29,226 Result(s)
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**ang-Li Li
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Article
Lnc PVT1 facilitates TGF-β1-induced human cardiac fibroblast activation in vitro and ISO-induced myocardial fibrosis in vivo through regulating MYC
Cardiac fibrosis is a commonly seen pathophysiological process in various cardiovascular disorders, such as coronary heart disorder, hypertension, and cardiomyopathy. Cardiac fibroblast trans-differentiation i...
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Open AccessDevelopment and validation of a risk prediction model for motoric cognitive risk syndrome in older adults
The objective of this study was to develop a risk prediction model for motoric cognitive risk syndrome (MCR) in older adults.
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Coaxial electrospinning of Au@silicate/poly(vinyl alcohol) core/shell composite nanofibers with non-covalently immobilized gold nanoparticles for preparing flexible, freestanding, and highly sensitive SERS substrates amenable to large-scale fabrication
As substrates for surface-enhanced Raman spectroscopy (SERS), novel core/shell composite nanofiber films were prepared by coaxial electrospinning. The shell comprised Au@silicate nanohybrids, i.e., Au nanopart...
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Open AccessThe influence of sex-specific factors on biological transformations and health outcomes in aging processes
The aging process demonstrates notable differences between males and females, which are key factors in disease susceptibility and lifespan. The differences in sex chromosomes are fundamental to the presence of...
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Article
Structure Engineering of Layered Double Hydroxides (LDHs) for Heterogeneous Catalysis
Layered double hydroxide (LDH) is regarded as an advanced platform material in catalysis and attracts vast attrition recently. As a kind of two-dimensional layered material, it exhibits great advantages includ...
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Open AccessPharmacological activity and clinical application analysis of traditional Chinese medicine ginger from the perspective of one source and multiple substances
All types of ginger have common fundamental components, although they possess distinct strengths and inclinations when it comes to effectiveness and medicinal applications. Fresh ginger possesses the ability t...
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Article
A local rainfall-triggered giant landslide occurred in a region along a high-speed railway on the Qinghai–Tibetan Plateau
An increasing number of geological hazards along high-speed railways on the Qinghai–Tibetan Plateau have occurred and have resulted in a profound influence on old infrastructure, which has attracted increasing...
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Article
Open AccessHeritability of functional gradients in the human subcortico-cortical connectivity
The human subcortex plays a pivotal role in cognition and is widely implicated in the pathophysiology of many psychiatric disorders. However, the heritability of functional gradients based on subcortico-cortic...
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Article
Open AccessNeutrophil-derived migrasomes are an essential part of the coagulation system
Migrasomes are organelles that are generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We found that a large number of neutrophil-derived migrasomes exist...
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Article
Open AccessIncreased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway
Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and treatment. This study explored ONECUT2’s role and the specific mechanism...
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Article
Optimization of transverse electro-optic effect in LiNbO3 and LiTaO3 crystals
We analyze the transverse electro-optic (EO) effect in an arbitrary direction in LiNbO3 (LN) and LiTaO3 (LT) crystals based on the Fresnel index ellipsoid theory. A set of analytical formulas for calculating the ...
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Open AccessEvaluating local plant species for effective fall armyworm management strategies in Taiwan
The emergence of Spodoptera frugiperda (fall armyworm; FAW) in the world has raised concerns regarding its impact on crop production, particularly on corn and sorghum. While chemical control and Bt crops have bee...
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Open AccessThe associations between the Geriatric Nutritional Risk Index and all-cause, cancer-specific, and cardiovascular mortality in the U.S. population: a large-scale pooled survey
Previous studies have reported a close association between the Geriatric Nutritional Risk Index (GNRI) and various conditions. However, the association between the GNRI and mortality remains unclear. To examin...
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Open AccessThe burden of non-alcoholic fatty liver disease among working-age people in the Western Pacific Region, 1990–2019: an age–period–cohort analysis of the Global Burden of Disease study
The growing prevalence of non-alcoholic fatty liver disease (NAFLD) in younger populations, particularly those of working age (15–64 years), has become a public health concern. Being diagnosed at a younger age...
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Article
Rab11b promotes M1-like macrophage polarization by restraining autophagic degradation of NLRP3 in alcohol-associated liver disease
Macrophage polarization is vital to mounting a host defense or repairing tissue in various liver diseases. Excessive activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is related to th...
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Article
Open AccessSynthetic macrolides overcoming MLSBK-resistant pathogens
Conventional macrolide-lincosamide-streptogramin B-ketolide (MLSBK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...
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Article
Open AccessExploring usage pattern variation of free-floating bike-sharing from a night travel perspective
Free-floating bike sharing (FFBS) attracts increasing research focusing on usage patterns, determining factors, and integrated transportation. However, existing researchers tend to overlook the variation in us...
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Article
Genetic and clinical characteristics of acute B-cell lymphoblastic leukemia with MEF2D fusions and report of two novel MEF2D rearrangements
The MEF2D rearrangement is a recurrent chromosomal abnormality detected in approximately 2.4–5.3% of patients with acute B-cell lymphoblastic leukemia (B-ALL). Currently, MEF2D-rearranged B-ALL is not classified ...
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Open AccessSurvival of advanced/recurrent gastrointestinal stromal tumors treated with tyrosine kinase inhibitors in Taiwan: a nationwide registry study
Most gastrointestinal stromal tumors (GISTs) harbor c-KIT or PDGFRA mutations. Administration of tyrosine kinase inhibitors (TKIs) has significantly improved the survival of patients with GISTs. We aimed to evalu...
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Perenniality: the tale of three MADS-box genes
