407 Result(s)

Article

USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy

Drug resistance in cancer therapy is the major reason for poor prognosis. Addressing this clinically unmet issue is important and urgent. In this study, we found that targeting USP24 by the specific USP24 inhi...

Ming-Jer Young, Shao-An Wang, Yung-Ching Chen, Chia-Yu Liu… in Cell Death & Differentiation (2024)

Article

Arsenic trioxide augments immunogenic cell death and induces cGAS-STING-IFN pathway activation in hepatocellular carcinoma

The treatment of hepatocellular carcinoma (HCC) is particularly challenging due to the inherent tumoral heterogeneity and easy resistance towards chemotherapy and immunotherapy. Arsenic trioxide (ATO) has emer...

**n Li, Yu-Fei Pan, Yi-Bin Chen, Qian-Qian Wan, Yun-Kai Lin… in Cell Death & Disease (2024)

Article

Retraction Note: Forkhead factor FOXQ1 promotes TGF-β1 expression and induces epithelial–mesenchymal transition

Dong-Mei Fan, **ao-Shan Feng, Peng-Wei Qi… in Molecular and Cellular Biochemistry (2024)

Article

OTUB1/NDUFS2 axis promotes pancreatic tumorigenesis through protecting against mitochondrial cell death

Pancreatic cancer is one of the most fatal cancers in the world. A growing number of studies have begun to demonstrate that mitochondria play a key role in tumorigenesis. Our previous study reveals that NDUFS2 (N...

**ao-Dong Huang, Li Du, **ao-Chen Cheng, Yu-**n Lu, Qiao-Wei Liu… in Cell Death Discovery (2024)

Article

Increased miR-3074-5p expression promotes M1 polarization and pyroptosis of macrophages via ERα/NLRP3 pathway and induces adverse pregnancy outcomes in mice

Decidual macrophages (dMϕs) play critical roles in regulation of immune-microhomeostasis at maternal-fetal interface during pregnancy, but the underlying molecular mechanisms are still unclear. In this study, ...

Long Yang, Hao-Ran Xu, Xuan Zhang, Yan Shi, Jia-**n Shi… in Cell Death Discovery (2024)

Article

Kinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosis

Kinesin family member 3A (KIF3A) is a microtubule-oriented motor protein that belongs to the kinesin-2 family for regulating intracellular transport and microtubule movement. In this study, we characterized th...

**g-Cai Liu, Zhen-Nan Pan, Jia-Qian Ju… in Cellular and Molecular Life Sciences (2024)

Article

Correction: Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease

Wen-Dai Bao, Pei Pang, **ao-Ting Zhou, Fan Hu, Wan **ong… in Cell Death & Differentiation (2024)

Article

Neonatal GABAergic transmission primes vestibular gating of output for adult spatial navigation

GABAergic interneurons are poised with the capacity to shape circuit output via inhibitory gating. How early in the development of medial vestibular nucleus (MVN) are GABAergic neurons recruited for feedforwar...

Qiufen Jiang, Kenneth Lap-Kei Wu, **ao-Qian Hu… in Cellular and Molecular Life Sciences (2024)

Article

Correction: LncRNA SNHG1 and RNA binding protein hnRNPL form a complex and coregulate CDH1 to boost the growth and metastasis of prostate cancer

**ao Tan, Wen-bin Chen, Dao-jun Lv, Tao-wei Yang, Kai-hui Wu… in Cell Death & Disease (2024)

Article

MCL1 inhibition: a promising approach to augment the efficacy of sorafenib in NSCLC through ferroptosis induction

Ferroptosis, an iron-dependent form of regulated cell death, plays a crucial role in modulating the therapeutic response in non-small cell lung cancer (NSCLC) patients. Studies have identified the signal trans...

Chao-Yuan Huang, Li-Ju Chen, Chi-Shuo Chen, Cheng-Yi Wang… in Cell Death Discovery (2024)

Article

Exploring the plant lipidome: techniques, challenges, and prospects

Plant lipids are a diverse group of biomolecules that play essential roles in plant architecture, physiology, and signaling. To advance our understanding of plant biology and facilitate innovations in plant-ba...

