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Article
Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis
Stimulation of adult cardiomyocyte proliferation is a promising strategy for treating myocardial infarction (MI). Earlier studies have shown increased CCL2 levels in plasma and cardiac tissue both in MI patien...
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Article
Enhanced cyclic stability of partially disordered spinel cathodes through direct fluorination with gaseous fluorine
Spinel-type cathodes are considered an optimal substitute for conventional layered oxide cathodes owing to their use of inexpensive and earth-abundant manganese as the redox-active element. Moreover, the intro...
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Article
High-entropy oxide-supported platinum nanoparticles for efficient hydrogen evolution reaction
High-entropy oxides (HEOs) are a new class of single-phase structures with unique electronic and catalytic properties; therefore, it is worthwhile to explore their applications in electrocatalysis. In this stu...
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Article
Open AccessBiochemical characterization of a multiple prenyltransferase from Tolypocladium inflatum
Prenylation plays a pivotal role in the diversification and biological activities of natural products. This study presents the functional characterization of TolF, a multiple prenyltransferase from Tolypocladium ...
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Article
Open AccessImpact of metabolic syndrome on bone mineral density in men over 50 and postmenopausal women according to U.S. survey results
Metabolic Syndrome (MetS) and bone mineral density (BMD) have shown a controversial link in some studies. This research aims to study their association in males over 50 and postmenopausal females using Nationa...
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Article
Open AccessTrimethylamine N-oxide impairs β-cell function and glucose tolerance
β-Cell dysfunction and β-cell loss are hallmarks of type 2 diabetes (T2D). Here, we found that trimethylamine N-oxide (TMAO) at a similar concentration to that found in diabetes could directly decrease glucose...
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Article
Open AccessLactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model
Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate ...
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Article
Open AccessApplication of fluorocarbon nanoparticles of 131I-fulvestrant as a targeted radiation drug for endocrine therapy on human breast cancer
Breast cancer is the most prevalent malignant tumor among women, with hormone receptor-positive cases constituting 70%. Fulvestrant, an antagonist for these receptors, is utilized for advanced metastatic hormo...
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Article
Open AccessNew clinical trial design in precision medicine: discovery, development and direction
In the era of precision medicine, it has been increasingly recognized that individuals with a certain disease are complex and different from each other. Due to the underestimation of the significant heterogene...
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Article
Aerodynamic effects of trains circulating through a bifurcated tunnel
In practice, bifurcated railway tunnels are occasionally employed in the construction of long tunnels due to specific geological reasons. However, the aerodynamic behaviors of trains moving through such comple...
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Article
The genesis and resource potential of gold deposits in the Liaodong Peninsula
Plenty of gold deposits related to Late Mesozoic craton destruction are widely distributed in eastern North China Craton. However, significant differences in research degrees, ore-forming characteristics, and ...
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Article
Electrostatically connected nanoarchitected electrocatalytic films for boosted water splitting
Active sites of two-dimensional (2D) electrocatalysts are often partially blocked owing to their inevitable stacking and hydrophobic polymeric binders in macroscale electrodes, therefore impeding their applica...
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Article
Volume-based 18F-FDG PET/CT predicts prognosis and outcome of active surveillance for intra-abdominal desmoid tumor
Desmoid tumor (DT) is a rare monoclonal, fibroblastic proliferation characterized by a variable and often unpredictable clinical course. Initial active surveillance is recommended by current guideline, and sur...
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Article
Open AccessAge-, sex- and proximal–distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates
The incidence of intestinal diseases increases with age, yet the mechanisms governing gut aging and its link to diseases, such as colorectal cancer (CRC), remain elusive. In this study, while considering age, ...
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Article
Open AccessGlobal freshwater fish invasion linked to the presence of closely related species
In the Anthropocene, non-native freshwater fish introductions and translocations have occurred extensively worldwide. However, their global distribution patterns and the factors influencing their establishment...
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Article
Open AccessZbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling
Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia, and recent epidemiological studies suggested type 2 diabetes mellitus (T2DM) is an independent risk factor for the development of AF...
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Article
Research on the knee region of cosmic ray by using a novel type of electron–neutron detector array
By accurately measuring composition and energy spectrum of cosmic ray, the origin problem of so called “knee” region (energy >one PeV) can be solved. However, up to the present, the results of the spectrum in ...
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Article
Open AccessTransport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain
Bilirubin is mainly generated from the breakdown of heme when red blood cells reach the end of their lifespan. Accumulation of bilirubin in human body usually leads to various disorders, including jaundice and...
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Article
Open AccessAddendum: Cellular differentiation into hyphae and spores in halophilic archaea
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Article
Engineering molecular regulation for SiOx with long-term stable cycle and high Coulombic efficiency as lithium-ion battery anodes
In the current situation where the practical application of silicon anode materials encounters great challenges, silicon oxide (SiOx, 0 ≤ x ≤ 2) has attracted the attention of researchers due to its relatively sm...
