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Article
Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner
Posttranslational modifications add tremendous complexity to proteomes; however, gaps remain in knowledge regarding the function and regulatory mechanism of newly discovered lysine acylation modifications. Her...
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Article
Production of MSTN knockout porcine cells using adenine base-editing-mediated exon skip**
Gene-knockout pigs have important applications in agriculture and medicine. Compared with CRISPR/Cas9 and cytosine base editing (CBE) technologies, adenine base editing (ABE) shows better safety and accuracy i...
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Article
miR-378a-3p promotes renal cell carcinoma proliferation, migration, and invasion by targeting TOB2
Renal cell carcinoma (RCC) is one of the most common malignant tumors of the urinary system, which has high metastasis. MicroRNAs (miRNAs) have been reported to participate in RCC progression. The present stud...
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Article
Intelligent optimization of stiffener unit cell via variational autoencoder-based feature extraction
Grid-stiffened structures are widely used in industrial equipment, where the layout of stiffener unit cells is critical in the structural performance. However, owing to the lack of design techniques, existing ...
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Article
Open AccessThermal-inert and ohmic-contact interface for high performance half-Heusler based thermoelectric generator
Unsatisfied electrode bonding in half-Heusler devices renders thermal damage and large efficiency loss, which limits their practical service at high temperatures. Here, we develop a thermodynamic strategy to s...
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Article
NLRP3 inflammasome: a potential target for predicting arrhythmia recurrence after atrial fibrillation ablation
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Article
A Novel Splicing Mutation c.335–1 G > A in the Cardiac Transcription Factor NKX2-5 Leads to Familial Atrial Septal Defect Through miR-19 and PYK2
Mutations of NKX2-5 largely contribute to congenital heart diseases (CHDs), especially atrial septal defect (ASD). We identified a novel heterozygous splicing mutation c.335-1G > A in NKX2-5 gene in an ASD family...
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Article
Extracting useful high-frequency information from wide-field electromagnetic data using time-domain signal reconstruction
The wide-field electromagnetic method is widely used in hydrocarbon exploration, mineral deposit detection, and geological disaster prediction. However, apparent resistivity and normalized field amplitude exce...
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Article
Vanadium nitride nanoparticles embedded in carbon matrix with pseudocapacitive behavior for high performance lithium-ion capacitors
Lithium-ion capacitors (LICs) have attracted wide attention due to their potential of achieving merits of high-power output as well as high energy density. However, the key issue of kinetics mismatch between a...
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Article
Open AccessFour calcium signaling pathway-related genes were upregulated in microcystic adnexal carcinoma: transcriptome analysis and immunohistochemical validation
Microcystic adnexal carcinoma (MAC) is a skin cancer with challenges in diagnosis and management. This study was aimed to detect molecular alterations of MAC and guide its pathologic diagnosis and treatment.
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Article
Open AccessClinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia (2021 Edition)
Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Tran...
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Article
Open AccessAn integrated study of Violae Herba (Viola philippica) and five adulterants by morphology, chemical compositions and chloroplast genomes: insights into its certified plant origin
Viola philippica Cav. is the only original plant for Violae Herba, as described in the Chinese Pharmacopoeia. The quality of this crude drug is affected by several adulterants from congeneric Viola species, and t...
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Article
Innovative ochre processing and tool use in China 40,000 years ago
Homo sapiens was present in northern Asia by around 40,000 years ago, having replaced archaic populations across Eurasia after episodes of earlier population expansions and interbreeding1–4. Cultural adaptations ...
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Article
Open AccessTNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models
Ferroptosis is a nonapoptotic cell death process that requires cellular iron and the accumulation of lipid peroxides. In progressive rheumatoid arthritis (RA), synovial fibroblasts proliferate abnormally in th...
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Article
Open AccessGut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients
COVID-19 is an infectious disease characterized by multiple respiratory and extrapulmonary manifestations, including gastrointestinal symptoms. Although recent studies have linked gut microbiota to infectious ...
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Article
Burnup optimization of once-through molten salt reactors using enriched uranium and thorium
The advantages of once-through molten salt reactors include readily available fuel, low nuclear proliferation risk, and low technical difficulty. It is potentially the most easily commercialized fuel cycle mod...
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Article
Open AccessMicroRNA expression signature and target prediction in familial and sporadic primary macronodular adrenal hyperplasia (PMAH)
Primary macronodular adrenal hyperplasia (PMAH), previously termed ACTH-independent macronodular adrenal hyperplasia (AIMAH), is a rare cause of Cushing’s syndrome usually characterized by functioning adrenal ...
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Article
Open AccessCharacterization of novel CTNNB1 mutation in Craniopharyngioma by whole-genome sequencing
Craniopharyngioma (CP) is rare histologically benign but clinically challenging tumor because of its intimate relationship with the critical structure in the central brain. CP can be divided into two major his...
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Article
The atlas of ferroicity in two-dimensional MGeX3 family: Room-temperature ferromagnetic half metals and unexpected ferroelectricity and ferroelasticity
Two-dimensional (2D) ferromagnetic and ferroelectric materials attract unprecedented attention due to the spontaneous-symmetry-breaking induced novel properties and multifarious potential applications. Here we...
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Article
Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice
Female ovaries degenerate about 20 years earlier than testes leading to reduced primordial follicle reserve and a reduction in oocyte quality. Here we found that bridge integrator 2 (BIN2) is enriched in mouse...
