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Article
Open AccessProbability model of rock climbing recognition based on information fusion sensor time series
Rock climbing is a sports activity that integrates competition, entertainment, and culture. With the development of the economy and the improvement in living standards, rock climbing has embarked on a path of ...
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Article
The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress
The multifunctional roles of metabolic enzymes allow for the integration of multiple signals to precisely transduce external stimuli into cell fate decisions. Elevation of 3-phosphoglycerate dehydrogenase (PHG...
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Article
SIRT1 Protects Dopaminergic Neurons in Parkinson’s Disease Models via PGC-1α-Mediated Mitochondrial Biogenesis
SIRT1 is a deacetylase with multiple physiological functions by targeting histones and non-histone proteins. It has been shown that SIRT1 activation is involved in neuroprotection in Parkinson’s disease (PD) m...
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Article
The role of EVI1 gene quantification in AML patients with 11q23/MLL rearrangement after allogeneic hematopoietic stem cell transplantation
It remains unclear about the role of the EVI1 gene in AML patients with 11q23/MLL rearrangement (MLL-r AML) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). We analyzed the clinical v...
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Article
Protective effect of 2-dodecyl-6-methoxycyclohexa-2, 5-diene-1, 4-dione, isolated from Averrhoa carambola L., against Aβ1–42-induced apoptosis in SH-SY5Y cells by reversing Bcl-2/Bax ratio
Aβ1–42-induced neurotoxicity has been considered as a possible mechanism to aggravate the onset and progression of Alzheimer’s disease (AD). In this study, we aim to determine the protective effect of DMDD on ...
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Chapter and Conference Paper
Based on the Predicted Blocking Virtual Machine Load Balancing Scheduling Strategy
The popularity of the Internet and the rapid development of the massive data promote the expansion of the field of cloud computing applications, which absorb the grid computing, utility computing, and other di...
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Article
Secondary haploidentical hematopoietic stem cell transplantation in patients with relapse or graft failure after initial hematopoietic stem cell transplantation
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Article
Open AccessCorrection to: c-Src confers resistance to mitotic stress through inhibition of DMAP1/Bub3 complex formation in pancreatic cancer
Following publication of the work [1], authors reported the “flow cytometery plots” panel in Fig. 4e contained an inter-duplication in error.
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Article
Open AccessC-Src confers resistance to mitotic stress through inhibition DMAP1/Bub3 complex formation in pancreatic cancer
Chromatin modification at mitosis is closely related to transcriptional reactivation in the subsequent cell cycle. We reasoned this process is deregulated by oncogenic signals, which would contribute to mitoti...
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Article
Author Correction: Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
In the version of this Article originally published, the authors mistakenly used the same images for three different time points in Fig. 2d: images for 24 h post-IR WT were also used for 0 h post-IR WT (top ro...
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Article
Study on Spatial Pattern of Rural Settlements in Wuling Mountainous Area Based on GIS
Rural settlement is a living space of various people in rural area and it is the carrier of rural population spatial distribution. Taking Pengshui County of Wuling Mountainous Area in China as an empirical res...
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Article
Open AccessPKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation
EGFR signaling is implicated in NF-κB activation. However, the concrete mechanisms by which the core transducer of NF-κB signaling pathway, RelA/p65 is regulated under EGFR activation remains to be further cla...
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Article
O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency
Chromatin-associated fumarase (FH) affects histone methylation via its metabolic activity. However, whether this effect is involved in gene transcription remains to be clarified. In this study, we show that un...
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Article
Laminar flow and chaotic advection mixing performance in a static mixer with perforated helical segments
The laminar flow and chaotic mixing characteristics of a high-viscosity fluid in static mixers with staggered perforated helical segments were numerically investigated in the range of Re=0.1-150. The numerical...
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Article
Correction: Corrigendum: A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation
Nature Cell Biology 18, 561–571 (2016); published online 18 April 2016; corrected after print 27 April 2016 In the version of this Article originally published, the affiliations for Gilbert Cote, Hongxia Wang ...
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Article
A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation
Dietary fructose is primarily metabolized in the liver. Here we demonstrate that, compared with normal hepatocytes, hepatocellular carcinoma (HCC) cells markedly reduce the rate of fructose metabolism and the ...
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Article
Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
Histone methylation regulates DNA repair. However, the mechanisms that underlie the regulation of histone methylation during this repair remain to be further defined. Here, we show that exposure to ionizing ra...
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Chapter and Conference Paper
Travel Recommendation via Author Topic Model Based Collaborative Filtering
While automatic travel recommendation has attracted a lot of attentions, the existing approaches generally suffer from different kinds of weaknesses. For example, sparsity problem can significantly degrade the...
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Article
PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells
Pyruvate kinase M2 (PKM2) is expressed at high levels during embryonic development and tumour progression and is important for cell growth. However, it is not known whether it directly controls cell division. ...
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Article
PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus
Ras plays a pivotal role in many cellular activities, and its subcellular compartmentalization provides spatial and temporal selectivity. Here we report a mode of spatial regulation of Ras signaling in the Gol...
