65 Result(s)

Article

Subsets of exhausted CD8⁺ T cells differentially mediate tumor control and respond to checkpoint blockade

T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the mechanisms by which antibody blockade of the inhibitory receptor PD-1 (anti-PD-1) reinvigorates T cells are not fu...

Brian C. Miller, Debattama R. Sen, Rose Al Abosy, Kevin Bi… in Nature Immunology (2019)

Article

The diverse functions of the PD1 inhibitory pathway

Article

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

Immunotherapy with PD-1 checkpoint blockade is effective in only a minority of patients with cancer, suggesting that additional treatment strategies are needed. Here we use a pooled in vivo genetic screening appr...

Robert T. Manguso, Hans W. Pope, Margaret D. Zimmer, Flavian D. Brown… in Nature (2017)

Article

The microRNA miR-31 inhibits CD8⁺ T cell function in chronic viral infection

Wucherpfennig and colleagues show that the microRNA miR-31 increases the sensitivity of T cells to type I interferons, which interferes with effector T cell function during chronic infection.

Howell F Moffett, Adam N R Cartwright, Hye-Jung Kim, Jernej Godec… in Nature Immunology (2017)

Article

Suppression by T_FR cells leads to durable and selective inhibition of B cell effector function

Follicular regulatory T cells (T_FR cells) inhibit follicular helper T cell (T_FH cell)-mediated antibody production. Sharpe and colleagues show that T_FR cells induce a distinct suppressive state in T_FH cells and B...

Peter T Sage, Noga Ron-Harel, Vikram R Juneja, Debattama R Sen… in Nature Immunology (2016)

Article

Defining CD8⁺ T cells that provide the proliferative burst after PD-1 therapy

Chronic infection with lymphocytic choriomeningitis virus promotes the establishment of a population of stem-like PD-1⁺ CD8⁺ T cells that reside in lymphoid tissues and preferentially expand when the PD-1 inhibit...

Se ** Im, Masao Hashimoto, Michael Y. Gerner, Junghwa Lee, Haydn T. Kissick… in Nature (2016)

Chapter

Enhancing the Efficacy of Checkpoint Blockade Through Combination Therapies

Antibodies targeting coinhibitory receptors on T cells (“checkpoint blockade”) have emerged as some of the most promising therapies for a broad range of malignancies, including melanoma, non-small cell lung ca...

Vikram R. Juneja, Martin W. LaFleur… in Novel Immunotherapeutic Approaches to the … (2016)

Article

Control of PI(3) kinase in T_reg cells maintains homeostasis and lineage stability

Regulatory T cells normally maintain high expression of the phosphatase PTEN. Turka and colleagues use conditional deletion of PTEN in regulatory T cells to show that it is critical for their function and stab...

Alexandria Huynh, Michel DuPage, Bhavana Priyadharshini, Peter T Sage… in Nature Immunology (2015)

Protocol

In Vitro Assay to Sensitively Measure Tfr Suppressive Capacity and Tfh Stimulation of B Cell Responses

T follicular helper (Tfh) cells stimulate, whereas T follicular regulatory (Tfr) cells inhibit, B cell responses. Despite the potent immunoregulatory roles for Tfr cells in controlling the magnitude of antibody p...

Peter T. Sage, Arlene H. Sharpe in T follicular Helper Cells (2015)

Article

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

A carcinogen-induced mouse tumour model is used here to show that mutant tumour-specific antigens are targets for CD8⁺ T-cell responses, mediating tumour regression after checkpoint blockade immunotherapy, and th...

Matthew M. Gubin, **uli Zhang, Heiko Schuster, Etienne Caron, Jeffrey P. Ward… in Nature (2014)

Article

GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses

RIG-I–like receptors are important inducers of innate immunity. Reinecker and colleagues find that activation of the microtubule-associated guanine nucleotide exchange factor GEF-H1 is essential for sensing of...

Hao-Sen Chiang, Yun Zhao, Joo-Hye Song, Song Liu, Ninghai Wang… in Nature Immunology (2014)

Article

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood

Follicular regulatory T cells control humoral immune responses, but how these cells are in turn controlled has been unclear. Sharpe and colleagues demonstrate that signaling via PD-1 regulates number and funct...

Peter T Sage, Loise M Francisco, Christopher V Carman, Arlene H Sharpe in Nature Immunology (2013)

Article

CD28 ligation increases macrophage suppression of T-cell proliferation

When compared to spleen or lymph node cells, resident peritoneal cavity cells respond poorly to T-cell activation in vitro. The greater proportional representation of macrophages in this cell source has been show...

Daniel Silberman, Amanda Bucknum, Thomas Bartlett… in Cellular & Molecular Immunology (2012)

Article

A new therapeutic strategy for malaria: targeting T cell exhaustion

Boosting immune responses during malaria remains a challenge. Overcoming T cell exhaustion by blocking coinhibitory receptors offers a promising lead.

Gordon J Freeman, Arlene H Sharpe in Nature Immunology (2012)

Article

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

PD-1 is commonly associated with inhibitory functions, yet it is highly expressed in follicular T cells. Shlomchik and colleagues find that PD-1 signaling in germinal centers is necessary for long-lived humora...

Kim L Good-Jacobson, Courtney G Szumilas, Lie** Chen… in Nature Immunology (2010)

Article

Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells

CTLA-4 is a potent coinhibitory molecule that is critical for peripheral T cell tolerance. New data suggest that CTLA-4 exerts its critical immunoregulatory functions by controlling antigen-specific convention...

Alison M Paterson, Arlene H Sharpe in Nature Immunology (2010)