keratitis hinges o...
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Energy partition in laser-induced cavitation bubbles near the rigid wall with a gas-containing hole
To investigate the energy partition in laser-induced cavitation bubbles near the rigid wall with a gas-containing hole, we utilized a nanosecond resolution photography system based on a Q-switched Nd: YAG lase...
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Navβ2 Intracellular Fragments Contribute to Aβ1-42-Induced Cognitive Impairment and Synaptic Deficit Through Transcriptional Suppression of BDNF
A pathological hallmark of Alzheimer’s disease (AD) is the region-specific accumulation of the amyloid-beta protein (Aβ), which triggers aberrant neuronal excitability, synaptic impairment, and progressive cog...
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Open AccessControlled Twill Surface Structure Endowing Nanofiber Composite Membrane Excellent Electromagnetic Interference Shielding
Inspired by the Chinese Knotting weave structure, an electromagnetic interference (EMI) nanofiber composite membrane with a twill surface was prepared.
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Open AccessAuthor Correction: ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice
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Correction: Profiling chromatin accessibility in pediatric acute lymphoblastic leukemia identifies subtype-specific chromatin landscapes and gene regulatory networks
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Integrated 1D epitaxial mirror twin boundaries for ultrascaled 2D MoS2 field-effect transistors
In atomically thin van der Waals materials, grain boundaries—the line defects between adjacent crystal grains with tilted in-plane rotations—are omnipresent. When the tilting angles are arbitrary, the grain bo...
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Multi-scale modeling to investigate the effects of transcranial magnetic stimulation on morphologically-realistic neuron with depression
Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique to activate or inhibit the activity of neurons, and thereby regulate their excitability. This technique has demonstrated pote...
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Cancer cost-related subjective financial distress among breast cancer: a sco** review
This article provided a comprehensive sco** review, synthesizing existing literature on the financial distress faced by breast cancer patients. It examined the factors contributing to financial distress, the...