1,615 Result(s)
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Correction: Evolution of Microstructure and Mechanical Properties in Dual-Phase Steel Containing Ce and Nb
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Open AccessRandom-access wide-field mesoscopy for centimetre-scale imaging of biodynamics with subcellular resolution
Benefitting from the advantages of high imaging throughput and low cost, wide-field microscopy has become indispensable in biomedical studies. However, it remains challenging to record biodynamics with a large...
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Open AccessYAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis
The senescence of alveolar type II (AT2) cells impedes self-repair of the lung epithelium and contributes to lung injury in the setting of idiopathic pulmonary fibrosis (IPF). Yes-associated protein 1 (YAP1) i...
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Open AccessRoles of non-coding RNA in diabetic cardiomyopathy
In recent years, the incidence of diabetes has been increasing rapidly, posing a serious threat to human health. Diabetic cardiomyopathy (DCM) is characterized by cardiomyocyte hypertrophy, myocardial fibrosis...
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Open AccessEmerging probing perspective of two-dimensional materials physics: terahertz emission spectroscopy
Terahertz (THz) emission spectroscopy (TES) has emerged as a highly effective and versatile technique for investigating the photoelectric properties of diverse materials and nonlinear physical processes in the...
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Open AccessSimulating urban energy use under climate change scenarios and retrofit plans in coastal Texas
Rapid urbanization, climate change, and aging infrastructure pose significant challenges to achieving sustainability and resilience goals in urban building energy use. Although retrofitting offers a viable so...
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Open AccessIdentification of four TTN variants in three families with fetal akinesia deformation sequence
TTN is a complex gene with large genomic size and highly repetitive structure. Pathogenic variants in TTN have been reported to cause a range of skeletal muscle and cardiac disorders. Homozygous or compound heter...
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Open AccessRadiographic evaluation of robot-assisted versus manual total hip arthroplasty: a multicenter randomized controlled trial
The effectiveness of robot-assisted surgery remains contentious due to the lack of high-quality randomized controlled trials (RCTs) to elevate the level of evidence. We aimed to evaluate the postoperative radi...
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Open AccessMultimodal neuroimaging exploration of the mechanisms of sleep quality deterioration after SARS-CoV-2 Omicron infection
To evaluate the neurological alterations induced by Omicron infection, to compare brain changes in chronic insomnia with those in exacerbated chronic insomnia in Omicron patients, and to examine individuals wi...
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Open AccessThe thickness change ratio and preservation ratio of the infrapatellar fat pad are related to anterior knee pain in patients following medial patellofemoral ligament reconstruction
The infrapatellar fat pad (IPFP) lies extrasynovial and intracapsular, preserving the joint cavity and serving as a biochemical regulator of inflammatory reactions. However, there is a lack of research on the ...
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Open AccessIndividualized dynamic frailty-tailored therapy (DynaFiT) in elderly patients with newly diagnosed multiple myeloma: a prospective study
It remains a substantial challenge to balance treatment efficacy and toxicity in geriatric patients with multiple myeloma (MM), primarily due to the dynamic nature of frailty. Here, we conducted a prospective ...
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Open AccessChromosome-level genome assembly of Cnidium monnieri, a highly demanded traditional Chinese medicine
Cnidium monnieri, a medicinal herb of the Cnidium genus and the Apiaceae family, is among the most important traditional Chinese medicines and is widely distributed in China. However, to date, no C. monnieri-rela...
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Open AccessFitness effects of synthetic and natural diet preservatives on the edible insect Bombyx mori
Silkworm pupae as widely consumed insect products are good biosources of protein and micronutrients. Silkworm rearing throughout the year can be achieved by feeding them an artificial diet instead of native pl...
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Open AccessLIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism
LIMA1 is a LIM domain and Actin binding 1 protein that acts as a skeleton protein to promote cholesterol absorption, which makes it an ideal target for interfering with lipid metabolism. However, the detailed ...
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Open AccessTumor mutational burden adjusted by neutrophil-to-lymphocyte ratio serves as a potential biomarker for atezolizumab-treated patients with extensive stage small cell lung cancer
There is a desperate for the identification of more accurate and efficient biomarkers for ICI responses in patients with SCLC.
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Open AccessRBC transfusion and necrotizing enterocolitis in very preterm infants: a multicenter observational study
The causal relationship between Packed red blood cell (RBC) transfusion and necrotizing enterocolitis (NEC) remains uncertain. This study aims to provide an exploration of transfusion and NEC in very preterm i...
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Open AccessATP biosensor reveals microbial energetic dynamics and facilitates bioproduction
Adenosine-5’-triphosphate (ATP), the primary energy currency in cellular processes, drives metabolic activities and biosynthesis. Despite its importance, understanding intracellular ATP dynamics’ impact on bio...
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Open AccessComparison of tacrolimus with or without prednisone therapy in primary membranous nephropathy: a retrospective clinical study
Previous studies showed tacrolimus monotherapy and dual therapy with tacrolimus and prednisone as effective treatment modalities in managing membranous nephropathy. However, few studies have compared these the...
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Open AccessBayesian-frequentist hybrid inference framework for single cell RNA-seq analyses
Single cell RNA sequencing technology (scRNA-seq) has been proven useful in understanding cell-specific disease mechanisms. However, identifying genes of interest remains a key challenge. Pseudo-bulk methods t...
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Open AccessEffectiveness of repetitive transcranial magnetic stimulation for insomnia disorder on fear memory extinction: study protocol for a randomised controlled trial
Fear memory extinction is closely related to insomnia. Repetitive transcranial magnetic stimulation (rTMS) is safe and effective for treating insomnia disorder (ID), and it has been shown to be an efficient me...