8,975 Result(s)
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**-Peng Li
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Article
Open AccessErythroid-intrinsic activation of TLR8 impairs erythropoiesis in inherited anemia
Inherited non-hemolytic anemia is a group of rare bone marrow disorders characterized by erythroid defects. Although concerted efforts have been made to explore the underlying pathogenetic mechanisms of these ...
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Open AccessZero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering
Mutations in amino acid sequences can provoke changes in protein function. Accurate and unsupervised prediction of mutation effects is critical in biotechnology and biomedicine, but remains a fundamental chall...
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Open AccessA novel LGALS1-depended and immune-associated fatty acid metabolism risk model in acute myeloid leukemia stem cells
Leukemia stem cells (LSCs) are recognized as the root cause of leukemia initiation, relapse, and drug resistance. Lipid species are highly abundant and essential component of human cells, which often changed i...
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Open AccessPhase separation of RNF214 promotes the progression of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and the expression and function of an uncharacterized protein RNF214 in HCC are still unknown. Phase separation has recently been obse...
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Open AccessDeep migration learning-based recognition of diseases and insect pests in Yunnan tea under complex environments
The occurrence, development, and outbreak of tea diseases and pests pose a significant challenge to the quality and yield of tea, necessitating prompt identification and control measures. Given the vast array ...
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Boosting alkaline hydrogen evolution via spontaneous built-in electric field
The electrochemical reaction rate strongly depends on the pH of the solution and the relatively sluggish alkaline hydrogen evolution reaction (HER) process, attributed to alterations in the type of proton dono...
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Mechanical and dam** performances of TPMS lattice metamaterials fabricated by laser powder bed fusion
Lattice metamaterials based on three-period minimum surface (TPMS) are an effective means to achieve lightweight and high-strength materials which are widely used in various fields such as aerospace and ships....
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Open AccessUltrabroadband valley transmission and corner states in valley photonic crystals with dendritic structure
In photonic crystal systems, topologically protected edge states and corner states can be achieved by breaking spatial inversion symmetry, which is expected to be applied to topologically protected lasers, opt...
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Article
Open AccessThe effects of temperament type on infusion extravasation in newborns
Infusion extravasation has an increased incidence in newborns, which can result in various adverse outcomes. This study aimed to investigate the effects of different types of temperament on infusion extravasat...
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Open AccessSystematic comparison of sequencing-based spatial transcriptomic methods
Recent developments of sequencing-based spatial transcriptomics (sST) have catalyzed important advancements by facilitating transcriptome-scale spatial gene expression measurement. Despite this progress, effor...
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Article
The light control resistance switch characteristics and conduction mechanism of BaTiO3/MoS2 structure
In this study, Cu/BaTiO3/MoS2/Cu nanodevices were fabricated through magnetron sputtering at room temperature, and the adjustable resistor switching (RS) functionality of the devices under dark and illuminated co...
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Article
Enhancing Lateral Integrity of a Prestressed Concrete Box-Girder Bridge without Transverse Diaphragms: A Study on Strengthening Methods
This study established a finite element model to assess the impact of various transverse strengthening techniques on the **uzhen River Bridge, a prestressed concrete box-girder bridge. On-site experiments vali...
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Fabricating bio-inspired high impact resistance carbon nanotube network films for multi-protection under an extreme environment
The fabrication of light-weight, highly impact-resistant, and energy-absorbent materials is urgently demanded in many facets of the society from body armor to aerospace engineering, especially under an extreme...
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Open AccessActivation of PPAR-α attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis and mitochondrial injury via upregulating 14-3-3η
This study aimed to explore the effects of peroxisome proliferator-activated receptor α (PPAR-α), a known inhibitor of ferroptosis, in Myocardial ischemia/reperfusion injury (MIRI) and its related mechanisms. ...
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Open AccessHypermethylated TAGMe as a universal-cancer-only methylation marker and its application in diagnosis and recurrence monitoring of urothelial carcinoma
Urothelial carcinoma (UC) is the second most common urological malignancy. Despite numerous molecular markers have been evaluated during the past decades, no urothelial markers for diagnosis and recurrence mon...
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Open AccessContrasting observables related to the \(N^*(1535)\) from the molecular or a genuine structure
In this work we compare the predictions for the scattering length and effective range of the channels $$K^0 \Sigma ^+, K^+ \Sigma ^0, K^+ \Lam...
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Functional additives inhibit crystal growth to achieve low-roughness and high-peel strength of micro-coarsening copper foil
With the global proliferation of 5G technology, advancing electronic interconnection technologies has become critically important. The development of high-quality electrolytic copper foils, essential for effic...
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Well-dispersed Sb particles embedded on N-doped carbon nanofibers toward high-performance Li-ion battery
The alloy-type material Sb is widely used in the anode materials of lithium-ion batteries (LIBs) due to its high theoretical specific capacity. However, its serious volume expansion problem during alloying/dea...
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Uniaxial Compression Testing of Sandstone under Microscope: Damage Characteristics and Failure Mechanisms
A compression module system placed under a microscope was utilized to conduct uniaxial compression testing of sandstone samples. The test system can acquire the image of crack propagation on the specimen surfa...
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Analysis of Root Response Mechanism of Quinoa Seedlings to Waterlogging Stress Based on Metabolome
Quinoa, a dicotyledonous annual herb belonging to the subfamily Amaranthaceae, has remarkable resistance to cold, drought, and barren conditions. However, few studies have reported on quinoa root metabolism un...
