99 Result(s)

Article

CLEC5A mediates Zika virus-induced testicular damage

Zika virus (ZIKV) infection is clinically known to induce testicular swelling, termed orchitis, and potentially impact male sterility, but the underlying mechanisms remain unclear. Previous reports suggested t...

Hsin-Wei Wang, Hsing-Han Li, Shih-Cheng Wu… in Journal of Biomedical Science (2023)

Article

Author Correction: Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle

Li-wen Ren, Wan Li, **ang-** Zheng, **-yi Liu, Yi-hui Yang… in Acta Pharmacologica Sinica (2023)

Article

Splicing factor-mediated regulation patterns reveals biological characteristics and aid in predicting prognosis in acute myeloid leukemia

Alternative splicing (AS) of RNA is a fundamental biological process that shapes protein diversity. Many non-characteristic AS events are involved in the onset and development of acute myeloid leukemia (AML). ...

Fang-Min Zhong, Fang-Yi Yao, **g Liu, Mei-Yong Li… in Journal of Translational Medicine (2023)

Article

Secretory autophagy promotes Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1

Rab37-mediated exocytosis of tissue inhibitor of metalloproteinase 1 (TIMP1), an inflammatory cytokine, under serum-depleted conditions which leads to suppression of lung cancer cell metastasis has been report...

Shan-Ying Wu, Jia-Wen Chen, Hsi-Yu Liu, Yi-Ching Wang… in Journal of Biomedical Science (2022)

Article

CpG-binding protein CFP1 promotes ovarian cancer cell proliferation by regulating BST2 transcription

Epigenetic alterations have been functionally linked to ovarian cancer development and occurrence. The CXXC zinc finger protein 1 (CFP1) is an epigenetic regulator involved in DNA methylation and histone modif...

Liu-Qing Yang, Han-Yin Hu, Yao Han, Ze-Yi Tang, Jie Gao, Qi-Yin Zhou… in Cancer Gene Therapy (2022)

Article

Author Correction: Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis

**ang-** Zheng, Wen-lin Chen, Jie Yi, Wan Li, **-yi Liu… in Acta Pharmacologica Sinica (2022)

Article

MiR-199a/b-3p inhibits colorectal cancer cell proliferation, migration and invasion through targeting PAK4 and BCAR3

Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. P21 activated kinase 4 (PAK4) and Breast cancer anti-estrogen resistance 3 (BCAR3) have been reported to be involved in nume...

Junjie Hou, Xuguang Mi, Ning Liu, **aonan Li… in European Journal of Medical Research (2022)

Article

A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variants

With the continuous emergence of new SARS-CoV-2 variants that feature increased transmission and immune escape, there is an urgent demand for a better vaccine design that will provide broader neutralizing effi...

I-Jung Lee, Cheng-Pu Sun, **-Yi Wu, Yu-Hua Lan… in Journal of Biomedical Science (2022)

Article

DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction

Tight junctions (TJ) are multi-protein complexes that hold epithelial cells together and form structural and functional barriers for maintaining proper biological activities. Dual specificity phosphatase 3 (DU...

Hsiao-Chin Chou, Chun-Mei Cheng, Chi-Hwa Yang, Tzu-Yin Lin… in Journal of Biomedical Science (2022)

Article

Induction of high affinity monoclonal antibodies against SARS-CoV-2 variant infection using a DNA prime-protein boost strategy

Calls for the coronavirus to be treated as an endemic illness, such as the flu, are increasing. After achieving high coverage of COVID-19 vaccination, therapeutic drugs have become important for future SARS-Co...

Chen-Yi Chiang, Mei-Yu Chen, Chia-Wei Hsu, Chia-Yeh Liu… in Journal of Biomedical Science (2022)

Article

A DNA vaccine candidate delivered by an electroacupuncture machine provides protective immunity against SARS-CoV-2 infection

A major challenge in the use of DNA vaccines is efficient DNA delivery in vivo. Establishing a safe and efficient electric transfer method is the key to develo** rapid DNA vaccines against emerging infectiou...

Tsai-Teng Tzeng, Kit Man Chai, Kuan-Yin Shen, Chia-Yi Yu, Shiu-Ju Yang… in npj Vaccines (2022)

Article

Long noncoding RNA BCRP3 stimulates VPS34 and autophagy activities to promote protein homeostasis and cell survival

Autophagy plays important roles in cell homeostasis and protein quality control. Long non-coding RNAs (lncRNAs) have been revealed as an emerging class of autophagy regulators, but the majority of them functio...

