40 Result(s)
-
Article
Open AccessLncRNA Airn maintains LSEC differentiation to alleviate liver fibrosis via the KLF2-eNOS-sGC pathway
Long noncoding RNAs (lncRNAs) have emerged as important regulators in a variety of human diseases. The dysregulation of liver sinusoidal endothelial cell (LSEC) phenotype is a critical early event in the fibro...
-
Article
Open AccessCharacteristics of acute kidney injury and its impact on outcome in patients with acute-on-chronic liver failure
Acute kidney injury (AKI) is a common and life-threatening complication of liver failure. The purpose of this study is to construct a nomogram and online calculator to predict the development of hospital-acqui...
-
Article
Open AccessHLF regulates ferroptosis, development and chemoresistance of triple-negative breast cancer by activating tumor cell-macrophage crosstalk
Tumor-associated macrophages (TAMs) are major components of the tumor microenvironment (TME) which are closely associated with the tumor malignant progression. However, the regulatory mechanisms by which TAMs ...
-
Article
Open AccessHepatitis B-related acute-on-chronic liver failure induced by hepatotropic viral insult is associated with worse prognosis than that induced by non-virus insult
The manifestations and prognoses of acute-on-chronic liver failure (ACLF) with different precipitating events remain heterogeneous. We aimed to investigate the characteristics and prognosis of patients with he...
-
Article
Open AccessInvasive Pulmonary Aspergillosis in Acute-on-Chronic Liver Failure Patients: Short-Term Outcomes and Antifungal Options
Acute-on-chronic liver failure (ACLF) patients are susceptible to invasive fungal infections. We evaluated the prognosis and antifungal options in ACLF patients with invasive pulmonary aspergillosis (IPA).
-
Article
Open AccessTolvaptan therapy of Chinese cirrhotic patients with ascites after insufficient diuretic routine medication responses: a phase III clinical trial
To determine the safety and efficacy of different doses of tolvaptan for treating Chinese cirrhotic patients with or without hyponatraemia who still had ascites after routine therapy with diuretics.
-
Article
Evaluation of Adenoid Hypertrophy with Ultrasonography
To determine the reliability of ultrasound in the diagnosis of adenoid hypertrophy in children.
-
Article
Open AccessOptimized real-time fluorescence PCR assay for the detection of porcine Circovirus type 3 (PCV3)
Porcine circovirus type 3 (PCV3) has been an emerging porcine virus spread around the world. The conserved DNA sequence of PCV3 enabled good performance in molecular biological assays.
-
Article
Open AccessAnalysis of the pharmacological mechanism of Banxia **exin decoction in treating depression and ulcerative colitis based on a biological network module
The network pharmacology method was used to predict the active components of Banxia **exin decoction, its targets and the key signalling pathways that are activated in the treatment of depression and ulcerativ...
-
Article
Open AccessLong non-coding RNA THOR promotes ovarian Cancer cells progression via IL-6/STAT3 pathway
Ovarian cancer (OC) is one of the most common malignant tumors in the world. The prognosis of OC remains poor due to the advanced stage and distant metastasis at the time of diagnosis. Recently, a novel lncRNA...
-
Article
Open AccessLiver cirrhosis in a patient with hepatic hereditary hemorrhagic telangiectasia and Budd–Chiari syndrome: a case report
Hereditary hemorrhagic telangiectasia (HHT) often involves the liver, and belongs to abnormal blood vessel disease. The etiology of Budd–Chiari syndrome (BCS) is not clear, but congenital vascular dysplasia is...
-
Article
Open AccessmiR-552 promotes ovarian cancer progression by regulating PTEN pathway
Increasing researches have demonstrated the critical functions of MicroRNAs (miRNAs) in the progression of malignant tumors, including ovarian cancer. It was reported that miR-552 was an important oncogene in ...
-
Article
Open AccessA nationwide survey on neonatal medical resources in mainland China: current status and future challenges
With the rapid development of economy in recent two decades, neonatology has been progressing quickly in China. However, there is little knowledge about the exact developmental status of neonatal departments i...
-
Article
Complications constitute a major risk factor for mortality in hepatitis B virus-related acute-on-chronic liver failure patients: a multi-national study from the Asia–Pacific region
Cirrhosis is a controversial determinant of mortality in HBV-related acute-on-chronic liver failure (HBV–ACLF). The present study aimed to explore the effects of cirrhosis and the associated risk factors, espe...
-
Article
Letter to the Editor concerning “Is MIS-TLIF superior to open TLIF in obese patients?: A systematic review and meta-analysis” by Tan JH et al. (Eur Spine J; 2018: doi:10.1007/s00586-018-5630-0)
-
Article
Histologic transformation of non-small-cell lung cancer in brain metastases
Treatment strategies differ substantially for small-cell lung cancer (SCLC), adenocarcinoma and squamous-cell cancer (SCC). Therefore, it is of important significance to identify histologic transformation. The...
-
Article
Open AccessFive microRNAs in serum as potential biomarkers for prostate cancer risk assessment and therapeutic intervention
Prostate cancer (PCa) is a common malignant human tumor and one of the main causes of cancer-related deaths in men. At present, prostate-specific antigen levels are widely used to diagnose PCa in the clinic, b...
-
Article
Open AccessTolvaptan treatment improves survival of cirrhotic patients with ascites and hyponatremia
Although tolvaptan treatment improves hyponatremia, only few studies have investigated whether tolvaptan actually benefits the survival of cirrhotic patients. This study evaluated the impact of tolvaptan on si...
-
Article
MiR-345 suppresses proliferation, migration and invasion by targeting Smad1 in human prostate cancer
The roles of dysregulated microRNAs in prostate cancer metastasis are still unknown. In this study, we found that the expression of miR-345 was significantly downregulated in prostate cancer and clinical prost...
-
Article
Transsphenoidal pseudocapsule-based extracapsular resection for pituitary adenomas
In the past several years, increasing attention has been paid to the utility of a pseudocapsule in transphenoidal surgery for pituitary adenomas. However, prior studies focused more on the histological structu...
