231 Result(s)

Article

Poricoic acid A suppresses renal fibroblast activation and interstitial fibrosis in UUO rats via upregulating Sirt3 and promoting β-catenin K49 deacetylation

Renal interstitial fibrosis is the common pathological process of various chronic kidney diseases to end-stage renal disease. Inhibition of fibroblast activation attenuates renal interstitial fibrosis. Our pre...

Dan-Qian Chen, Lin Chen, Yan Guo, **a-Qing Wu, Ting-Ting Zhao… in Acta Pharmacologica Sinica (2023)

Article

CAR T-Cell therapy for the management of mantle cell lymphoma

Mantle cell lymphoma (MCL) is a subtype of Non-Hodgkin lymphoma (NHL) of mature B-cells characterized by translocation, which is typically due to excess expression of Cyclin D1. Although with the progress in o...

Zoufang Huang, Vivek P. Chavda, Rajashri Bezbaruah, Hemant Dhamne… in Molecular Cancer (2023)

Article

BRF2 is mediated by microRNA-409-3p and promotes invasion and metastasis of HCC through the Wnt/β-catenin pathway

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Its invasiveness and ability to metastasize contributes to an extremely high patient mortality. However, the molecular mechanisms tha...

Jian-Hua Chang, Bo-Wen Xu, Di Shen, Wei Zhao, Yue Wang… in Cancer Cell International (2023)

Article

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising ...

Nick Shrine, Abril G. Izquierdo, **g Chen, Richard Packer… in Nature Genetics (2023)

Article

p85S6K sustains synaptic GluA1 to ameliorate cognitive deficits in Alzheimer’s disease

Ribosomal protein S6 kinase 1 (S6K1) is a serine–threonine kinase that has two main isoforms: p70S6K (70-kDa isoform) and p85S6K (85-kDa isoform). p70S6K, with its upstream mammalian target of rapamycin (mTOR)...

Jia-Bing Li, **ao-Yu Hu, Mu-Wen Chen, Cai-Hong **ong… in Translational Neurodegeneration (2023)

Article

Paxlovid accelerates cartilage degeneration and senescence through activating endoplasmic reticulum stress and interfering redox homeostasis

The COVID-19 pandemic has become a huge threat to human health, infecting millions of people worldwide and causing enormous economic losses. Many novel small molecule drugs have been developed to treat patient...

Keyu Kong, Yongyun Chang, Hua Qiao, Chen Zhao… in Journal of Translational Medicine (2022)

Article

A potent, broadly protective vaccine against SARS-CoV-2 variants of concern

Since the first outbreak in December 2019, SARS-CoV-2 has been constantly evolving and five variants have been classified as Variant of Concern (VOC) by the World Health Organization (WHO). These VOCs were fou...

Ziyan Wang, Jiao An, Kunpeng Liu, Pin Yu, **n Fang, Jiadai Li, Hua Zhu… in npj Vaccines (2022)

Article

Tumour inhibitory activity on pancreatic cancer by bispecific nanobody targeting PD-L1 and CXCR4

Antibodies and derivative drugs targeting immune checkpoints have been approved for the treatment of several malignancies, but there are fewer responses in patients with pancreatic cancer. Here, we designed a ...

Shuai Hao, Shuyi Xu, Liangzhu Li, Yaxian Li, Meiqi Zhao, Junsheng Chen… in BMC Cancer (2022)

Article

MIR99AHG inhibits EMT in pulmonary fibrosis via the miR-136-5p/USP4/ACE2 axis

Long non-coding RNAs (lncRNAs) are closely related to the occurrence and development of cancer. Abnormally expressed lncRNA can be used as a diagnostic marker for cancer. In this study, we aim to investigate t...

Jun Wang, Yuan **ang, Sheng-** Yang, Hui-Min Zhang… in Journal of Translational Medicine (2022)

Article

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a m...

Zhe Wang, Andrew Emmerich, Nicolas J. Pillon, Tim Moore, Daiane Hemerich… in Nature Genetics (2022)

Article

A two-stage genome-wide association study to identify novel genetic loci associated with acute radiotherapy toxicity in nasopharyngeal carcinoma

Genetic variants associated with acute side effects of radiotherapy in nasopharyngeal carcinoma (NPC) remain largely unknown.

