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Article
Treatment of organophosphate poisoning in pigs: antidote administration by a new binary autoinjector
The therapeutic effectiveness of a new binary autoinjector containing 500 mg HI-6 and 2 mg atropine sulphate was tested in anesthetized pigs poisoned by a lethal dose of soman i.v. (9 μg/kg per 20 min). Pharma...
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Article
Anti-cancer drug characterisation using a human cell line panel representing defined types of drug resistance
Differential drug response in a human cell line panel representing defined types of cytotoxic drug resistance was measured using the non-clonogenic fluorometric microculture cytotoxicity assay (FMCA). In total...
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Article
A New fluorometric assay for determination of osteoblastic proliferation: Effects of glucocorticoids and insulin-like growth factor-I
A novel fluorometric proliferation assay, Ala-marBlue (AB), was used to study the proliferative capacity of isolated human osteoblasts (hOBs). AB is an oxidation-reduction indicator that yields a fluorescent s...
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Article
Cytotoxic activity of cyclosporin A and [3-keto-Bmt1]-[Val2]-cyclosporin (SDZ PSC 833) on tumour cells from patients with haematological malignancies
Objective and method: The fluorometric microculture cytotoxic assay was employed for characterisation of the cytotoxic effect of cyclosporin A (CsA) and its non-immunosuppressive analogu...
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Article
Cytotoxic activity of topotecan in human tumour cell lines and primary cultures of human tumour cells from patients
The cytotoxic activity and cross-resistance pattern of the novel topoisomerase I inhibitor topotecan (Topo) were investigated in ten cell lines, representing different mechanisms of cytotoxic drug resistance, ...
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Article
On the isokinetic effect for reactions of carbon dioxide with metal surfaces
Kinetics data for the reaction CO2(g)→ CO(g)+O(ads) at metal surfaces are used to illustrate a previously developed model for the isokinetic effect. From this, it is concluded that the bending mode of an adsorbed...
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Article
Comparison of the cytotoxic activity of melphalan with L-prolyl-m-L-sarcolysyl-L-p-fluorophenylalanine in human tumour cell lines and primary cultures of tumour cells from patients
m-L-sarcolysin (m-L-SL) is an isomer of melphalan (Mel) with the di(2-chloroethyl) amino group being substituted in the meta position of phenylalanine. By covalent conjugation of amino acids to m-L-SL, a pepti...
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Article
Synergistic interactions of combinations of topotecan with standard drugs in primary cultures of human tumor cells from patients
Objective: Combination therapies are important in the treatment of many tumor types. This study was undertaken to find candidates for combination therapy with the novel topoisomerase I i...
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Article
Topoisomerase II-mediated alterations of K562 drug resistant sublines
In order to further elucidate the, roles of DNA topoisomerase II (topo II) subtypes, α and β, as drug targets in chemotherapy, we have determined the enzyme levels in K562 cells selected for resistance to mito...
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Article
Computational strategy for capturing localization in undrained soil
The paper concerns the issue of progressive development of shear bands in drained and undrained porous media. The main focus is on the design of an overall numerical algorithm to solve the coupled set of non-...
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Article
Cellular cytotoxic drug sensitivity in children with acute leukemia and Down's syndrome: an explanation to differences in clinical outcome?
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Article
Small, novel proteins from the mistletoe Phoradendron tomentosum exhibit highly selective cytotoxicity to human breast cancer cells
Four novel proteins (phoratoxins C–F) have been isolated from the North American mistletoe Phoradendron tomentosum. The amino acid sequences of these phoratoxins were determined unambiguously using a combination...
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Article
Translocation t(1;19) is related to low cellular drug resistance in childhood acute lymphoblastic leukaemia
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Article
Open AccessIdentification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles
Acquired drug resistance is a major problem in cancer treatment. To explore the genes involved in chemosensitivity and resistance, 10 human tumour cell lines, including parental cells and resistant subtypes se...
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Article
Dic(9;20)(p13;q11) in childhood acute lymphoblastic leukaemia is related to low cellular resistance to asparaginase, cytarabine and corticosteroids
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Article
Map** of quick clay formations using geotechnical and geophysical methods
Quick clay has been involved in most serious, large clay slides in Sweden, Norway, and Canada. This paper describes geotechnical and geophysical methods that can be used to locate and map the extent of quick c...
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Article
The Influence of DLC Coating on EHL Friction Coefficient
High hardness, high elastic modulus, low friction characteristics, high wear and corrosion resistance, chemical inertness, and thermal stability are factors that make diamond-like carbon (DLC) coatings the sub...
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Article
Open AccessThe novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia
Aberrantly expressed tyrosine kinases have emerged as promising targets for drug development in acute myeloid leukemia (AML). We report that AKN-028, a novel tyrosine kinase inhibitor (TKI), is a potent FMS-li...
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Article
3-Axis magnetic control: flight results of the TANGO satellite in the PRISMA mission
PRISMA implements guidance, navigation and control strategies for advanced formation flying and rendezvous experiments. The project is funded by the Swedish National Space Board and run by OHB-Sweden in close ...
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Article
Friction Reduction in Elastohydrodynamic Contacts by Thin-Layer Thermal Insulation
Reducing friction is of utmost importance to improve efficiency and lifetime of many products used in our daily lives. Thin hard coatings like diamond-like carbon (DLC) have been shown to reduce friction in fu...
