95 Result(s)

Article

Long non-coding RNA NORAD promotes pancreatic cancer stem cell proliferation and self-renewal by blocking microRNA-202-5p-mediated ANP32E inhibition

Cancer stem cells (CSCs) are key regulators in the processes of tumor initiation, progression, and recurrence. The mechanism that maintains their stemness remains enigmatic, although the role of several long n...

Yu-Shui Ma, **ao-Li Yang, Yu-Shan Liu, Hua Ding… in Journal of Translational Medicine (2021)

Article

The genomic architecture of EBV and infected gastric tissue from precursor lesions to carcinoma

Epstein-Barr virus (EBV)-associated gastric carcinomas (EBVaGCs) present unique molecular signatures, but the tumorigenesis of EBVaGCs and the role EBV plays during this process remain poorly understood.

Zhang-Hua Chen, Shu-Mei Yan, **-** Chen, Qi Zhang, Shang-**n Liu… in Genome Medicine (2021)

Article

Optimization of cerebral organoids: a more qualified model for Alzheimer’s disease research

Alzheimer’s disease (AD) is a neurodegenerative disease that currently cannot be cured by any drug or intervention, due to its complicated pathogenesis. Current animal and cellular models of AD are unable to m...

Feng-Chen Bi, **n-He Yang, **ao-Yu Cheng, Wen-Bin Deng… in Translational Neurodegeneration (2021)

Article

Identification of the potential novel biomarkers as susceptibility gene for Wilms tumor

Wilms tumor (WT) is the most common malignant renal tumor in children. The aim of this study was to identify potential susceptibility gene of WT for better prognosis.

Li Liu, Zhe Song, Xu-Dong Gao, **an Chen, **ao-Bin Wu, Mi Wang, Yu-De Hong in BMC Cancer (2021)

Article

Prevalence and outcomes of re-positive nucleic acid tests in discharged COVID-19 patients

The prevalence and outcomes of patients who had re-activation of coronavirus disease 2019 (COVID-19) after discharge remain poorly understood. We included 126 consecutively confirmed cases of COVID-19 with 2-m...

Hou-wei Du, Jun-nian Chen, **ao-bin Pan… in European Journal of Clinical Microbiology … (2021)

Article

Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury

Spinal cord injury (SCI) favors a persistent pro-inflammatory macrophages/microglia-mediated response with only a transient appearance of anti-inflammatory phenotype of immune cells. However, the mechanisms co...

Hong Fan, Hai-Bin Tang, Zhe Chen, Hu-Qing Wang, Lei Zhang… in Journal of Neuroinflammation (2020)

Article

Clinical presentation and prognostic analysis of adult patients with Langerhans cell histiocytosis with pulmonary involvement

The study aimed to investigate the clinical features and prognosis factors of adult patients with Langerhans cell histiocytosis (LCH) with pulmonary involvement, especially multisystem (MS) LCH with pulmonary ...

Hui-lei Miao, Ai-lin Zhao, Ming-hui Duan, Dao-bin Zhou, **n-xin Cao, Jian Li in BMC Cancer (2020)

Article

CDK5RAP3 as tumour suppressor negatively regulates self-renewal and invasion and is regulated by ERK1/2 signalling in human gastric cancer

Toward identifying new strategies to target gastric cancer stem-like cells (CSCs), we evaluated the function of the tumour suppressor CDK5 regulatory subunit-associated protein 3 (CDK5RAP3) in gastric CSC main...

Jian-xian Lin, Changhwan Yoon, ** Li, Sandra W. Ryeom… in British Journal of Cancer (2020)

Article

MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling

Microglial polarization is a dynamic response to acute brain hypoxia induced by stroke and traumatic brain injury (TBI). However, studies on the polarization of microglia in chronic cerebral circulation insuff...

Meng Mao, Yi Xu, **n-Yu Zhang, Lin Yang, **ao-bin An… in Journal of Neuroinflammation (2020)

Article

m⁶A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling

BATF2, also known as SARI, has been implicated in tumor progression. However, its role, underlying mechanisms, and prognostic significance in human gastric cancer (GC) are elusive.

Jian-Wei **e, **ao-Bo Huang, Qi-Yue Chen, Yu-Bin Ma, Ya-Jun Zhao… in Molecular Cancer (2020)

Article

Disease-free survival as a surrogate endpoint for overall survival in adjuvant trials of pancreatic cancer: a meta-analysis of 20 randomized controlled trials

We aimed to assess whether disease-free survival (DFS) could serve as a reliable surrogate endpoint for overall survival (OS) in adjuvant trials of pancreatic cancer.

Run-Cong Nie, Xue-Bin Zou, Shu-Qiang Yuan, Ying-Bo Chen, Shi Chen… in BMC Cancer (2020)

Article

Prevalence of monoclonal gammopathy of undetermined significance in a large population with annual medical check-ups in China

Jian-hua Han, Ji-nuo Wang, Yue-lun Zhang, **n-xin Cao, Dao-bin Zhou… in Blood Cancer Journal (2020)

Article

Correction to: Next-generation sequencing-based genetic landscape and its clinical implications for Chinese acute myeloid leukemia patients

Following publication of the original article [1], we have been notified that the data in Fig. 1 was wrongly presented. The correct Fig. 1 is presented below.

**n-xin Cao, Hao Cai, Yue-ying Mao, Qi Wu, Lu Zhang… in Cancer Cell International (2019)