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170 Result(s)
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Article
Open AccessUncertainty-inspired open set learning for retinal anomaly identification
Failure to recognize samples from the classes unseen during training is a major limitation of artificial intelligence in the real-world implementation for recognition and classification of retinal anomalies. W...
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Open AccessNeuro-inspired optical sensor array for high-accuracy static image recognition and dynamic trace extraction
Neuro-inspired vision systems hold great promise to address the growing demands of mass data processing for edge computing, a distributed framework that brings computation and data storage closer to the source...
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Article
Open AccessOncometabolite D-2-hydroxyglutarate—dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia
Cancer cachexia is characterized by weight loss and skeletal muscle wasting. Based on the up-regulation of catabolism and down-regulation of anabolism, here we showed genetic mutation-mediated metabolic reprog...
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Open AccessCorrection to: Association between the triglyceride-glucose index and the risk of mortality among patients with chronic heart failure: results from a retrospective cohort study in China
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Open AccessSingle-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer
Male breast cancer (MBC) is a rare but aggressive malignancy with cellular and immunological characteristics that remain unclear. Here, we perform transcriptomic analysis for 111,038 single cells from tumor ti...
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Open AccessNon-volatile optoelectronic memory based on a photosensitive dielectric
Recently, the optoelectronic memory is capturing growing attention due to its integrated function of sense and memory as well as multilevel storage ability. Although tens of states have been reported in litera...
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Open AccessDissecting peri-implantation development using cultured human embryos and embryo-like assembloids
Studies of cultured embryos have provided insights into human peri-implantation development. However, detailed knowledge of peri-implantation lineage development as well as underlying mechanisms remains obscur...
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Open AccessGround magnetic survey on Mars from the Zhurong rover
Mars’ magnetic field has been measured at large scale by orbiting spacecraft and at very small scale via Martian meteorites. Here we report on a ground magnetic survey on metre to kilometre scales. The Zhurong...
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Open AccessPhosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells
In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T cells through an ‘inside out’ signalling process whereby structurally diverse phosphoantigen (pAg) molecules are sensed by the intr...
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Open Access6-Year trajectory of fasting plasma glucose (FPG) and mortality risk among individuals with normal FPG at baseline: a prospective cohort study
Higher fasting plasma glucose (FPG) levels were associated with an increased risk of all-cause mortality; however, the associations between long-term FPG trajectory groups and mortality were unclear, especiall...
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Open AccessEarliest ceramic drainage system and the formation of hydro-sociality in monsoonal East Asia
The earliest ceramic drainage system unearthed at the **liangtai site on the Central Plains of China represents an unprecedented social and environmental manipulation as societies faced surging environmental...
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Open AccessDifferences in foot shape when wearing wedge-heeled shoes with elevated forefoot height and heel height
Wedge-heeled shoes, which are formed by elevating both the forefoot and heel, have been popular among young women. However, research on the foot shape in wedge-heeled shoes is lacking. This study aimed to acce...
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Open AccessReconstruction of interactions in the ProtoDUNE-SP detector with Pandora
The Pandora Software Development Kit and algorithm libraries provide pattern-recognition logic essential to the reconstruction of particle interactions in liquid argon time projection chamber detectors. Pandor...
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Open AccessClinical significance of B7-H3 expression in circulating CD4+CD25high T cells, CD14+ monocytes, and plasma for the progression of HIV infection
B7-H3 is an important immune checkpoint molecule that plays a negative role in immune regulation. This study was aimed to explore B7-H3 expression in HIV-infected patients and its clinical significance.
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Open AccessGenome-wide association studies identify OsWRKY53 as a key regulator of salt tolerance in rice
Salinity stress progressively reduces plant growth and productivity, while plant has developed complex signaling pathways to confront salt stress. However, only a few genetic variants have been identified to m...
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Open AccesscircDYRK1A tethers biological behaviors of gastric carcinoma using novel bioinformatics analysis and experimental validations
Gastric cancer has been one of the wide public health burdens with its high morbidity and mortality over several decades. As the unconventional modules among RNA families, circular RNAs present their blazing b...
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Open AccessExploiting synergistic effect of CO/NO gases for soft tissue transplantation using a hydrogel patch
Autologous skin flap transplantation is a common method for repairing complex soft tissue defects caused by cancer, trauma, and congenital malformations. Limited blood supply range and post-transplantation isc...
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Open AccessImpaired glymphatic drainage underlying obstructive sleep apnea is associated with cognitive dysfunction
Obstructive sleep apnea (OSA) is highly prevalent but easily undiagnosed and is an independent risk factor for cognitive impairment. However, it remains unclear how OSA is linked to cognitive impairment. In th...
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Open AccessCACA guidelines for holistic integrative management of rectal cancer
Colorectal cancer is a common malignant tumor worldwide. In China, the ratio of rectal cancer to colon cancer in terms of incidence is close to 1: 1. Low rectal cancer accounts for more than half of all cases ...
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Open AccessA lesion-selective albumin-CTLA4Ig as a safe and effective treatment for collagen-induced arthritis
CTLA4Ig is a dimeric fusion protein of the extracellular domain of cytotoxic T-lymphocyte protein 4 (CTLA4) and an Fc (Ig) fragment of human IgG1 that is approved for treating rheumatoid arthritis. However, CTLA4...