82 Result(s)
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English
Biomedicine, general
Pharmacology/Toxicology
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Biomedicine
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Article
β-Sitosterol sensitizes MDA-MB-231 cells to TRAIL-induced apoptosis
To investigate whether subtoxic concentration of β-sitosterol (SITO) combined with TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in TRAIL-resistant MDA-MB-231 breast cancer cells.
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Effect of TGF-β1 antisense oligodeoxynucleotide on renal function in chronic renal failure rats
The aim of the present study was to investigate the effectiveness of transforming growth factor (TGF)-β1 antisense oligodeoxynucleotides (ODN) in ameliorating deteriorated kidney function in rats with puromyci...
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Article
Effect of sugar positions in ginsenosides and their inhibitory potency on Na+/K+-ATPase activity
To determine whether ginsenosides with various sugar attachments may act as active components responsible for the cardiac therapeutic effects of ginseng and sanqi (the roots of Panax ginseng and Panax notoginseng
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Effect of calmidazolium on [Ca2+]i and viability in human hepatoma cells
The effect of calmidazolium on cytosolic free Ca2+ concentrations ([Ca2+]i) and viability has not been explored in human hepatoma cells. This study examined whether calmidazolium altered [Ca2+]i and caused cell d...
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Article
Antioxidative and anti-carcinogenic activities of tea polyphenols
Tea (Camellia sinensis, Theaceace), a popular beverage consumed world-wide, has been studied for its preventive effects against cancer as well as cardiovascular, neurodegenerative, and other diseases. Most of the...
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Article
Open AccessLactational coumestrol exposure increases ovarian apoptosis in adult rats
This study is the first to examine the increased apoptosis in the adult rat ovary after lactational exposure to coumestrol (COU), a potent phytoestrogen. Lactating dams were gavaged at doses of 0.01, 0.1, 1, a...
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Article
Increase in sphingolipid catabolic enzyme activity during aging
To understand the contribution of sphingolipid metabolism and its metabolites to development and aging.
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Article
High dosage of Exendin-4 increased early insulin secretion in differentiated beta cells from mouse embryonic stem cells
To investigate early insulin release (EIR) and late insulin release (LIR) upon glucose challenge as well as important insulin signaling factors in differentiated insulin-producing cells from embryonic stem cel...
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Article
Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+-ATPase
To examine if steroid-like compounds found in many Chinese medicinal products conventionally used for the promotion of blood circulation may act as active components via the same molecular mechanism triggered ...
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Article
Magnesium lithospermate B extracted from Salvia miltiorrhiza elevats intracellular Ca2+ level in SH-SY5Y cells
To examine if magnesium lithospermate B (MLB), a potent inhibitor of Na+/K+-ATPase, leads to the elevation of intracellular Ca2+ level as observed in cells treated with cardiac glycosides.
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Article
Potential roles of fibroblast growth factor-9 in the benzo(a)pyrene-induced invasion in vitro and the metastasis of human lung adenocarcinoma
Fibroblast growth factor (FGF)-9 belongs to the FGF family which modulate cell proliferation, differentiation, and motility. Benzo(a)pyrene is a polycyclic aromatic hydrocarbon (PAH) and ubiquitous environment...
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Amounts and proportion of administered pyrene dose excreted as urinary 1-hydroxypyrene after dietary exposure to polycyclic aromatic hydrocarbons
Although urinary 1-hydroxypyrene (1-OHP) is the most relevant parameter for assessing exposure to polycyclic aromatic hydrocarbons, the inability to further elucidate the intra- and inter-individual variabilit...
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Article
Cannabidiol attenuates delayed-type hypersensitivity reactions via suppressing T-cell and macrophage reactivity
To investigate the effects cannabidiol (CBD) on delayed-type hypersensitivity (DTH) reactions and antigen-induced T-cell cytokine expression.
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Article
Upregulation of NF-E2-related factor-2-dependent glutathione by carnosol provokes a cytoprotective response and enhances cell survival
To explore whether glutathione (GSH) increased through Nrf-2 activation is involved in the cytoprotective effects of carnosol in HepG2 cells.
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Article
Advances in the assessment and control of the effector functions of therapeutic antibodies
The Fc (crystallizable fragment) region of therapeutic antibodies can have an important role in their safety and efficacy. This article summarizes the current knowledge of antibody Fc functionality, provides a...
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Article
Active ingredients in Chinese medicines promoting blood circulation as Na+/K+-ATPase inhibitors
The positive inotropic effect of cardiac glycosides lies in their reversible inhibition on the membrane-bound Na+/K+-ATPase in human myocardium. Steroid-like compounds containing a core structure similar to cardi...
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Article
Ethanol-induced small heat shock protein genes in the differentiation of mouse embryonic neural stem cells
Neural stem cells (NSCs) of the neuroepithelium differentiate into one of three central nervous system (CNS) cell lineages: neurons, astrocytes, or oligodendrocytes. In this study, the differentiation potentia...
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Article
Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics
CYP2C9 enzyme metabolizes numerous clinically important drugs. The aim of this study is to investigate the frequencies of CYP2C9 genotypes and the effects of selected alleles on losartan pharmacokinetics in a lar...
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Article
Effect of diindolylmethane on Ca2+ movement and viability in HA59T human hepatoma cells
The effect of diindolylmethane, a natural compound derived from indole-3-carbinol in cruciferous vegetables, on cytosolic Ca2+ concentrations ([Ca2+]i) and viability in HA59T human hepatoma cells is unclear. This...
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Article
Excretion kinetics of urinary 3-hydroxybenzo[a]pyrene following dietary exposure to benzo[a]pyrene in humans
Urinary 3-hydroxy-benzo[a]pyrene (3-OHBaP) is considered as an exposure marker for assessing carcinogenic risks as it is a metabolite of benzo[a]pyrene (BaP). A controlled human study was conducted to examine ...