Ruei-Liang Yan, Chiu-Lin Luan, Chun-Chieh Liao… in Journal of Biomedical Science (2022)

Article

Chinese herbal formula Tongxie Yaofang for diarrhea-predominant irritable bowel syndrome: study protocol for a randomized, multiple-blind, placebo-controlled trial

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a bowel disease with a high incidence. It significantly reduces the quality of life of patients and affects the patient's daily activities and mental he...

Shi-Bing Liang, Mei Han, Hong-Jie Cheng, Qiao-Yan Zhang, Nai-Wei Zhang, Bo-Yi Jia… in Trials (2022)

Article

Specific immune status in Parkinson’s disease at different ages of onset

Recent evidence suggests that innate and adaptive immunity play a crucial role in Parkinson’s disease (PD). However, studies regarding specific immune cell classification in the peripheral blood in PD remain l...

Jun Tian, Shao-Bing Dai, Si-Si Jiang, Wen-Yi Yang, Yi-Qun Yan… in npj Parkinson's Disease (2022)

Article

Effects of immunoglobulin plus prednisolone in reducing coronary artery lesions in patients with Kawasaki disease: study protocol for a phase III multicenter, open-label, blinded-endpoints randomized controlled trial

Kawasaki disease (KD) is an acute systemic vasculitis of unclear etiology that mainly affects infants and young children. Strategies to reduce the incidence and severity of coronary artery lesions (CALs), the ...

Si-Yuan Lin, Lan He, Li-** **e, Yin Wang, Yi-**ang Lin, Yin-Yin Cao, Wei-Li Yan… in Trials (2021)

Article

Surgery alone, adjuvant tegafur/gimeracil/octeracil (S-1), or platinum-based chemotherapies for resectable gastric cancer: real-world experience and a propensity score matching analysis

Adjuvant chemotherapy has changed the paradigm in resectable gastric cancer. S-1 is an oral chemotherapeutic with promising efficacy in Asia. However, comparisons with close observation or platinum-based doubl...

Chih-Chieh Yen, Yan-Shen Shan, Ying-Jui Chao, Ting-Kai Liao, I-Shu Chen… in BMC Cancer (2021)

Article

MRI contributes to accurate and early diagnosis of non-radiographic HLA-B27 negative axial spondyloarthritis

Nonradiographic axial spondyloarthropathies (nr-axSpA) are diagnosed by the absence of radiographic sacroiliitis and the presence of bone marrow edema (BME) on magnetic resonance imaging (MRI). According to th...

Chun-Chi Lu, Guo-Shu Huang, Tony Szu-Hsien Lee… in Journal of Translational Medicine (2021)

Article

Association between ABO and Duffy blood types and circulating chemokines and cytokines

Blood group antigens are inherited traits that may play a role in immune and inflammatory processes. We investigated associations between blood groups and circulating inflammation-related molecules in 3537 non...

Sarah C. Van Alsten, John G. Aversa, Loredana Santo… in Genes & Immunity (2021)

Article

A retrospective study of alectinib versus ceritinib in patients with advanced non–small-cell lung cancer of anaplastic lymphoma kinase fusion in whom crizotinib treatment failed

Crizotinib is the approved treatment for advanced non-small cell lung cancers (NSCLCs) of anaplastic lymphoma kinase (ALK) fusion. Failure of crizotinib treatment frequently involves drug intolerance or resist...

Chih-Hsi Scott Kuo, Pi-Hung Tung, Allen Chung-Cheng Huang, Chin-Chou Wang… in BMC Cancer (2021)

Article

Comprehensive molecular profiling of Taiwanese breast cancers revealed potential therapeutic targets: prevalence of actionable mutations among 380 targeted sequencing analyses

Breast cancer is one of the leading causes of cancer-related deaths in women, and there is a demand in develo** an Asian-based genetic profiling database for breast cancer in improving the treatment response...

Chi-Cheng Huang, Yi-Fang Tsai, Chun-Yu Liu, Ta-Chung Chao, Pei-Ju Lien… in BMC Cancer (2021)