Yang Wang, Fan **ao, Yi Zhao, Chen-Xue Mao, Lu-Lu Yu, Lei-Yun Wang… in Molecular Cancer (2022)

Article

NFAT inhibitor 11R-VIVIT ameliorates mouse renal fibrosis after ischemia-reperfusion-induced acute kidney injury

Acute kidney injury (AKI) with maladaptive tubular repair leads to renal fibrosis and progresses to chronic kidney disease (CKD). At present, there is no curative drug to interrupt AKI-to-CKD progression. The ...

Zhi-yong **e, Wei Dong, Li Zhang, Meng-jie Wang… in Acta Pharmacologica Sinica (2022)

Article

Non-clinical immunogenicity, biodistribution and toxicology evaluation of a chimpanzee adenovirus-based COVID-19 vaccine in rat and rhesus macaque

Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 has rapidly expanded into a serious global pandemic. Due to the high morbidity and mor...

Xuedong Dai, Weijun Zhao, **n Tong, Wei Liu, **anhuan Zeng… in Archives of Toxicology (2022)

Article

Integrated analysis of single-cell and bulk RNA sequencing data reveals a pan-cancer stemness signature predicting immunotherapy response

Although immune checkpoint inhibitor (ICI) is regarded as a breakthrough in cancer therapy, only a limited fraction of patients benefit from it. Cancer stemness can be the potential culprit in ICI resistance, ...

Zhen Zhang, Zi-**an Wang, Yan-**ng Chen, Hao-**ang Wu, Ling Yin, Qi Zhao… in Genome Medicine (2022)

Article

Correction to: Role of HMGB1 in TNF-α Combined with Z-VAD-fmk-Induced L929 Cells Necroptosis

Zhao Lei, Can Yu, **a Li, Li-Hua Huang, Zhi-Qiang Li, Hong-Wei Zhu… in Biochemical Genetics (2022)

Article

Combined angiogenesis and PD-1 inhibition for immunomodulatory TNBC: concept exploration and biomarker analysis in the FUTURE-C-Plus trial

Immune checkpoint inhibitors had a great effect in triple-negative breast cancer (TNBC); however, they benefited only a subset of patients, underscoring the need to co-target alternative pathways and select op...

Song-Yang Wu, Ying Xu, Li Chen, Lei Fan, **ao-Yan Ma, Shen Zhao… in Molecular Cancer (2022)

Article

Lack of tumorigenesis and protumorigenic activity of human umbilical cord mesenchymal stem cells in NOD SCID mice

The tumorigenesis of infused umbilical cord mesenchymal stem cells (UC-MSCs) is being preclinically evaluated.

Jie He, **ang Yao, ** Mo, Kai Wang, Zai-ling Yang, Ni-ni Tian… in BMC Cancer (2022)

Article

Thrombospondin-2 holds prognostic value and is associated with metastasis and the mismatch repair process in gastric cancer

This study aims to investigate thrombospondin 2 (TSP2) expression levels in gastric cancer (GC) and determine the relationship between TSP2 and clinical characteristics and prognosis.

**ao-dong Chu, Zheng-bin Lin, Ting Huang, Hui Ding, Yi-ran Zhang, Zhan Zhao… in BMC Cancer (2022)

Article

BCL-2 expression promotes immunosuppression in chronic lymphocytic leukemia by enhancing regulatory T cell differentiation and cytotoxic T cell exhaustion

Chronic lymphocytic leukemia (CLL) results in increased susceptibility to infections. T cell dysfunction is not associated with CLL in all patients; therefore, it is important to identify CLL patients with T c...

Lu Liu, **anfeng Cheng, Hui Yang, Senlin Lian, Yuegen Jiang… in Molecular Cancer (2022)

Article

A novel H129-based anterograde monosynaptic tracer exhibits features of strong labeling intensity, high tracing efficiency, and reduced retrograde labeling

Viral tracers are important tools for map** brain connectomes. The feature of predominant anterograde transneuronal transmission offers herpes simplex virus-1 (HSV-1) strain H129 (HSV1-H129) as a promising c...

Hong Yang, Feng **ong, Hai-Bin Qin, Qun-Tao Yu, **-Yan Sun… in Molecular Neurodegeneration (2022)