Hao-Zhuo Liu, Yong-Kang Li, Yi-Li Chen, Ying Zhou… in Advanced Biotechnology (2024)

Article

Disrupting PIAS3-mediated SUMOylation of MLK3 ameliorates poststroke neuronal damage and deficits in cognitive and sensorimotor behaviors

Activated small ubiquitin-like modifiers (SUMOs) have been implicated in neuropathological processes following ischemic stroke. However, the target proteins of SUMOylation and their contribution to neuronal in...

Yu Jiang, Lulu Hu, Baixue Wang, Bingge Zhang… in Cellular and Molecular Life Sciences (2024)

Article

Activation of human STING by a molecular glue-like compound

Stimulator of interferon genes (STING) is a dimeric transmembrane adapter protein that plays a key role in the human innate immune response to infection and has been therapeutically exploited for its antitumor...

Jie Li, Stephen M. Canham, Hua Wu, Martin Henault, Lihao Chen… in Nature Chemical Biology (2024)

Article

IGF-1-mediated FOXC1 overexpression induces stem-like properties through upregulating CBX7 and IGF-1R in esophageal squamous cell carcinoma

Substantial evidence attests to the pivotal role of cancer stem cells (CSC) in both tumorigenesis and drug resistance. A member of the forkhead box (FOX) family, FOXC1, assumes significance in embryonic develo...

Hao Wu, Zhao-**ng Li, Kang Fang, Zi-Ying Zhao, Ming-Chuang Sun… in Cell Death Discovery (2024)

Article

miR-324-3p Suppresses Hepatic Stellate Cell Activation and Hepatic Fibrosis Via Regulating SMAD4 Signaling Pathway

In hepatic fibrosis (HF), hepatic stellate cells (HSCs) form the extracellular matrix (ECM), and the pathological accumulation of ECM in the liver leads to inflammation. Our previous research found that miR-32...

Si-Yu Chen, **n Chen, Sai Zhu, **-** Xu, **ao-Feng Li… in Molecular Biotechnology (2024)

Article

Advanced oxidation protein products attenuate the autophagy-lysosome pathway in ovarian granulosa cells by modulating the ROS-dependent mTOR-TFEB pathway

Oxidative stress dysfunction has recently been found to be involved in the pathogenesis of premature ovarian insufficiency (POI). Previously, we found that advanced oxidation protein products (AOPPs) in plasma...

**ng-Yu Zhou, Yun-Hui Lai, Jun Zhang, Ying Li, **ao-Min Wu… in Cell Death & Disease (2024)

Article

From the regulatory mechanism of TFEB to its therapeutic implications

Transcription factor EB (TFEB), known as a major transcriptional regulator of the autophagy-lysosomal pathway, regulates target gene expression by binding to coordinated lysosomal expression and regulation (CL...

Huixia Chen, Siqiao Gong, Hongyong Zhang, Yongming Chen… in Cell Death Discovery (2024)

Article

Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling

Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia, and recent epidemiological studies suggested type 2 diabetes mellitus (T2DM) is an independent risk factor for the development of AF...

Zhi-**ng Wei, **ng-**ng Cai, Yu-Dong Fei, Qian Wang… in Cellular and Molecular Life Sciences (2024)

Article

Nupr1-mediated vascular smooth muscle cell phenotype transformation involved in methamphetamine induces pulmonary hypertension

Nuclear protein 1 (Nupr1) is a multifunctional stress-induced protein involved in the regulation of tumorigenesis, apoptosis, and autophagy. However, its role in pulmonary hypertension (PH) after METH exposure...

Jie Zhou, Dan Guo, Zhen-Zhen Xu, Jia-Shun Liao, **ao-Ting Li… in Cell Biology and Toxicology (2024)

Article

HNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy

Impaired fatty acid oxidation (FAO) is a prominent feature of metabolic remodeling observed in pathological myocardial hypertrophy. Hepatocyte nuclear factor 4alpha (HNF4α) is closely associated with FAO in bo...

Yuxing Hou, Pengxi Shi, Haiyang Du, Chenghao Zhu, Chao Tang… in Cell Death & Disease (2024)